Browsing NTNU Open by Author "Yndestad, Arne"
Now showing items 21-26 of 26
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Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction
Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Holven, Kirsten Bjørklund; Aukrust, Pål; Gullestad, Lars; Yndestad, Arne; Halvorsen, Bente (Journal article; Peer reviewed, 2018)Background The IL-6 receptor antagonist tocilizumab has been shown to attenuate the proatherogenic lipoprotein a [Lp(a)] in rheumatoid arthritis. We evaluated if a single dose of tocilizumab reduced Lp(a) in patients with ... -
Serum PCSK9 is modified by interleukin-6 receptor antagonism in patients with hypercholesterolaemia following non-ST-elevation myocardial infarction
Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Aukrust, Pål; Gullestad, Lars; Halvorsen, Bente; Yndestad, Arne (Journal article; Peer reviewed, 2018)Objective It is unclear if activation of inflammatory pathways regulates proprotein convertase subtilisin-kexin type 9 (PCSK9) levels. Approach We evaluated (1) the temporal course of serum PCSK9 during hospitalisation ... -
Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction
Orrem, Hilde Lang; Shetelig, Christian; Ueland, Thor; Limalanathan, Shanmuganathan; Nilsson, Per; Husebye, Trygve Guttorm; Aukrust, Pål; Seljeflot, Ingebjørg; HOFFMANN, PAVEL; Eritsland, Jan; Mollnes, Tom Eirik; Andersen, Geir Øystein; Yndestad, Arne (Journal article; Peer reviewed, 2018)Background The inflammatory response following myocardial infarction (MI) is prerequisite for proper healing of infarcted tissue, but can also have detrimental effects on cardiac function. Interleukin (IL)-1α and IL-1β ... -
The alternative complement pathway is dysregulated in patients with chronic heart failure
Shahini, Negar; Michelsen, Annika; Nilsson, Per; Ekholt, Karin; Gullestad, Lars; Broch, Kaspar; Dahl, Christen Peder; Aukrust, Pål; Ueland, Thor; Mollnes, Tom Eirik; Yndestad, Arne; Louwe, Maria Cornelia (Journal article; Peer reviewed, 2017)The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; ... -
The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis
Hovland, Anders; Jonasson, Lena; Garred, Peter; Yndestad, Arne; Aukrust, Pål; Lappegård, Knut Tore; Espevik, Terje; Mollnes, Tom Eirik (Peer reviewed; Journal article, 2015)Despite recent medical advances, atherosclerosis is a global burden accounting for numerous deaths and hospital admissions. Immune-mediated inflammation is a major component of the atherosclerotic process, but earlier ... -
Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
Abraityte, Judita Aurelija; Lunde, Ida Gjervold; Askevold, Erik Tandberg; Michelsen, Annika; Christensen, Geir Arve; Aukrust, Pål; Yndestad, Arne; Fiane, Arnt E; Andreassen, Arne K.; Aakhus, Svend; Dahl, Christen Peder; Gullestad, Lars; Broch, Kaspar; Ueland, Thor (Journal article; Peer reviewed, 2017)The Wingless (Wnt) pathway has been implicated in the pathogenesis of dilated cardiomyopathy (DCM). To explore the role of Wnt modulators Wnt5a and sFRP3 in DCM patients we analyzed the expression of Wnt5a and sFRP3 in ...