Blar i NTNU Open på forfatter "Aachmann, Finn Lillelund"
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Production and Biochemical Characterization of Laminaria hyperborea Fucoidan Modifying Enzymes
Storrø, Tina (Master thesis, 2022)Norges lange og varierte kystlinje er et blomstrende habitat for brune makroalger. Disse brune makroalgene har et høyt innhold av karbohydrater, noe som gjør dem til gode råvarer for bio-raffinering. Utnyttelse av brune ... -
Production, characterization, and application of an alginate lyase, AMOR_PL7A, from hot vents in the Arctic mid-ocean ridge
Vuoristo, Kiira; Fredriksen, Lasse; Oftebro, Maren; Arntzen, Magnus Øverlie; Aarstad, Olav Andreas; Stokke, Runar; Steen, Ida Helene; Hansen, Line Degn; Schüller, Reidar Barfod; Aachmann, Finn Lillelund; Horn, Svein Jarle; Eijsink, Vincent (Peer reviewed; Journal article, 2019)Enzymatic depolymerization of seaweed polysaccharides is gaining interest for the production of functional oligosaccharides and fermentable sugars. We describe a thermostable alginate lyase belonging to Polysaccharide Lyase ... -
Protective Face Mask Filter Capable of Inactivating SARS-CoV-2, and Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis
Marti, Miguel; Tunon-Molina, Alberto; Aachmann, Finn Lillelund; Muramoto, Yukiko; Noda, Takeshi; Takayama, Kazuo; Serrano-Aroca, Angel (Peer reviewed; Journal article, 2021)Face masks have globally been accepted to be an effective protective tool to prevent bacterial and viral transmission, especially against indoor aerosol transmission. However, commercial face masks contain filters that are ... -
Recombinant expression and structural investigation of JdLPMO10A using Nuclear magnetic Resonance (NMR) spectroscopy
(Master thesis, 2019)En bærekraftig produksjon av karbonnøytral energi er ekstremt viktig dersom verdenssamfunnet skal oppnå 2,0 graders målet satt ved Parisavtalen i 2015. Et stort fokus har derfor blitt lagt på utviklingen av fornybare ... -
Resonance assignments for the apo-form of the cellulose-active lytic polysaccharide monooxygenase TaLPMO9A
Kitaoku, Yoshihito; Courtade, Gaston; Petrovic, Dejan; Fukamizo, Tamo; Eijsink, Vincent; Aachmann, Finn Lillelund (Journal article; Peer reviewed, 2018)The apo-form of the 24.4 kDa AA9 family lytic polysaccharide monooxygenase TaLPMO9A from Thermoascus aurantiacus has been isotopically labeled and recombinantly expressed in Pichia pastoris. In this paper, we report the ... -
Role of GCN5 and PCAF in the B Lymphocyte Development
Chau, Khac Thanh Phong (Master thesis, 2018)DNA in our cells is constantly damage by internal and external factors generating DSBs. To maintain genome stability, cells have developed various DNA damage surveillance and repair mechanisms to prevent chromosomal ... -
Role of GCN5 and PCAF in the B Lymphocyte Development
Chau, Khac Thanh Phong (Master thesis, 2018)DNA in our cells is constantly damage by internal and external factors generating DSBs. To maintain genome stability, cells have developed various DNA damage surveillance and repair mechanisms to prevent chromosomal ... -
RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork
Kavli, Bodil Merete; Iveland, Tobias Solli; Buchinger, Edith; Hagen, Lars; Liabakk, Nina-Beate; Aas, Per Arne; Obermann, Tobias Sebastian; Aachmann, Finn Lillelund; Slupphaug, Geir (Journal article; Peer reviewed, 2021)Uracil occurs at replication forks via misincorporation of deoxyuridine monophosphate (dUMP) or via deamination of existing cytosines, which occurs 2-3 orders of magnitude faster in ssDNA than in dsDNA and is 100% miscoding. ... -
Simultaneous analysis of C1 and C4 oxidized oligosaccharides, the products of lytic polysaccharide monooxygenases acting on cellulose
Westereng, Bjørge; Arntzen, Magnus Øverlie; Aachmann, Finn Lillelund; Varnai, Aniko; Eijsink, Vincent; Wittrup Agger, Jane (Journal article; Peer reviewed, 2016)Lytic polysaccharide monooxygenases play a pivotal role in enzymatic deconstruction of plant cell wall material due to their ability to catalyze oxidative cleavage of glycosidic bonds. LPMOs may release different products, ... -
Single-Molecule Pair Studies of RGD-Coupled Alginate and Integrin
Lee, Hye Won (Master thesis, 2014) -
Structural and functional aspects of mannuronic acid–specific PL6 alginate lyase from the human gut microbe Bacteroides cellulosilyticus
