Blar i NTNU Open på forfatter "Damås, Jan Kristian"
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SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
Hammer, Quirin; Dunst, Josefine; Christ, Wanda; Picarazzi, Francesca; Wendorff, Mareike; Momayyezi, Pouria; Huhn, Oisín; Netskar, Herman Krogstad; Maleki, Kimia T.; García, Marina; Sekine, Takuya; Sohlberg, Ebba; Azzimato, Valerio; Aouadi, Myriam; Holten, Aleksander Rygh; Kildal, Anders Benjamin; Lind, Andreas; Dyrhol-Riise, Anne Ma; Hoff, Dag Arne Lihaug; Solligård, Erik; Holter, Jan Cato; Afset, Jan Egil; Damås, Jan Kristian; Hov, Johannes Espolin Roksund; Bergan, Jonas; Risnes, Kari; Muller, Karl Erik; Tonby, Kristian; Heggelund, Lars; Gustad, Lise Tuset; Grimsrud, Marit Mæhle; Vadla, May Sissel; Lenning, Ole Bernt; Myhre, Ronny; Haider, Sammra; Dudman, Susanne Gjeruldsen; Karlsen, Tom Hemming; Folseraas, Trine; Skogen, Vegard; Degenhardt, Frauke; Franke, Andre; Spallotta, Francesco; Mori, Mattia; Michaëlsson, Jakob; Björkström, Niklas K.; Rückert, Timo; Romagnani, Chiara; Horowitz, Amir; Klingström, Jonas; Ljunggren, Hans-Gustaf; Malmberg, Karl-Johan (Peer reviewed; Journal article, 2022)Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in ... -
Secreted wnt antagonists in scrub typhus
Ueland, Thor; Astrup, Elisabeth; Otterdal, Kari; Lekva, Tove; Janardhanan, Jeshina; Prakash, John A.; Thomas, Kurien; Michelsen, Annika; Aukrust, Pål; Varghese, George M.; Damås, Jan Kristian (Peer reviewed; Journal article, 2021)Background The mechanisms that control local and systemic inflammation in scrub typhus have only been partially elucidated. The wingless (Wnt) signaling pathways are emerging as important regulators of inflammation and ... -
Semiquantitative Real-Time PCR to Distinguish Pneumocystis Pneumonia from Colonization in a Heterogeneous Population of HIV-Negative Immunocompromised Patients
Grønseth, Stine; Rogne, Tormod; Hannula, Raisa; Åsvold, Bjørn Olav; Afset, Jan Egil; Damås, Jan Kristian (Peer reviewed; Journal article, 2021)Pneumocystis jirovecii is a threat to iatrogenically immunosuppressed individuals, a heterogeneous population at rapid growth. We assessed the ability of an in-house semiquantitative real-time PCR assay to discriminate ... -
Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
Meås, Hany Zakaria; Haug, Markus; Beckwith, Marianne Sandvold; Louet, Claire; Ryan, Liv; Hu, Zhenyi; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Yin, Hang; Damås, Jan Kristian; Flo, Trude Helen (Journal article; Peer reviewed, 2020)During HIV infection, cell-to-cell transmission results in endosomal uptake of the virus by target CD4+ T cells and potential exposure of the viral ssRNA genome to endosomal Toll-like receptors (TLRs). TLRs are instrumental ... -
Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction
Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Holven, Kirsten Bjørklund; Aukrust, Pål; Gullestad, Lars; Yndestad, Arne; Halvorsen, Bente (Journal article; Peer reviewed, 2018)Background The IL-6 receptor antagonist tocilizumab has been shown to attenuate the proatherogenic lipoprotein a [Lp(a)] in rheumatoid arthritis. We evaluated if a single dose of tocilizumab reduced Lp(a) in patients with ... -
Serum PCSK9 is modified by interleukin-6 receptor antagonism in patients with hypercholesterolaemia following non-ST-elevation myocardial infarction
Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Aukrust, Pål; Gullestad, Lars; Halvorsen, Bente; Yndestad, Arne (Journal article; Peer reviewed, 2018)Objective It is unclear if activation of inflammatory pathways regulates proprotein convertase subtilisin-kexin type 9 (PCSK9) levels. Approach We evaluated (1) the temporal course of serum PCSK9 during hospitalisation ... -
