• Estimated Kidney Tubular Secretion and Kidney, Cardiovascular, and Mortality Outcomes in CKD: The Systolic Blood Pressure Intervention Trial 

      Ascher, Simon B.; Shlipak, Michael G.; Katz, Ronit; Bullen, Alexander L.; Scherzer, Rebecca; Hallan, Stein; Cheung, Alfred K.; Raphael, Kalani L.; Estrella, Michelle M.; Jotwani, Vasantha K.; Seegmiller, Jesse C.; Ix, Joachim H.; Garimella, Pranav S. (Peer reviewed; Journal article, 2022)
      Rational & Objective Many drugs, metabolites, and toxins are cleared by the kidneys via tubular secretion. Whether novel endogenous measures of tubular secretion provide information about kidney, cardiovascular, and ...
    • Markers of Kidney Tubular Secretion and Risk of Adverse Events in SPRINT Participants with CKD 

      Bullen, Alexander L.; Ascher, Simon B.; Scherzer, Rebecca; Garimella, Pranav S.; Katz, Ronit; Hallan, Stein; Cheung, Alfred K.; Raphael, Kalani L.; Estrella, Michelle M.; Jotwani, Vasantha K.; Malhotra, Rakesh; Seegmiller, Jesse C.; Shlipak, Michael G.; Ix, Joachim H. (Peer reviewed; Journal article, 2022)
      Significance Statement SPRINT demonstrated in individuals with hypertension and high cardiovascular disease (CVD) risk that intensive BP lowering was associated with decreased risk of CVD events and all-cause mortality. ...