Blar i NTNU Open på forfatter "Johansen, Berit"
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LysoPC and PAF Trigger Arachidonic Acid Release by Divergent Signaling Mechanisms in Monocytes
Oestvang, Janne; Anthonsen, Marit Walbye; Johansen, Berit (Journal article; Peer reviewed, 2011)Oxidized low-density lipoproteins (LDLs) play an important role during the development of atherosclerosis characterized by intimal inflammation and macrophage accumulation. A key component of LDL is lysophosphatidylcholine ... -
Mechanisms of cytosolic phospholipase A2 alpha regulated fibrosis in chronic kidney disease
Trøen, Hanne Hein (Master thesis, 2020)Kronisk nyresykdom (CKD) er et globalt folkehelseproblem, og utviklingen av sykdommen er assosiert med vevsinflammasjon som påvirker fibrosedannelse. Fibrose er et vanlig kjennetegn ved CKD. Sykdommen påvirker nyrestruktur ... -
Modulating macrophage phenotypes as a therapeutic strategy in neurodegenerative diseases
Qvale, Emma Martine (Master thesis, 2018)Macrophages are sentinel cells and are responsible for maintaining homeostasis in tissues and balancing the expression of proinflammatory versus anti-inflammatory factors. In the central nervous system (CNS), the balance ... -
Multicolor flowcytometrisk immunfenotyping for B-cellepopulasjoner i blod- og benmargsprøver
Østlie, Ingunn (Master thesis, 2011)Denne oppgaven har hatt som mål å finne egnete multicolor antistoffkombinasjoner for identifisering av B-cellepopulasjoner i blod og benmarg ved hjelp av flowcytometrisk immunfenotyping. B-cellepopulasjoner av interesse ... -
Studies of Insulin and Cytokine Regulation of Fatty Acid Desaturases, FOXO3A and FOXO3A Target Genes in THP-1 Monocytes
Tønnessen, Marianne Lode (Master thesis, 2012)The increase of obesity that we have experienced during the last decades and its association with insulin resistance, type 2 diabetes and other metabolic diseases has resulted in an enormous interest for understanding the ... -
Targeting Cytosolic Phospholipase A2 alpha (cPLA2α) in Hematological Cancers and Inflammation
Mahammad, Nur (Doctoral theses at NTNU;2023:409, Doctoral thesis, 2023)Cytosolic phospholipase A2 alpha (cPLA2α) is an enzyme that plays a crucial role in regulating the balance between cellular growth and death by releasing the unsaturated fatty acid arachidonic acid from membrane lipids. ... -
The Effect of a balanced Diet on Serum IL-6 Concentration in obese Women.
Johnsen, Kristin (Master thesis, 2014)Word Heath Organization (WHO) estimates that 2.8 million adults die each year as a result of obesity. Raised Body Mass Index (BMI) can lead to lifestyle diseases such as Cardio Vascular Diseases (CVD), Type 2 Diabetes (T2D) ... -
The effect of cPLA2 inhibition in basal-like breast cancer
Akan, Madina (Master thesis, 2016)The effect of cPLA2 inhibition in basal-like breast cancer Introduction: Altered metabolism in cells is a hallmark of cancer and cytosolic phospholipase A2 (cPLA2) is a ubiquitous enzyme involved in inflammation. Recent ... -
The Effect of Platelet Lysate as a Medium Supplement in Cultures of Human Multiple Myeloma
Bruvoll, Ingrid Engum (Master thesis, 2014)Multiple myeloma (MM) is a cancer of antibody-producing plasma cells in the bone marrow. It is the second most frequent hematological malignancy and comprises 1 % of all cancer. Most human myeloma cell lines (hMCLs) derived ... -
The ethics of access to patented biotech research tools from universities and other research institutions
Egelie, Knut Jørgen; Johansen, Berit; Strand, Sabina P.; Myskja, Bjørn Kåre (Journal article; Peer reviewed, 2018)As universities and public research organizations increasingly partner with industry to fulfill their 'third mission' of innovation activities for economic and societal benefit, they have ethical obligations to ensure ... -
The Function of Endomucin in Murine Hematopoietic Stem Cells
Drilsvik, Martine (Master thesis, 2022)Hematopoietiske stamceller (HSCs) er ansvarlig for den livslange produksjonen av alle blodceller og defineres av sin kapasitet til å rekonstruere hele blodsystemet til en mottaker etter HSC transplantasjon. På grunn av ... -
The role of bioactive lipids in keratinocyte hyperproliferation
Lunden, Hanne Enakshi (Master thesis, 2023)Hyperprolifering i keratinocytter er et kjennetegn i sykdomsutviklingen i flere hudsykdommer, som psoriasis, aktin keratose, og keratinocyttkarsinom. Mekanismene som driver keratinocytt hyperproliferering kan bli knyttet ... -
The Role of cPLA2α in Squamous Cell Carcinoma
Østerhaug, Eline Wålen (Master thesis, 2023)Skvamøs cellekarcinom (SCC) er en type hudkreft som skyldes abnormale, hyperprolifererende keratinocytter, og den står for flest dødsfall blant ikke-melanoma hudkreft-tilfeller. Hovedrisikofaktoren er kumulativ eksponering ... -
The role of PRL-3 in Multiple Myeloma cells in the context of BCR signaling
Cócera Fernández, Miguel (Master thesis, 2021)Mylomatose, eller Multiple Myloma (MM) er en B-cellet ondartet kreftart som er kjennetegnet av samling og spredning av plastmaceller som utskiller antistoffer igjennom beinmargen. MM er en sykdom med høy genetisk heterogenitet ... -
Utvidet studie av PLA2-uttrykk i HaCaT-keratinocytter: .
Hansen, Kari Ellen (Master thesis, 2011)I denne masteroppgaven har det blitt utviklet primerpar for 17 humane PLA2-isotyper. Ved hjelp av primerene har vi påvist uttrykk av 17 PLA2-isotyper i HaCaT-keratinocytter, hvorav 11 av disse representerer førstegangspåvisninger ... -
Visualization of Nuclear Factor Kappa B (NF-κB) Translocation and Quantitative Processing of Confocal Microscopy Images in Synoviocytes
Rodriguez, Lorena (Master thesis, 2016)Rheumatoid arthritis is a chronic, progressive, inflammatory autoimmune disease that can cause severe joint destruction and disability. There have been major strides in understanding how the inflammatory process leads to ...