Browsing NTNU Open by Author "Rolfsson, Ottar"
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Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer
Karvelsson, Sigurdur; Wang, Qiong; Hilmarsdòttir, Bylgja; Sigurdsson, Arnar; Moestue, Siver Andreas; Mælandsmo, Gunhild Mari; Halldórsson, Skarphédinn; Gudmundsson, Steinn; Rolfsson, Ottar (Journal article; Peer reviewed, 2021) -
EMT-derived alterations in glutamine metabolism sensitize mesenchymal breast cells to mTOR inhibition
Karvelsson, Sigurdur; Sigurdsson, Arnar; Seip, Kotryna; Grinde, Maria Tunset; Wang, Qiong; Johanssson, Freyr; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas; Rolfsson, Ottar; Halldórsson, Skarphédinn (Peer reviewed; Journal article, 2021)Epithelial-to-mesenchymal transition (EMT) is a fundamental developmental process with strong implications in cancer progression. Understanding the metabolic alterations associated with EMT may open new avenues of treatment ... -
Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition
Haldorsson, Skarphedinn; Rohatgi, Neha; Magnusdottir, Manuela; Choudhary, Kumari; Gudjónsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdòttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild; Gudmundsson, Steinn; Rolfsson, Ottar (Journal article; Peer reviewed, 2017)Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes ... -
UDP-glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines
Wang, Qiong; Karvelsson, Sigurdur Trausti; Johannsson, Freyr; Vilhjalmsson, Arnar Ingi; Hagen, Lars; Fonseca, Davi de Miranda; Sharma, Animesh; Slupphaug, Geir; Rolfsson, Ottar (Journal article; Peer reviewed, 2021)Metabolic rewiring is one of the indispensable drivers of epithelial-mesenchymal transition (EMT) involved in breast cancer metastasis. In this study, we explored the metabolic changes during spontaneous EMT in three ...