• Complement factors B, D, C3bBbP and risk of future venous thromboembolism 

      Skjeflo, Espen Waage; Evensen, Line Holtet; Jensen, Søren Beck; Latysheva, Nadezhda; Michelsen, Annika Elisabet; Ueland, Thor; Brækkan, Sigrid Kufaas; Hindberg, Kristian Dalsbø; Snir, Omri; Mollnes, Tom Eirik; Hansen, John Bjarne (Peer reviewed; Journal article, 2023)
      The complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE). We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured ...
    • Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors 

      Thibord, Florian; Klarin, Derek; Brody, Jennifer A.; Chen, Ming-Huei; Levin, Michael G.; Chasman, Daniel I.; Goode, Ellen L.; Hveem, Kristian; Teder-Laving, Maris; Martinez-Perez, Angel; Aïssi, Dylan; Daian-Bacq, Delphine; Ito, Kaoru; Natarajan, Pradeep; Lutsey, Pamela L.; Nadkarni, Girish N.; de Vries, Paul S.; Cuellar-Partida, Gabriel; Wolford, Brooke N.; Pattee, Jack W.; Kooperberg, Charles; Brækkan, Sigrid Kufaas; Li-Gao, Ruifang; Saut, Noemie; Sept, Corriene; Germain, Marine; Judy, Renae L.; Wiggins, Kerri L.; Ko, Darae; O'Donnell, Christopher J.; Taylor, Kent D.; Giulianini, Franco; De Andrade, Mariza; Nøst, Therese Haugdahl; Boland, Anne; Empana, Jean-Philippe; Koyama, Satoshi; Gilliland, Thomas; Do, Ron; Huffman, Jennifer E.; Wang, Xin; Zhou, Wei; Manuel Soria, Jose; Carlos Souto, Juan; Pankratz, Nathan; Haessler, Jeffery; Hindberg, Kristian Dalsbø; Rosendaal, Frits R; Turman, Constance; Olaso, Robert; Kember, Rachel L.; Bartz, Traci M.; Lynch, Julie A.; Heckbert, Susan R.; Armasu, Sebastian M.; Brumpton, Ben Michael; Smadja, David M.; Jouven, Xavier; Komuro, Issei; Clapham, Katharine R.; Loos, Ruth J F; Willer, Cristen J.; Sabater-Lleal, Maria; Pankow, James S.; Reiner, Alexander P.; Morelli, Vania Maris; Ridker, Paul M.; Vlieg, Astrid van Hylckama; Deleuze, Jean-François; Kraft, Peter; Rader, Daniel J.; Psaty, Bruce M.; Skogholt, Anne Heidi; Emmerich, Joseph; Suchon, Pierre; Rich, Stephen S.; Vy, Ha My T; Tang, Weihong; Jackson, Rebecca D.; Hansen, John Bjarne; Morange, Pierre-Emmanuel; Kabrhel, Christopher; Trégouët, David-Alexandre; Damrauer, Scott M.; Johnson, Andrew D.; Smith, Nicholas L. (Peer reviewed; Journal article, 2022)
      Background: Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 VTE cases ...
    • High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism 

      Damoah, Christabel Esi; Snir, Omri; Hindberg, Kristian Dalsbø; Garred, Peter; Ludviksen, Judith K; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Mollnes, Tom Eirik; Hansen, John Bjarne (Peer reviewed; Journal article, 2022)
      Background: Experimental studies have shown that the complement activating enzyme MASP-2 (mannose-binding lectin associated serine protease 2) exhibits a thrombin-like activity and that inhibition of MASP-2 protects ...
    • High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism 

      Grover, Steven P.; Snir, Omri; Hindberg, Kristian Dalsbø; Englebert, Tatianna M.; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Jensen, Søren Beck; Wolberg, Alisa S.; Mollnes, Tom Eirik; Ueland, Thor; Mackman, Nigel; Hansen, John Bjarne (Peer reviewed; Journal article, 2023)
      Background C1-inhibitor (C1INH) is a broad-acting serine protease inhibitor with anticoagulant activity. The impact of C1INH plasma levels within the normal physiological range on risk of venous thromboembolism (VTE) ...