Blar i NTNU Open på forfatter "Stenvik, Jørgen"
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A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling
Nilsen, Nadra; Gregory I., Vladimer; Stenvik, Jørgen; Ørning, Mathias Pontus; Zeid-Kilani, Maria Vanessa; Bugge, Marit; Bergstrøm, Bjarte; Conlon, Joseph; Husebye, Harald; Amy, Hise; Fitzgerald, Katherine A.; Espevik, Terje; Lien, Egil (Journal article; Peer reviewed, 2015)Toll-like receptors (TLRs) are involved in sensing invading microbes by host innate immunity. TLR2 recognizes bacterial lipoproteins/lipopeptides, and lipopolysaccharide activates TLR4. TLR2 and TLR4 signal via the ... -
Exploring the role of TLR8 as a sensor in bacterial infections
Ehrnström, Birgitta (Doctoral theses at NTNU;2019:382, Doctoral thesis, 2019) -
Human Toll-like Receptor 8 (TLR8) Is an Important Sensor of Pyogenic Bacteria, and Is Attenuated by Cell Surface TLR Signaling
Moen, Siv Helen; Ehrnström, Birgitta; Kojen, June Frengen; Yurchenko, Mariya; Beckwith, Kai Sandvold; Afset, Jan Egil; Damås, Jan Kristian; Zhenyi, Hu; Hang, Yin; Espevik, Terje; Stenvik, Jørgen (Journal article; Peer reviewed, 2019)TLR8 is an endosomal sensor of RNA degradation products in human phagocytes, and is involved in the recognition of viral and bacterial pathogens. We previously showed that in human primary monocytes and monocyte derived ... -
Immunomodulatory effects of iron oxide nanoparticles in two human biological model systems
Wolf-Grosse, Susann (Doctoral theses at NTNU;2017:368, Doctoral thesis, 2017) -
Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model
Wolf-Grosse, Susann; Rokstad, Anne Mari; Ali, Syed; Lambris, JD; Mollnes, Tom Eirik; Nilsen, Asbjørn Magne; Stenvik, Jørgen (Journal article; Peer reviewed, 2017)Abstract: Iron oxide nanoparticles (IONPs) are promising nanomaterials for biomedical applications. However, their inflammatory potential has not been fully established. Here, we used a lepirudin anti-coagulated human whole ... -
Iron oxide nanoparticles modulate lipopolysaccharide-induced inflammatory responses in primary human monocytes
Grosse, Susann; Stenvik, Jørgen; Nilsen, Asbjørn Magne (Journal article; Peer reviewed, 2016)Co-stimulation of the immune system to more than one agent concomitantly is very common in real life, and considering the increasing use of engineered nanoparticles and nanomaterials, it is highly relevant to assess the ... -
Modulating acrylic acid content of nanogels for drug delivery & biocompatibility studies
Sharma, Anuvansh; Raghunathan, Karthik; Solhaug, Helene; Antony, Jibin; Stenvik, Jørgen; Asbjørn, Magne; Bandyopadhyay, Sulalit; Einarsrud, Mari-Ann (Peer reviewed; Journal article, 2021)Dual stimuli-responsive nanogels (NGs) have gained popularity in the field of bio medicine due to their versatile nature of applicability. Poly(N-isopropylacrylamide)-co-poly(acrylic acid) (pNIPAm-pAAc)-based NGs provide ... -
Nanomaterials - Toxic or Therapeutic?
Behsen, Alenka Djarmila (Master thesis, 2020)Nanomaterialer (NMer), slik som nedbrytningsprodukter av plast og konstruerte medikament leveringspartikler, både slippes ut i miljøet og administreres til mennesker i økende grad. Dette gjør at man stiller spørsmål ved ... -
Nanoplastics - A Potential Threat To Human Health?
