Blar i NTNU Open på forfatter "Åm, Marte Kierulf"
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Effect of sensor location on continuous intraperitoneal glucose sensing in an animal model
Åm, Marte Kierulf; Kölle, Konstanze; Fougner, Anders Lyngvi; Dirnena-Fusini, Ilze; Bösch, Patrick Christian; Ellingsen, Reinold; Hjelme, Dag Roar; Stavdahl, Øyvind; Carlsen, Sven Magnus; Christiansen, Sverre (Journal article; Peer reviewed, 2018)In diabetes research, the development of the artificial pancreas has been a major topic since continuous glucose monitoring became available in the early 2000’s. A prerequisite for an artificial pancreas is fast and reliable ... -
Intraperitoneal and subcutaneous glucagon delivery in anaesthetized pigs: effects on circulating glucagon and glucose levels
Åm, Marte Kierulf; Dirnena-Fusini, Ilze; Fougner, Anders Lyngvi; Carlsen, Sven Magnus; Christiansen, Sverre (Journal article; Peer reviewed, 2020)Glucagon is a pancreatic hormone and increases the blood glucose levels. It may be incorporated in a dual hormone artificial pancreas, a device to automatically and continuously control blood glucose levels of individuals ... -
The intraperitoneal artificial pancreas: glucose sensing and glucagon delivery
Åm, Marte Kierulf (Doctoral theses at NTNU;2020:267, Doctoral thesis, 2020)Norsk sammendrag Diabetes er en gruppe sykdommer som globalt rammer millioner av mennesker. Denne avhandlingen fokuserer på diabetes mellitus type 1 som kjennetegnes av ingen, eller veldig liten, produksjon av insulin. ... -
Intraperitoneal insulin administration in pigs: Effect on circulating insulin and glucose levels
Dirnena-Fusini, Ilze; Åm, Marte Kierulf; Fougner, Anders Lyngvi; Carlsen, Sven Magnus; Christiansen, Sverre Christian (Peer reviewed; Journal article, 2021)Introduction The effect of intraperitoneal insulin infusion has limited evidence in the literature. Therefore, the aim of the study was to investigate the pharmacokinetics and pharmacodynamics of different intraperitoneal ... -
Intraperitoneal, subcutaneous and intravenous glucagon delivery and subsequent glucose response in rats: A randomized controlled crossover trial
Dirnena-Fusini, Ilze; Åm, Marte Kierulf; Fougner, Anders Lyngvi; Carlsen, Sven Magnus; Christiansen, Sverre (Journal article; Peer reviewed, 2018)Objective Hypoglycemia is a frequent and potentially dangerous event among patients with diabetes mellitus type 1. Subcutaneous glucagon is an emergency treatment to counteract severe hypoglycemia. The effect of intraperitoneal ... -
Pharmacokinetics of Intraperitoneally Delivered Glucagon in Pigs: A Hypothesis of First Pass Metabolism
Teigen, Ingrid Anna; Åm, Marte Kierulf; Carlsen, Sven Magnus; Christiansen, Sverre Christian (Peer reviewed; Journal article, 2021)Background and Objective Artificial pancreases administering low-dose glucagon in addition to insulin have the scope to improve glucose control in patients with diabetes mellitus type 1. If such a device were to deliver ... -
Physiological effects of intraperitoneal versus subcutaneous insulin infusion in patients with diabetes mellitus type 1: A systematic review and meta-analysis
Dirnena-Fusini, Ilze; Åm, Marte Kierulf; Fougner, Anders Lyngvi; Carlsen, Sven Magnus; Christiansen, Sverre Christian (Peer reviewed; Journal article, 2021)The intraperitoneal route of administration accounts for less than 1% of insulin treatment regimes in patients with diabetes mellitus type 1 (DM1). Despite being used for decades, a systematic review of various physiological ... -
Why intraperitoneal glucose sensing is sometimes surprisingly rapid and sometimes slow: A hypothesis
Åm, Marte Kierulf; Fougner, Anders Lyngvi; Ellingsen, Reinold; Hjelme, Dag Roar; Bösch, Patrick Christian; Stavdahl, Øyvind; Carlsen, Sven Magnus; Christiansen, Sverre (Journal article; Peer reviewed, 2019)The artificial pancreas requires fast and reliable glucose measurements. The peritoneal space has shown promising results, and in one of our studies we detected glucose changes in the peritoneal space already at the same ...