Blar i NTNU Open på forfatter "Gederaas, Odrun Arna"
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A Novel Photosensitizer for PET-Imaging and Cancer Treatment —In vitro studies (AY-27 cells)
Dahl, Hildegunn (Master thesis, 2021) -
Amphiphilic Protoporphyrin IX Derivatives as New Photosensitizing Agents for the Improvement of Photodynamic Therapy
Desgranges, Stéphane; Juzenas, Petras; Vasovic, Vlada; Gederaas, Odrun Arna; Lindgren, Mikael; Warloe, Trond; Qian, Peng; Contino-Pepin, Christiane (Peer reviewed; Journal article, 2022)Photodynamic therapy (PDT) is a non-invasive therapeutic modality based on the interaction between a photosensitive molecule called photosensitizer (PS) and visible light irradiation in the presence of oxygen molecule. ... -
Antitumor effects of selected intermediates in synthesis of unsaturated acyl glucoside. In vitro experiments on cancer cell lines.
Gandawski, Daniel (Master thesis, 2019)I forbindelse med et pågående totalsynteseprosjekt ved NTNU ble biologisk evaluering av mellomprodukter og potensielle fettsyresubstituenter som kreftmiddel utført ved MTT-analyse. I tillegg ble syntesen av to nye ... -
Comparison Between 8-Methoxypsoralen and 5-Aminolevulinic Acid in Killing T Cells of Photopheresis Patients Ex Vivo
Holien, Toril; Gederaas, Odrun Arna; Darvekar, Sagar; Christensen, Eidi; Qian, Peng (Journal article; Peer reviewed, 2018)Background and Objective Extracorporeal photopheresis (ECP), an established modality for cutaneous T‐cell lymphoma (CTCL) and graft‐versus‐host disease, involves ex vivo treatment of isolated leukocytes of a patient with ... -
Effect of photodynamic therapy using hexyl aminolevulinate and Amphinex – in vitro and in vivo studies
Shrestha, Chetana (Master thesis, 2011)Photodynamic therapy (PDT) is based on administration of photosensitizers (PS) which preferentially accumulates in tumor cells, followed by exposure of light that excites PS molecules and generation of singlet oxygen or ... -
Effects of hexyl aminolevulinate and Amphinex based photodynamic therapy and photochemical internalization - in vitro studies using rat bladder cancer cells
Manandhar, Rojlina (Master thesis, 2011)Photodynamic therapy (PDT) is a treatment modality which involves application of photosensitizers and their ability to accumulate selectively and damage cancer cells in presence of light. Light induced damage to cancer ... -
Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization
Baglo, Yan; Hagen, Lars; Høgset, Anders; Drabløs, Finn; Otterlei, Marit; Gederaas, Odrun Arna (Journal article; Peer reviewed, 2014)Bleomycin is a cytotoxic chemotherapeutic agent widely used in cancer treatment. However, its efficacy in different cancers is low, possibly due to limited cellular internalization. In this study, a novel approach known ... -
Increased Anticancer Efficacy of Intravesical Mitomycin C Therapy when combined with a PCNA Targeting Peptide
Gederaas, Odrun Arna; Søgaard, Caroline Danielsen; Viset, Trond; Bachke, Siri; Bruheim, Per; Arum, Carl-Jørgen; Otterlei, Marit (Journal article; Peer reviewed, 2014)Non–muscle-invasive bladder cancers (NMIBCs) are tumors confined to the mucosa or the mucosa/submucosa. An important challenge in treatment of NMIBC is both high recurrence and high progression rates. Consequently, more ... -
Influence of Polymer Charge on the Localization and Dark- and Photo-Induced Toxicity of a Potential Type I Photosensitizer in Cancer Cell Models
Lindgren, Mikael; Gederaas, Odrun Arna; Siksjø, Monica; Hansen, Tom Andre; Chen, Lena; Mettra, Bastien; Andraud, Chantal; Monnereau, Cyrille (Peer reviewed; Journal article, 2020)A current trend within photo-dynamic therapy (PDT) is the development of molecular systems targeting hypoxic tumors. Thus, type I PDT sensitizers could here overcome traditional type II molecular systems that rely on the ... -
On the susceptibility and adaptability of beta cells to stressful conditions: effects of nutrient scarcity, hyperoxia and internalization of amylin
Singh, Rinku (Doctoral theses at NTNU;2018:26, Doctoral thesis, 2018) -
