• Evaluation of polygenic scoring methods in five biobanks shows larger variation between biobanks than methods and finds benefits of ensemble learning 

      Monti, Remo; Eick, Lisa; Hudjashov, Georgi; Läll, Kristi; Kanoni, Stavroula; Wolford, Brooke Nichole; wingfield, benjamin; Pain, Oliver; Wharrie, Sophie; Jermy, Bradley; McMahon, Aoife; Hartonen, Tuomo; Heyne, Henrike; Mars, Nina; Lambert, Samuel; Hveem, Kristian; Inouye, Michael; Van Heel, David A.; Mägi, Reedik; Marttinen, Pekka; Ripatti, Samuli; Ganna, Andrea; Lippert, Christoph (Peer reviewed; Journal article, 2024)
      Methods of estimating polygenic scores (PGSs) from genome-wide association studies are increasingly utilized. However, independent method evaluation is lacking, and method comparisons are often limited. Here, we evaluate ...