Browsing NTNU Open by Author "Vårum, Kjell Morten"
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Alginate gels cross-linked with mixtures of calcium and chitosan oligomers: Effect on swelling properties and leakage from the gel
Myrnes, Erlend Eikeland (Master thesis, 2016)A new alginate gelling system was recently reported where chitosan oligomers were used to cross-link alginate (poly-M) (Khong et al., 2013). These results have been followed up by determining the gel strength and syneresis ... -
Alginate gels with a combination of calcium and chitosan oligomer mixtures as crosslinkers
Feng, Yiming; Kopplin, Georg; Sato, Kimihiko; Draget, Kurt Ingar; Vårum, Kjell Morten (Journal article, 2017)Alginates are polysaccharides that are widely used in relation to their ability to form gels. Recently we reported that alginates may also form gels with chitosan oligomers as crosslinkers (Khong, Aarstad, Skjåk-Bræk, ... -
Chitosan-based nanoparticles for siRNA-mediated downregulation of P-glycoprotein in rat brain endothelial cells in vitro
Auganes, Hanne (Master thesis, 2011)Chitosans are cationic polymers desirable for use in nucleic acid delivery due to its biocompability, biodegradable and low toxic nature. The P-glycoprotein (P-gp) pump is a member of membrane transporters in brain endothelial ... -
Chitosan-based siRNA delivery to rat brain endothelial and glioma cells for optimization of P-glycoprotein knockdown in vitro
Wold, Christian Winther (Master thesis, 2012)The purpose of this thesis was to investigate the transfection efficiencies of chitosan- siRNA nanoparticles in the two rat brain-derived cell lines C6 and RBE4. Furthermore, the main goal was to silence P-glycoprotein ... -
Chitosan: Gels and interfacial properties
Nilsen-Nygaard, Julie; Strand, Sabina P.; Vårum, Kjell Morten; Draget, Kurt Ingar; Nordgård, Catherine Taylor (Journal article; Peer reviewed, 2015)Chitosan is a unique biopolymer in the respect that it is abundant, cationic, low-toxic, non-immunogenic and biodegradable. The relative occurrence of the two monomeric building units (N-acetyl-glucosamine and d-glucosamine) ... -
Covalent binding between chitin and protein
Van de Vyver, Elise (Master thesis, 2015)Chitin is one of the most abundant biopolymers on Earth. The polysaccharide is a linear polymer of β 1,4 linked N-acetyl-D-glucosamine residues. As a structural biopolymer, chitin is mainly occurring in animals with an ... -
Human chitotriosidase-catalyzed hydrolysis of chitosan
Eide, Kristine Bistrup; Norberg, Anne Line; Heggset, Ellinor Bævre; Lindbom, Anne Rita; Vårum, Kjell Morten; Eijsink, Vincent; Sørlie, Morten (Journal article; Peer reviewed, 2012)Chitotriosidase (HCHT) is one of two family 18 chitinases produced by humans, the other being acidic mammalian chitinase (AMCase). The enzyme is thought to be part of the human defense mechanism against fungal parasites, ... -
Methods for quantification and extraction of fucoidan, and quantification of the release of total carbohydrate and fucoidan from the brown algae Laminaria hyperborea
Ahmad, Talha Bin Saleem (Master thesis, 2015)Fucoidan is a sulphated heteropolysaccharide with muglicious nature. It has recently gained much attention because of its bioactive properties. The first objective of this research was to evaluate methods for qualitative ... -
Nanoparticle Mediated P-Glycoprotein Silencing for Improved Drug Delivery across the Blood-Brain Barrier: A siRNA-Chitosan Approach
Malmo, Jostein; Sandvig, Axel; Vårum, Kjell Morten; Strand, Sabina P. (Journal article; Peer reviewed, 2013)Background: Neonatal intermittent hyperoxia-hypoxia (IHH) is involved in the pathogenesis of retinopathy of prematurity. Whether similar oxygen fluctuations will create pathological changes in the grey and white matter ... -
Production and characterization of a novel antifungal chitinase identified by functional screening of a suppressive-soil metagenome
Berini, Francesca; Presti, Ilaria; Beltrametti, Fabrizio; Pedroli, Marco; Vårum, Kjell Morten; Pollegioni, Loredano; Sjöling, Sara; Marinelli, Flavia (Journal article; Peer reviewed, 2017)Background Through functional screening of a fosmid library, generated from a phytopathogen-suppressive soil metagenome, the novel antifungal chitinase—named Chi18H8 and belonging to family 18 glycosyl hydrolases—was ...