Blar i NTNU Open på forfatter "Bjørnstad, Frithjof Andreas"
-
Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates
Singleton, Amanda Holstad; Bergum, Olaug Elisabeth Torheim; Søgaard, Caroline Krogh; Røst, Lisa M.; Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Ræder, Synnøve Brandt; Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge; Bruheim, Per; Otterlei, Marit (Peer reviewed; Journal article, 2023)The past few decades have been plagued by an increasing number of infections caused by antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new antibiotics with novel targets and drug ... -
Directed Lithiation of Protected 4-Chloropyrrolopyrimidine: Addition to Aldehydes and Ketones Aided by Bis(2-dimethylaminoethyl)ether
Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2023)Pyrrolopyrimidines are important scaffolds for the preparation of bioactive molecules. Therefore, developing efficient and flexible ways for selective functionalization of the pyrrolopyrimidine skeleton is of interest. We ... -
Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland
Bjørnstad, Frithjof Andreas; Havik, Simen; Aarhus, Thomas Ihle; Mahdi, Iktedar; Unger, Anke; Habenberger, Peter; Degenhart, Carsten; Eickhoff, Jan; Klebl, Bert M.; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2024)The colony-stimulating factor 1 receptor (CSF1R) is an attractive target for inflammation disorders and cancers. Based on a series of pyrrolo[2,3-d]pyrimidine containing two carbo-aromatic rings, we have searched for new ... -
Regioselective Protection and Functionalization of C-6 in The Synthesis Towards Sulfoquinovoses
Bjørnstad, Frithjof Andreas (Master thesis, 2018)The main goal of this thesis was to explore and compare two protection strategies yielding 2,3,4-tri-O-benzyl-α-D-glucopyranosides. Further work was done to functionalize the primary 6- hydroxyl position to a sulfonic acid ... -
Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form
Aarhus, Thomas Ihle; Bjørnstad, Frithjof Andreas; Wolowczyk, Camilla Izabel; Larsen, Kristin Uhlving; Rognstad, Line; Leithaug, Trygve; Unger, Anke; Habenberger, Peter; Wolf, Alexander; Bjørkøy, Geir; Pridans, Clare; Eickhoff, Jan; Klebl, Bert; Hoff, Bård Helge; Sundby, Eirik (Peer reviewed; Journal article, 2023)Colony-stimulating factor-1 receptor (CSF1R) is a receptor tyrosine kinase that controls the differentiation and maintenance of most tissue-resident macrophages, and the inhibition of CSF1R has been suggested as a possible ... -
Synthetic Strategies Towards 4,6-Disubstituted Pyrrolopyrimidines and Evaluation of their Potential as Colony Stimulating Factor 1 Receptor Kinase Inhibitors
Bjørnstad, Frithjof Andreas (Doctoral theses at NTNU;2024:60, Doctoral thesis, 2024)Due to their central role in regulating vital cellular processes, protein kinases are increasingly attractive targets in modern drug development. Small molecule drugs have become valuable tools for selectively modulating ...