Blar i NTNU Open på forfatter "Mühlenpfordt, Melina"
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Acoustic Cluster Therapy (ACT) induced immune response in the brain and characterization of ACT cluster activation
Olsen, Emma Bøe (Master thesis, 2021)Abstract will be available on 2024-08-01 -
A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery
Lage Fernandez, Jessica; Årbogen, Sara Beate Stjern; Sadeghinia, Mohammadjavad; Haram, Karin Margrete; Snipstad, Sofie; Torp, Sverre Helge; Einen, Caroline; Mühlenpfordt, Melina; Maardalen, Matilde; Vikedal, Krister; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy, mainly due to its resistance to chemotherapy and its complex tumour microenvironment characterised by stromal desmoplasia. There is a need for new ... -
Focused ultrasound and microbubble treatment increases delivery of transferrin receptor-targeting liposomes to the brain
Olsman, Marieke; Sereti, Viktoria; Mühlenpfordt, Melina; Johnsen, Kasper Bendix; Andresen, Thomas Lars; Urquhart, Andrew James; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)The blood-brain barrier (BBB) is a major obstacle to treating several brain disorders. Focused ultrasound (FUS) in combination with intravascular microbubbles increases BBB permeability by opening tight junctions, creating ... -
Real-time intravital multiphoton microscopy to visualize focused ultrasound and microbubble treatments to increase blood-brain barrier permeability
Poon, Charissa; Mühlenpfordt, Melina; Olsman, Marieke; Kotopoulis, Spiros; Davies, Catharina de Lange; Hynynen, Kullervo (Peer reviewed; Journal article, 2022)The blood-brain barrier (BBB) is a key challenge for the successful delivery of drugs to the brain. Ultrasound exposure in the presence of microbubbles has emerged as an effective method to transiently and locally increase ... -
Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation
van Wamel, Annemieke; Mühlenpfordt, Melina; Hansen, Rune; Healey, Andrew; Villanueva, Flordeliza S.; Kotopoulis, Spiros; Davies, Catharina de Lange; Chen, Xucai (Peer reviewed; Journal article, 2022)Acoustic Cluster Therapy (ACT®) is a platform for improving drug delivery and has had promising pre-clinical results. A clinical trial is ongoing. ACT® is based on microclusters of microbubbles–microdroplets that, when ... -
Ultrasound and Microbubbles Increase the Uptake of Platinum in Murine Orthotopic Pancreatic Tumors
Haram, Karin Margrete; Snipstad, Sofie; Berg, Sigrid; Mjønes, Patricia; Rønne, Elin; Lage Fernandez, Jessica; Mühlenpfordt, Melina; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Objective Currently available cytotoxic treatments have limited effect on pancreatic ductal adenocarcinoma (PDAC) because desmoplastic stroma limits drug delivery. Efforts have been made to overcome these barriers by drug ...