Browsing NTNU Open by Author "Bjørnland, Thea"
Now showing items 1-13 of 13
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A study of regression models for count data, with applications to salmon lice data
Mæland, Ingrid Langevei (Master thesis, 2023)Den norske lakseoppdrettsindustrien står overfor en betydelig utfordring med forekomst av lakselus (Leopeohtheirus salmonis). Lakselusen skader b˚ade villaks og oppdrettslaks ved å redusere vekstraten deres og til slutt ... -
An Introduction to Copula Theory
Aasen, Nora Røhnebæk (Bachelor thesis, 2021)Målet med denne oppgaven er å gi en kortfattet introduksjon til en gruppe funksjoner kalt copulaer. En betydelig del av oppgaven er avsatt til å forstå og bevise Sklars teorem. Resten av oppgaven presenterer andre grunnleggende ... -
Assessing gene-environment interaction effects of FTO, MC4R and lifestyle factors on obesity using an extreme phenotype sampling design: Results from the HUNT study
Bjørnland, Thea; Langaas, Mette; Mostad, Ingrid Løvold; Grill, Valdemar Erik Robert (Journal article; Peer reviewed, 2017)Background Our aim was to assess the influence of age, gender and lifestyle factors on the effect of the obesity-promoting alleles of FTO and MCR4. Methods The HUNT study comprises health information on the ... -
Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
Gilly, Arthur; Suveges, Daniel; Kuchenbaecker, Karoline; Pollard, Martin; Southam, Lorraine; Hatzikotoulas, Konstantinos; Farmaki, Aliki-Eleni; Bjørnland, Thea; Waples, Ryan; Appel, Emil; Casalone, Elisabetta; Melloni, Giorgio; Kilian, Britt; Rayner, William; Ntalla, Ioanna; Kundu, Kousik; Walter, Klaudia; Danesh, John; Butterworth, Adam; Barroso, Ines; Tsafantakis, Emmanouil; Dedoussis, George; Moltke, Ida; Zeggini, Eleftheria (Journal article; Peer reviewed, 2018)The role of rare variants in complex traits remains uncharted. Here, we conduct deep whole genome sequencing of 1457 individuals from an isolated population, and test for rare variant burdens across six cardiometabolic ... -
Confirmatory factor analysis of the Achievement Goal Questionnaire
Skaue, Nikolai (Bachelor thesis, 2020)Først ser vi på statistisk teori som forklarer hvordan Confimartory factor analyse(CFA) fungerer. Hva som ligger bak CFA, og hvordan man kan bruke CFA til å sammenligne ulike modeller. Deretter vil vi bruke CFA på "Achivement ... -
Digital Learning Resources, Hybrid Teaching And Remote Students - Are Our Students Actively Engaged?
Bjørnland, Thea (Chapter, 2023)At the Norwegian University of Science and Technology, a new cross-campus statistics course for approximately 1000 engineering students was planned for the fall of 2020. Due to the pandemic, digital learning resources were ... -
On response-dependent sampling and score tests for regression models with missing covarities; Applications to extreme phenotype sampling in genetic association studies.
Bjørnland, Thea (Doctoral theses at NTNU;2019:189, Doctoral thesis, 2019) -
Powerful extreme phenotype sampling designs and score tests for genetic association studies
Bjørnland, Thea; Bye, Anja; Ryeng, Einar; Wisløff, Ulrik; Langaas, Mette (Journal article; Peer reviewed, 2018)We consider cross‐sectional genetic association studies (common and rare variants) where non‐genetic information is available or feasible to obtain for N individuals, but where it is infeasible to genotype all N individuals. ... -
Saddlepoint approximated methods for computing p-values in score tests
Aasen, Nora Røhnebæk (Master thesis, 2023)I denne oppgaven presenteres, både teoretisk og ved hjelp av eksempler, to alternative metoder for å regne p-verdier i en score test i motsetning til å anta en normalfordeling på score-statistikken. Vi presenterer en dobbel ... -
Saddlepoint approximations to score test statistics in logistic regression for analyzing genome-wide association studies
Johnsen, Pål Vegard; Bakke, Øyvind; Bjørnland, Thea; DeWan, Andrew Thomas; Langaas, Mette (Peer reviewed; Journal article, 2023)We investigate saddlepoint approximations of tail probabilities of the score test statistic in logistic regression for genome-wide association studies. The inaccuracy in the normal approximation of the score test statistic ... -
Statistical Methods for Genetic Association Studies under the Extreme Phenotype Sampling Design: Modelling the Effects of both Common and Rare Genetic Variants
Bjørnland, Thea (Master thesis, 2014)In this thesis we investigate a concept in genetic association studies known as extreme phenotype sampling (EPS), where phenotype refers to physical appearances and in humans. In EPS studies, only individuals with extreme ... -
Stochastic modelling and analysis of neutral tumor evolution. - Can neutral tumor evolution be inferred from real data?
Johnsen, Pål Vegard (Master thesis, 2018)We develop a branching process with accumulating mutations to model neutral tumor evolution. Furthermore, by using this model, it will be shown in details which approximations and simplifications that are necessary in order ... -
Whole-genome sequencing analysis of the cardiometabolic proteome
Gilly, Arthur; Park, Young-Chen; Png, Grace; Barysenka, Andrei; Fischer, Iris; Bjørnland, Thea; Southam, Lorraine; Suveges, Daniel; Neumeyer, Sonja; Rayner, William; Tsafantakis, Emmanouil; Karaleftheri, Maria; Dedoussis, George; Zeggini, Eleftheria (Journal article; Peer reviewed, 2020)The human proteome is a crucial intermediate between complex diseases and their genetic and environmental components, and an important source of drug development targets and biomarkers. Here, we comprehensively assess the ...