Blar i NTNU Open på forfatter "Popescu, Narcis Ioan"
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CD14 inhibition improves survival and attenuates thrombo-inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis
Keshari, Ravi Shankar; Silasi, Robert; Popescu, Narcis Ioan; Regmi, Girija; Chaaban, Hala; Lambris, John D.; Lupu, Cristina; Mollnes, Tom Eirik; Lupu, Florea (Peer reviewed; Journal article, 2020)Background During sepsis, gram‐negative bacteria induce robust inflammation primarily via lipopolysacharride (LPS) signaling through TLR4, a process that involves the glycosylphosphatidylinositol (GPI)‐anchored receptor ... -
Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis
Keshari, Ravi Shankar; Silasi, Robert; Popescu, Narcis Ioan; Patel, Maulin Mukeshchandra; Chaaban, Hala; Lupu, Cristina; Coggeshall, K. Mark; Mollnes, Tom Eirik; Demarco, Steven J.; Lupu, Florea (Journal article; Peer reviewed, 2017)Bacterial sepsis triggers robust activation of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that together contribute to organ failure and death. ...