Photochemical internalization by cancer cell lines from rat glioma (F98) and bladder (AY27) and its proteome analysis
Mbarak, Saide Abdulla (Master thesis, 2016) -
Photochemical internalization of peptide antigens provides a novel strategy to realize therapeutic cancer vaccination
Haug, Markus; Brede, Gaute; Håkerud, Monika; Nedberg, Anne Grete; Gederaas, Odrun Arna; Flo, Trude Helen; Edwards, Victoria Tudor; Selbo, Pål Kristian; Høgset, Anders; Halaas, Øyvind (Journal article; Peer reviewed, 2018)Effective priming and activation of tumor-specific CD8+ cytotoxic T lymphocytes (CTLs) is crucial for realizing the potential of therapeutic cancer vaccination. This requires cytosolic antigens that feed into the MHC class ... -
Photodynamic Therapy with Novel Glycosylated Chlorin Complexes on Bladder Cancer Cells from Rat (AY-27) and Human (T-24)
Hageberg, Ingvild Uri (Master thesis, 2021)Formålet med dette masterprosjektet var å utforske fotodynamiske, fotofysiske og fotokjemiske egenskaper til noen nye glykosylerte kloriner. Dette prosjektet er en del av et pågående samarbeid mellom Institutt for fysikk, ... -
Photosensitizing Effects of Novel Glycosylated Chlorin Complexes on the AY-27 Cancer Cell Model
Vindstad, Benedikte Emilie (Master thesis, 2020)Målet for dette prosjektet var å finne potensialet til KA20-familien av glykosylerte kloriner som fotosensibiliserende forbindelser i fotodynamisk terapi (PDT) av kreftsykdom. Kreft er en av verdens ledende dødsårsaker. ... -
Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells
Gederaas, Odrun Arna; Sharma, Animesh; Mbarak, Saide; Sporsheim, Bjørnar; Høgset, Anders; Bogoeva, Vanya; Slupphaug, Geir; Hagen, Lars (Peer reviewed; Journal article, 2023)Photochemical internalization (PCI) is a promising new technology for site-specific drug delivery, developed from photodynamic therapy (PDT). In PCI, light-induced activation of a photosensitizer trapped inside endosomes ... -
Red versus blue light illumination in hexyl 5-aminolevulinate photodynamic therapy: the influence of light color and irradiance on the treatment outcome in vitro
Helander, Linda; Krokan, Hans Einar; Johnsson, Anders Carl G.; Gederaas, Odrun Arna; Plaetzer, Kristjan (Journal article; Peer reviewed, 2014)Abstract. Hexyl 5-aminolevulinate (HAL) is a lipophilic derivative of 5-aminolevulinate, a key intermediate in biosynthesis of the photosensitizer protoporphyrin IX (PpIX). The photodynamic efficacy and cell death mode ... -
Synthesis and in vitro evaluation of a novel thienopyrimidine with phototoxicity towards rat glioma F98 cells
Gederaas, Odrun Arna; Sørensen, Andreas S.; Lindgren, Mikael; Melø, Thor Bernt; Altin, Dag; Flatby, Ellen M. Samdahl; Høgset, Anders; Hoff, Bård Helge (Peer reviewed; Journal article, 2022)Glioblastoma multiforme is one of the most aggressive cancer forms in humans, and has low recovery rates after surgery, ionizing radiation and chemotherapy. Therefore, there is a high interest in the development of new ... -
Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthotopic rat bladder cancer model: possible pathways of action
Arum, Carl-Jørgen; Gederaas, Odrun Arna; Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Hjelde, Astrid; Krokan, Hans Einar; Svaasand, Lars O.; Chen, Duan; Zhao, Chun-Mei (Journal article; Peer reviewed, 2011)Orthotopic bladder cancer model in rats mimics human bladder cancer with respect to urothelial tumorigenesis and progression. Utilizing this model at pT1 (superficial stage), we analyze the tissue responses to hexyl ... -
"Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling
Søgaard, Caroline Krogh; Blindheim, Augun; Røst, Lisa Marie; Petrovic, Voin; Nepal, Anala; Bachke, Siri; Liabakk, Nina-Beate; Gederaas, Odrun Arna; Viset, Trond; Arum, Carl-Jørgen; Bruheim, Per; Otterlei, Marit (Journal article; Peer reviewed, 2018)Low response rate and rapid development of resistance against commonly used chemotherapeutic regimes demand new multi-targeting anti-cancer strategies. In this study, we target the stress-related roles of the scaffold ...