Stender, E.G.P.; Andersen, C.D.; Fredslund, F.; Holck, J.; Solberg, Amalie; Teze, D.; Peters, G.H.J.; Christensen, Bjørn E.; Aachmann, Finn Lillelund; Welner, D.H.; Svensson, B. (Journal article; Peer reviewed, 2019)Alginate is a linear polysaccharide from brown algae consisting of 1,4-linked β-D-mannuronic acid (M) and α-L-guluronic acid (G) arranged in M, G, and mixed MG blocks. Alginate was assumed to be indigestible in humans, but ... -
Structural and functional characterization of the R-modules in alginate C-5 epimerases AlgE4 and AlgE6 from Azotobacter vinelandii
Buchinger, Edith; Knudsen, Daniel H.; Behrens, Manja A.; Pedersen, Jan Skov; Aarstad, Olav Andreas; Tøndervik, Anne; Valla, Svein; Skjåk-Bræk, Gudmund; Wimmer, Reinhard; Aachmann, Finn Lillelund (Journal article; Peer reviewed, 2014)The bacterium Azotobacter vinelandii produces a family of seven secreted and calcium-dependent mannuronan C-5 epimerases (AlgE1–7). These epimerases are responsible for the epimerization of β-d-mannuronic acid (M) to ... -
Structural and functional variation of chitin-binding domains of a lytic polysaccharide monooxygenase from Cellvibrio japonicus
Madland, Eva; Forsberg, Zarah; Wang, Yong; Lindorff-Larsen, Kresten; Niebisch, Axel; Modregger, Jan; Eijsink, Vincent; Aachmann, Finn Lillelund; Courtade, Gaston (Peer reviewed; Journal article, 2021)Among the extensive repertoire of carbohydrate-active enzymes, lytic polysaccharide monooxygenases (LPMOs) have a key role in recalcitrant biomass degradation. LPMOs are copper-dependent enzymes that catalyze oxidative ... -
SULFATED ALGINATES: Characterization and applications as biomaterials
Arlov, Øystein (Doctoral thesis at NTNU;2016:159, Doctoral thesis, 2016)As natural constituents of the extracellular matrix, sulfated glycosaminoglycans (GAGs) are of great interest in the design of novel biomaterials for cell immobilization and tissue engineering. A substantial challenge ... -
Synthesis of glycoconjugates utilizing the regioselectivity of a lytic polysaccharide monooxygenase
Westereng, Bjørge; Kračun, SK; Leivers, Shaun Allan; Arntzen, Magnus Øverlie; Aachmann, Finn Lillelund; Eijsink, Vincent (Peer reviewed; Journal article, 2020)Polysaccharides from plant biomass are the most abundant renewable chemicals on Earth and can potentially be converted to a wide variety of useful glycoconjugates. Potential applications of glycoconjugates include therapeutics ... -
Terminally modified alginates as universal tool for its bi-functionalization
Brativnyk, Anastasia (Master thesis, 2020)Alginat er en viktig polysakkarid med et bredt bruksåmråde innen industri og forskning på grunn av dets egne egenskaper. Disse egenskapene inkluderer evne til å lage gel, øke viskositet og løse opp et gelnettverk. Det har ... -
The carbohydrate-binding module and linker of a modular lytic polysaccharide monooxygenase promote localized cellulose oxidation
Courtade, Gaston; Forsberg, Zarah; Heggset, Ellinor Bævre; Eijsink, Vincent; Aachmann, Finn Lillelund (Journal article; Peer reviewed, 2018)Lytic polysaccharide monooxygenases (LPMOs) are copper-dependent enzymes that catalyze the oxidative cleavage of polysaccharides such as cellulose and chitin, a feature that makes them key tools in industrial biomass ... -
The edible mushroom Albatrellus ovinus contains a α-L-fuco-α-D-galactan, α-D-glucan, a branched (1→6)-β-D-glucan and a branched (1→3)-β-D-glucan
Samuelsen, Anne Berit C.; Rise, Frode; Wilkins, Alistair L.; Teveleva, Lioubov; Nyman, Anna Armika Tussilago; Aachmann, Finn Lillelund (Journal article; Peer reviewed, 2019)Albatrellus ovinus, the sheep polypore, is a large, dense mushroom being rich in cell wall material. Polysaccharides were isolated by sequential extraction, enzymatic treatment and analyzed with respect to monosaccharide ... -
Unaided efficient transglutaminase cross-linking of whey proteins strongly impacts the formation and structure of protein alginate particles
Madsen, Mikkel; Khan, Sanaullah; Kunstmann, Sonja; Aachmann, Finn Lillelund; Ipsen, Richard; Westh, Peter; Emanuelsson, Cecilia; Svensson, Birte (Peer reviewed; Journal article, 2022)There is a dogma within whey protein modification, which dictates the necessity of pretreatment to enzymatic cross-linking of β-lactoglobulin (β-Lg). Here microbial transglutaminase (MTG) cross-linked whey proteins and ... -
Using carbohydrates to improve a hypothetical process for the enzymatic degradation of PET
Berget, Asle Hammer (Master thesis, 2023)Plast har blitt etablert som utmerkede materialer med mange bruksområder. Mange plasttyper er hardføre, lette, billige og har barriereegenskaper. Den utbredte tilstedeværelsen av plast, sammen med utilstrekkelige ...