Browsing NTNU Open by Author "d'Adda di Fagagna, Fabrizio"

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    • A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres 

      Mentegari, Elisa; Bertoletti, Federica; Kissova, Miroslava; Zucca, Elisa; Galli, Silvia; Tagliavini, Giulia; Garbelli, Anna; Maffia, Antonio; Bione, Silvia; Ferrari, Elena; d'Adda di Fagagna, Fabrizio; Francia, Sofia; Sabbioneda, Simone; Chen, Liuh-Yow; Lingner, Joachim; Bergoglio, Valerie; Hoffmann, Jean-Sebastien; Hübscher, Ulrich; Crespan, Emmanuele; Maga, Giovanni (Peer reviewed; Journal article, 2021)
      Telomerase negative cancer cell types use the Alternative Lengthening of Telomeres (ALT) pathway to elongate telomeres ends. Here, we show that silencing human DNA polymerase (Pol λ) in ALT cells represses ALT activity and ...