Blar i NTNU Open på forfatter "Thomas, David W."
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Bi-functional alginate oligosaccharide–polymyxin conjugates for improved treatment of multidrug-resistant gram-negative bacterial infections
Stokniene, Joana; Powell, Lydia C.; Aarstad, Olav Andreas; Aachmann, Finn Lillelund; Rye, Philip D; Hill, Katja E.; Thomas, David W.; Ferguson, Elaine L. (Peer reviewed; Journal article, 2020)The recent emergence of resistance to colistin, an antibiotic of last resort with dose-limiting toxicity, has highlighted the need for alternative approaches to combat infection. This study aimed to generate and characterise ... -
Structure–Activity Relationships of Low Molecular Weight Alginate Oligosaccharide Therapy against Pseudomonas aeruginosa
Pritchard, Manon F.; Powell, Lydia C.; Adams, Jennifer Y. M.; Menzies, Georgina; Khan, Saira; Tøndervik, Anne; Sletta, Håvard; Aarstad, Olav Andreas; Skjåk-Bræk, Gudmund; McKenna, Stephen; Buurma, Niklaas J.; Farnell, Damian J. J.; Rye, Philip D.; Hill, Katja E.; Thomas, David W. (Peer reviewed; Journal article, 2023)Low molecular weight alginate oligosaccharides have been shown to exhibit anti-microbial activity against a range of multi-drug resistant bacteria, including Pseudomonas aeruginosa. Previous studies suggested that the ...