Soluble Markers of the Toll-Like Receptor 4 Pathway Differentiate between Active and Latent Tuberculosis and Are Associated with Treatment Responses
Feruglio, Siri; Trøseid, Marius; Damås, Jan Kristian; Kvale, Dag; Dyrhol-Riise, Anne Ma (Journal article; Peer reviewed, 2013-07-16)Background Biomarkers to differentiate between active tuberculosis (TB) and latent TB infection (LTBI) and to monitor treatment responses are requested to complement TB diagnostics and control, particularly in patients ... -
Staphylococcus aureus-endokarditt ved St.Olavs hospital 2013-2018: epidemiologi og perifere venekatetres rolle
Djuve, Mari Brekke (Master thesis, 2021)Bakgrunn Staphylococcus aureus-endokarditt er en alvorlig sykdom med høy mortalitet. Perifere venekatetre kan være en inngangsport for denne infeksjonen. På grunn av den høye forekomsten av perifere venekatetre i klinisk ... -
Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study
Rath, Eivind; Palma Medina, Laura M.; Jahagirdar, Sanjeevan; Mosevoll, Knut Anders; Damås, Jan Kristian; Madsen, Martin B.; Svensson, Mattias; Hyldegaard, Ole; Martins dos Santos, Vitor A.P.; Saccenti, Edoardo; Norrby-Teglund, Anna; Skrede, Steinar; Bruun, Trond (Peer reviewed; Journal article, 2023)Objective Early stages with streptococcal necrotizing soft tissue infections (NSTIs) are often difficult to discern from cellulitis. Increased insight into inflammatory responses in streptococcal disease may guide correct ... -
Systemic inflammation persists the first year after mild traumatic brain injury: Results from the Prospective Trondheim Mild Traumatic Brain Injury Study
Chaban, Viktoriia; Clarke, Gerard; Skandsen, Toril; Islam, Rakibul; Einarsen, Cathrine Elisabeth; Vik, Anne; Damås, Jan Kristian; Mollnes, Tom Eirik; Håberg, Asta; Pischke, Soeren (Peer reviewed; Journal article, 2020)Innate immune activation has been attributed a key role in traumatic brain injury (TBI) and successive morbidity. In mild TBI (mTBI), however, the extent and persistence of innate immune activation are unknown. We determined ... -
The effects of shift work on the immune system: A narrative review
Thorkildsen, Marianne Stenbekk (Master thesis, 2022)Norsk sammendrag Introduksjon: Skiftarbeid påvirker trolig helsen negativt og en av hypotesene er at skiftarbeid påvirker immunforsvaret og fører til økt risiko for infeksjon. Tidligere litterære sammendrag har konkludert ... -
The impact of infectious disease specialist consultation for Staphylococcus aureus bloodstream infections: A systematic review
Paulsen, Julie; Solligård, Erik; Damås, Jan Kristian; Dewan, Andrew; Åsvold, Bjørn Olav; Bracken, Michael B (Journal article; Peer reviewed, 2016)Staphylococcus aureus is a common cause of severe bloodstream infection.We performed a systematic review to assess whether consultation with infectious disease specialists decreased all-cause mortality or rate of complications ... -
The Palliative Radiotherapy and Inflammation Study (PRAIS) - Protocol for a longitudinal observational multicenter study on patients with cancer induced bone pain 11 Medical and Health Sciences 1103 Clinical Sciences
Habberstad, Ragnhild H; Frøseth, Trude Camilla Salvesen; Aass, Nina Kathrine; Abramova, Tatiana Mikhailovna; Baas, Theo; Mørkeset, Siri Tessem; Caraceni, Augusto; Laird, Barry J; Boland, Jason W.; Rossi, Romina; Garcia-Alonso, Elena; Stensheim, Hanne; Loge, Jon Håvard; Hjermstad, Marianne Jensen; Bjerkeset, Ellen; Bye, Asta; Lund, Jo-Åsmund; Solheim, Tora Skeidsvoll; Vagnildhaug, Ola Magne; Brunelli, Cinzia; Damås, Jan Kristian; Mollnes, Tom Eirik; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2018)Background Radiation therapy (RT) results in pain relief for about 6 of 10 patients with cancer induced bone pain (CIBP) caused by bone metastases. The high number of non-responders, the long median time from RT to pain ... -
TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram-positive bacteria
Ehrnstrøm, Birgitta; Kojen, June Frengen; Giambelluca, Miriam; Ryan, Liv; Moen, Siv Helen; Hu, Zhenyi; Yin, Hang; Mollnes, Tom Eirik; Damås, Jan Kristian; Espevik, Terje; Stenvik, Jørgen (Journal article; Peer reviewed, 2020)We recently showed that TLR8 is critical for the detection of Gram‐positive bacteria by human monocytes. Here, we hypothesized that TLR8 and complement together regulate antibacterial responses in human blood. Anticoagulated ... -
Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction
Helseth, Ragnhild; Kleveland, Ola; Ueland, Thor; Wiseth, Rune; Damås, Jan Kristian; Broch, Kaspar; Michelsen, Annika Elisabet; Bendz, Bjørn; Gullestad, Lars; Aukrust, Pål; Seljeflot, Ingebjørg (Peer reviewed; Journal article, 2021)Objective Beyond reducing inflammation and troponin T (TnT) release, the interleukin-6 receptor antagonist tocilizumab reduces neutrophil counts in patients with non-ST segment elevation myocardial infarction (NSTEMI). It ... -
Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages
Ehrnstrøm, Birgitta; Beckwith, Kai Sandvold; Yurchenko, Mariya; Moen, Siv Helen; Frengen Kojen, June; Lentini, Germana; Teti, G.; Damås, Jan Kristian; Espevik, Terje; Stenvik, Jørgen (Journal article; Peer reviewed, 2017)TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor ... -
Transitions Between Circulatory States After Out-of-Hospital Cardiac Arrest: Protocol for an Observational, Prospective Cohort Study
Langeland, Halvor; Bergum, Daniel; Løberg, Magnus; Bjørnstad, Knut; Damås, Jan Kristian; Mollnes, Tom Eirik; Skjaervold, Nils Kristian; Klepstad, Pål (Journal article; Peer reviewed, 2018)Background: The post cardiac arrest syndrome (PCAS) is responsible for the majority of in-hospital deaths following cardiac arrest (CA). The major elements of PCAS are anoxic brain injury and circulatory failure. Objective: ... -
Trends in antimicrobial resistance and empiric antibiotic therapy of bloodstream infections at a general hospital in Mid-Norway: A prospective observational study
Mehl, Arne; Åsvold, Bjørn Olav; Kümmel, Angela; Lydersen, Stian; Paulsen, Julie; Haugan, Ingvild; Solligård, Erik; Damås, Jan Kristian; Harthug, Stig; Edna, Tom-Harald (Journal article; Peer reviewed, 2017)Background The occurrence of bloodstream infection (BSI) and antimicrobial resistance have been increasing in many countries. We studied trends in antimicrobial resistance and empiric antibiotic therapy at a medium-sized ... -
Trends in mortality after a sepsis hospitalization: a nationwide prospective registry study from 2008 to 2021
Skei, Nina Vibeche; Nilsen, Tom Ivar Lund; Mohus, Randi Marie; Prescott, Hallie C.; Lydersen, Stian; Solligård, Erik; Damås, Jan Kristian; Gustad, Lise Tuset (Peer reviewed; Journal article, 2023)Background Few studies have reported on mortality beyond one year after sepsis. We aim to describe trends in short- and long-term mortality among patients admitted with sepsis, and to describe the association between ... -
Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels
Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen; Damås, Jan Kristian; Østvik, Ann Elisabet; Bruland, Torunn; Sandvik, Arne Kristian (Peer reviewed; Journal article, 2019)Neutrophil gelatinase‐associated lipocalin (NGAL), also known as Lipocalin 2, is an antimicrobial protein, encoded by the gene LCN2, strongly upregulated in inflammatory bowel disease (IBD) and a promising biomarker for ...