Solhaug, Helene (Master thesis, 2019)Den økende bruken av nanomaterialer i alt fra forbruksprodukter til medisiner har ført til en økende offentlig interesse for hvilke følger eksponeringen kan ha for mennesker og helse. Det å forstå hvilke inflammatoriske ... -
Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells
Weber, Annkatrin; Schwiebs, Anja; Solhaug, Helene; Stenvik, Jørgen; Nilsen, Asbjørn Magne; Wagner, Martin; Relja, Borna; Radeke, Heinfried H. (Peer reviewed; Journal article, 2022)So far, the human health impacts of nano- and microplastics are poorly understood. Thus, we investigated whether nanoplastics exposure induces inflammatory processes in primary human monocytes and monocyte-derived dendritic ... -
Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo
Nilsen, Kaja Elisabeth; Zhang, Boyao; Skjesol, Astrid; Ryan, Liv; Vagle, Hilde; Bøe, Maren Helene; Orning, Pontus; Kim, Hera; Bakke, Siril Skaret; Elamurugan, Kirusika; Mestvedt, Ingvild Bergdal; Stenvik, Jørgen; Husebye, Harald; Lien, Egil; Espevik, Terje; Yurchenko, Mariya (Peer reviewed; Journal article, 2023)Inflammation plays a crucial role in the development and progression of many diseases, and is often caused by dysregulation of signalling from pattern recognition receptors, such as TLRs. Inhibition of key protein–protein ... -
Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14
Skjeflo, Espen Waage; Christiansen, Dorte; Landsem, Anne; Stenvik, Jørgen; Woodruff, T. M.; Espevik, Terje; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2019)Background Sepsis is a dysregulated host response to infection. The aim of this study was to investigate the effects of complement- and CD14 inhibition on phagocytosis of live and dead Gram-negative and Gram-positive ... -
Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Selective Cytokine Production and Promotes Invasiveness
Bugge, Marit; Bergstrøm, Bjarte; Oda Kamilla, Eide; Helene, Solli; Kjønstad, Ingrid F.; Stenvik, Jørgen; Espevik, Terje; Nilsen, Nadra J. (Journal article; Peer reviewed, 2017)Toll-like receptors (TLR)s are innate immune receptors for microbial molecules and also sense damage-associated molecular patterns released from host cells. Double-stranded RNA and the synthetic analog polyinosinic:polycytidylic ... -
TIRAP/Mal Positively Regulates TLR8‐Mediated Signaling via IRF5 in Human Cells
Nilsen, Kaja Elisabeth; Skjesol, Astrid; Kojen, June Frengen; Espevik, Terje; Stenvik, Jørgen; Yurchenko, Mariya (Peer reviewed; Journal article, 2022)Toll-like receptor 8 (TLR8) recognizes single-stranded RNA of viral and bacterial origin as well as mediates the secretion of pro-inflammatory cytokines and type I interferons by human monocytes and macrophages. TLR8, as ... -
TLR2-ligander hemmer S.aureus indusert produksjon av interferon-β, men forsterker fagocytose i en lepirudin-antikoagulert fullblodmodell av inflammasjon
Blix, Kjetil Jordahl (Master thesis, 2013)S.aureus koloniserer 20 % av befolkningen til en hver tid og er en hyppig årsak til hudinfeksjoner. Ved introduksjon til blodbanen kan S.aureus forårsake livstruende invasive infeksjoner i en mottakelig vert. Tradisjonelt ... -
TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram-positive bacteria
Ehrnstrøm, Birgitta; Kojen, June Frengen; Giambelluca, Miriam; Ryan, Liv; Moen, Siv Helen; Hu, Zhenyi; Yin, Hang; Mollnes, Tom Eirik; Damås, Jan Kristian; Espevik, Terje; Stenvik, Jørgen (Journal article; Peer reviewed, 2020)We recently showed that TLR8 is critical for the detection of Gram‐positive bacteria by human monocytes. Here, we hypothesized that TLR8 and complement together regulate antibacterial responses in human blood. Anticoagulated ... -
TLR8 senses Staphylococcus aureus RNA in human primary monocytes and macrophages and induces IFN-β production via a TAK1-IKKβ-IRF5 signaling pathway
Bergstrøm, Bjarte; Aune, Marie Hjelmseth; Awuh, Jane Atesoh; Kojen, June Frengen; Blix, Kjetil Jordahl; Ryan, Liv; Flo, Trude Helen; Mollnes, Tom Eirik; Espevik, Terje; Stenvik, Jørgen (Journal article, 2015) -
Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages
Ehrnstrøm, Birgitta; Beckwith, Kai Sandvold; Yurchenko, Mariya; Moen, Siv Helen; Frengen Kojen, June; Lentini, Germana; Teti, G.; Damås, Jan Kristian; Espevik, Terje; Stenvik, Jørgen (Journal article; Peer reviewed, 2017)TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor ...