• Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight 

      Iurilli, Maria Laura Caminia; Zhou, Bin; Bennett, James E.; Carrillo-Larco, Rodrigo M.; Sophiea, Marisa K.; Rodriguez-Martinez, Andrea; Bixby, Honor; Solomon, Bethlehem D.; Taddei, Cristina; Danaei, Goodarz; Di Cesare, Mariachiara; Stevens, Gretchen A.; Riley, Leanne M.; Savin, Stefan; Cowan, Melanie J.; Bovet, Pascal; Damasceno, Albertino Antonio Moura; Chirita-Emandi, Adela; Hayes, Alison J; Ikeda, Nayu; Jackson, Rod T.; Khang, Young-Ho; Laxmaiah, Avula; Liu, Jing; Miranda, J. Jaime; Saidi, Olfa; Sebert, Sylvain; Sorić, Maroje; Starc, Gregor; Gregg, Edward W.; Abarca-Gómez, Leandra; Abdeen, Ziad A.; Abdrakhmanova, Shynar; Ghaffar, Suhaila Abdul; Rahim, Hanan Abdul; Abu-Rmeileh, Niveen M.; Garba, Jamila Abubakar; Acosta-Cazares, Benjamin; Adams, Robert J.; Aekplakorn, Wichai; Afsana, Kaosar; Afzal, Shoaib; Agdeppa, Imelda A.; Aghazadeh-Attari, Javad; Aguilar-Salinas, Carlos A.; Agyemang, Charles; Ahmad, Mohamad Hasnan; Ahmad, Noor Ani; Ahmadi, Ali; Ahmadi, Naser; Hassan, Soheir; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ariansen, Inger Kristine Holtermann; Bergh, Ingunn Holden; Bjertness, Espen; Bjertness, Marius Bergsmark; Ekelund, Ulf; Graff-Iversen, Sidsel; Grøholt, Else Karin; Haugsgjerd, Teresa Risan; Janszky, Imre; Kolle, Elin; Krokstad, Steinar; Madar, Ahmed Ali; Mathiesen, Ellisiv B.; Meisfjord, Jørgen Rajan; Meyer, Haakon Eduard; Sen, Abhijit; Skodje, Gry Irene; Sørgjerd, Elin Pettersen; Sparboe-Nilsen, Bente; Steene-Johannessen, Jostein; Tarp, Jakob; Tell, Grethe S.; Torheim, Liv Elin; Wilsgaard, Tom (Peer reviewed; Journal article, 2021)
      From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated ...
    • Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT) 

      Samuelsen, Per-Jostein; Eggen, Anne Elise; Steigen, Terje; Wilsgaard, Tom; Kristensen, Andreas; Skogsholm, Anne; Holme, Elizabeth; van den Heuvel, Christian; Nordrehaug, Jan Erik; Bendz, Bjørn; Nilsen, Dennis W.T.; Bønaa, Kaare Harald (Peer reviewed; Journal article, 2021)
      Introduction Bleeding is a concern after percutaneous coronary intervention (PCI) and subsequent dual antiplatelet therapy (DAPT). We herein report the incidence and risk factors for major bleeding in the Norwegian Coronary ...
    • Lifestyle behavior among lymphoma survivors after high-dose therapy with autologous hematopoietic stem cell transplantation, assessed by patient-reported outcomes 

      Bersvendsen, Hanne Skjerven; Haugnes, Hege Sagstuen; Fagerli, Unn-Merete; Fluge, Øystein; Holte, Harald; Smeland, Knut Bjøro; Wilsgaard, Tom; Kiserud, Cecilie E. (Journal article; Peer reviewed, 2019)
      Introduction: High-dose therapy with autologous stem cell transplantation (HD-ASCT) is associated with an increased risk of late effects. Our aim was to assess lifestyle behavior and factors associated with unhealthy ...
    • Lifestyle factors as mediators of area-level socioeconomic differentials in mental health and cognitive function: the Tromsø Study 

      Tiwari, Sweta; Cerin, Ester; Wilsgaard, Tom; Løvsletten, Ola; Grimsgaard, Anne Sameline; Hopstock, Laila Arnesdatter; Schirmer, Henrik; Rosengren, Annika; Kristoffersen, Kathrine; Løchen, Maja-Lisa (Peer reviewed; Journal article, 2023)
      Introduction Low socioeconomic status (SES) is associated with poor mental health and cognitive function. Individual-level SES and area-level SES (ASES) may affect mental health and cognitive function through lifestyle. ...
    • Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 

      Albrektsen, Grethe; Wilsgaard, Tom; Heuch, Ivar; Løchen, Maja-Lisa; Thelle, Dag Steinar; Njølstad, Inger; Grimsgaard, Sameline; Bønaa, Kaare Harald (Peer reviewed; Journal article, 2023)
      Background The atherosclerotic effect of an adverse lipid profile is assumed to accumulate throughout life, leading to increased risk of myocardial infarction (MI). Still, little is known about age at onset and duration ...
    • Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905–1977 in the population-based Tromsø Study 1979–2016 

      Hopstock, Laila Arnesdatter; Bønaa, Kaare; Eggen, Anne Elise; Grimsgaard, Sameline; Jacobsen, Bjarne K.; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom (Journal article; Peer reviewed, 2017)
      Objectives Elevated blood cholesterol is a modifiable risk factor for cardiovascular disease. Cholesterol level surveillance is necessary to study population disease burden, consider priorities for prevention and intervention ...
    • Metachronous Contralateral Testicular Cancer in the Cisplatin Era: A Population-Based Cohort Study 

      Hellesnes, Ragnhild; Myklebust, Tor Åge; Bremnes, Roy M.; Karlsdottir, Åsa; Kvammen, Øivind; Negaard, Helene Francisca Stigter; Tandstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen (Peer reviewed; Journal article, 2020)
      PURPOSE It is hypothesized that cisplatin-based chemotherapy (CBCT) reduces the occurrence of metachronous contralateral (second) germ cell testicular cancer (TC). However, studies including treatment details are lacking. ...
    • Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance 

      Jacobsen, Henrik Børsting; Stubhaug, Audun; Schirmer, Henrik; Landrø, Nils Inge; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Nielsen, Christopher Sivert (Peer reviewed; Journal article, 2019)
      Background: Effects from cognitive performance on pain tolerance have been documented, however, sample sizes are small and confounders often overlooked. We aimed to establish that performance on neuropsychological tests ...
    • Obesity does not protect from subarachnoid haemorrhage: Pooled analysis of 3 large prospective Nordic cohorts 

      Rautalin, Ilari; Kaprio, Jaakko; Ingebrigtsen, Tor; Jousilahti, Pekka; Løchen, Maja-Lisa; Romundstad, Pål Richard; Salomaa, Veikko; Vik, Anne; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Sandvei, Marie Søfteland; Korja, Miikka (Journal article; Peer reviewed, 2021)
      Background and Purpose: Several population-based cohort studies have related higher body mass index (BMI) to a decreased risk of subarachnoid hemorrhage (SAH). The main objective of our study was to investigate whether ...
    • Occupational physical activity and risk of mortality in women and men: the Tromsø Study 1986–2021 

      Sagelv, Edvard Hamnvik; Dalene, Knut Eirik; Eggen, Anne Elise; Ekelund, Ulf; Fimland, Marius Steiro; Heitmann, Kim Arne; Holtermann, Andreas; Johansen, Kristoffer Robin; Løchen, Maja-Lisa; Morseth, Bente; Wilsgaard, Tom (Peer reviewed; Journal article, 2023)
      Objective Associations between occupational physical activity (OPA) and mortality risks are inconclusive. We aimed to examine associations between (1) OPA separately and (2) jointly with leisure time physical activity ...
    • Patterns of detectable viraemia among children and adults with HIV infection taking antiretroviral therapy in Zimbabwe 

      Sovershaeva, Evgeniya; Shamu, Tinei; Wilsgaard, Tom; Bandason, Tsitsi; Flægstad, Trond; Katzenstein, David; Ferrand, Rashida A.; Odland, Jon Øyvind (Journal article; Peer reviewed, 2018)
      Objective To investigate the incidence and predictors of viraemia among individuals on antiretroviral therapy (ART) in Harare, Zimbabwe. Methods Children (0–19 years) and adults (>19 years) starting ART between 2013 ...
    • Polybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls: Repeated measurements prior to and after diagnosis 

      Charles, Dolley; Berg, Vivian; Nøst, Therese Haugdahl; Wilsgaard, Tom; Bergdahl, Ingvar A.; Huber, Sandra; Ayotte, Pierre; Averina, Maria; Sandanger, Torkjel M; Rylander, Karin Charlotta Maria (Peer reviewed; Journal article, 2023)
      Background Previous studies have reported associations between certain persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM). Polybrominated diphenyl ethers (PBDEs) are a class of POPs that are found ...
    • Repositioning of the global epicentre of non-optimal cholesterol 

      Taddei, Cristina; Zhou, Bin; Bixby, Honor; Carrillo-Larco, Rodrigo M.; Danaei, Goodarz; Jackson, Rod T.; Ahmed, Soheir H; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ariansen, Inger Kristine Holtermann; Bjertness, Espen; Bjertness, Marius Bergsmark; Graff-Iversen, Sidsel; Haugsgjerd, Teresa Risan; Janszky, Imre; Krokstad, Steinar; Laugsand, Lars Erik; Madar, Ahmed Ali; Mathiesen, Ellisiv B.; Meyer, Haakon E; Sen, Abhijit; Tell, Grete S.; Vatten, Lars Johan; Wilsgaard, Tom; Farzadfar, Farshad; Sophiea, Marisa K.; Di Cesare, Mariachiara; Iurilli, Maria L. C.; Martinez, Andrea Rodriguez; Asghari, Golaleh; Dhana, Klodian; Gulayin, Pablo; Kakarmath, Sujay; Santero, Marilina; Voortman, Trudy; Riley, Leanne M.; Cowan, Melanie J.; Savin, Stefan; Bennett, James E.; Stevens, Gretchen A.; Paciorek, Christopher J.; Aekplakorn, Wichai; Cifkova, Renata; Giampaoli, Simona; Kengne, Andre Pascal; Khang, Young-Ho; Kuulasmaa, Kari; Laxmaiah, Avula; Margozzini, Paula; Mathur, Prashant (Peer reviewed; Journal article, 2020)
      High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using ...
    • Rising rural body-mass index is the main driver of the global obesity epidemic in adults 

      Bixby, Honor; Bentham, James; Zhou, Bin; Di Cesare, Mariachiara; Paciorek, Christopher J.; Bennett, James E.; Taddei, Cristina; Stevens, Gretchen A.; Rodriguez-Martinez, Andrea; Carrillo-Larco, Rodrigo M.; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ekelund, Ulf; Kolle, Elin; Steene-Johannessen, Jostein; Tarp, Jakob; Ariansen, Inger; Biehl, Anna Månsson; Graff-Iversen, Sidsel; Meisfjord, Jørgen Rajan; Bjertness, Espen; Bjertness, Marius Bergsmark; Meyer, Haakon E; Haugsgjerd, Teresa Risan; Tell, Grethe S.; Janszky, Imre; Krokstad, Steinar; Laugsand, Lars Erik; Sen, Abhijit; Vatten, Lars Johan; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Khang, Young-Ho; Soric, Maroje; Gregg, Edward W.; Miranda, J. Jaime; Bhutta, Zulfiqar A.; Savin, Stefan; Sophiea, Marisa K.; Iurilli, Maria L. C.; Solomon, Bethlehem D.; Cowan, Melanie J.; Riley, Leanne M.; Danaei, Goodarz; Bovet, Pascal; Chirita-Emandi, Adela; Hambleton, Ian R; Hayes, Alison J; Ikeda, Nayu; Kengne, Andre P; Laxmaiah, Avula (Journal article; Peer reviewed, 2019)
      Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most ...
    • Risk of atrial fibrillation and stroke among older men exposed to prolonged endurance sport practice: a 10-year follow-up. The Birkebeiner Ageing Study and the Tromsø Study 

      Johansen, Kristoffer Robin; Ranhoff, Anette Hylen; Sørensen, Eivind; Nes, Bjarne; Heitmann, Kim Arne; Apelland, Turid; Bucher Sandbakk, Silvana; Wilsgaard, Tom; Løchen, Maja-Lisa; Thelle, Dag Steinar; Morseth, Bente; Myrstad, Marius (Peer reviewed; Journal article, 2022)
      Aims Endurance sport practice is associated with a high prevalence of atrial fibrillation (AF), which increases the risk of stroke in the general population. However, stroke risk in endurance athletes with AF is sparsely ...
    • Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial. 

      Roaldsen, Melinda Berg; Eltoft, Agnethe; Wilsgaard, Tom; Christensen, Hanne; Engelter, Stefan T.; Indredavik, Bent; Jatužis, Dalius; Karelis, Guntis; Kõrv, Janika; Lundström, Erik; Petersson, Jesper; Putaala, Jukka; Søyland, Mary-Helen; Tveiten, Arnstein; Bivard, Andrew; Johnsen, Stein Harald; Mazya, Michael; Werring, David J; Wu, Teddy Y; de Marchis, Gian Marco; Robinson, Thompson G; Mathiesen, Ellisiv B (Peer reviewed; Journal article, 2022)
      Background - Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access ...
    • SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe 

      Achenbach, Stephan; Aleksandrova, Krasimira; Amiano, Pilar; Amouyel, Philippe; Andersson, Jonas; Bakker, Stephan J.L.; Meyer, Haakon Eduard; Selmer, Randi Marie; Braaten, Tonje; Hveem, Kristian; Lyngbakken, Magnus Nakrem; Mathiesen, Ellisiv B.; Omland, Torbjørn; Wilsgaard, Tom; Costa, Rui Bebiano Da Providencia; Beulens, Joline W. J.; Blaha, Michael J.; Bobak, Martin; Boer, Jolanda M.A.; Bonet, Catalina; Bonnet, Fabrice; Boutron-Ruault, Marie-Christine; Brenner, Hermann; Brunner, Fabian; Brunner, Eric J.; Brunström, Mattias; Buring, Julie; Butterworth, Adam S.; Capkova, Nadezda; Cesana, Giancarlo; Chrysohoou, Christina; Colorado-Yohar, Sandra; Cook, Nancy R.; Cooper, Cyrus; Dahm, Christina C.; Davidson, Karina W.; Dennison, Elaine; Castelnuovo, Augusto Di; Donfrancesco, Chiara; Dörr, Marcus; Dorynska, Agnieszka; Eliasson, Mats; Engström, Gunnar; Ferrari, Pietro; Ferrario, Marco; Ford, Ian; Fu, Michael; Gansevoort, Ron T.; Giampaoli, Simona; Gillum, Richard F. (Peer reviewed; Journal article, 2021)
      Aims The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) to estimate 10-year fatal and non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or ...
    • Sexual function in long-term male lymphoma survivors after high-dose therapy with autologous stem-cell transplantation 

      Bersvendsen, Hanne Skjerven; Haugnes, Hege Sagstuen; Dahl, Alv A; Fagerli, Unn-Merete; Fluge, Øystein; Holte, Harald; Seland, Mette; Wilsgaard, Tom; Smeland, Knut Bjøro; Kiserud, Cecilie E. (Journal article; Peer reviewed, 2019)
      Reduced sexual function may have negative implications on health related quality of life among lymphoma survivors. A national cross-sectional study among long-term lymphoma survivors after high-dose therapy with autologous ...
    • Statistical analysis plan for the randomized controlled trial Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST) 

      Eltoft, Agnethe; Wilsgaard, Tom; Roaldsen, Melinda Berg; Søyland, Mary-Helen; Lundström, Erik; Petersson, Jesper; Indredavik, Bent; Putaala, Jukka; Christensen, Hanne; Kõrv, Janika; Jatužis, Dalius; Engelter, Stefan T.; De Marchis, Gian Marco; Werring, David J.; Robinson, Thompson; Tveiten, Arnstein; Mathiesen, Ellisiv B. (Peer reviewed; Journal article, 2022)
      Background Patients with wake-up ischemic stroke are frequently excluded from thrombolytic treatment due to unknown symptom onset time and limited availability of advanced imaging modalities. The Tenecteplase in Wake-up ...
    • Ten-year mortality among older male recreational endurance athletes in the Birkebeiner Aging Study in comparison with older men from the Tromsø Study 

      Johansen, Kristoffer Robin; Hylen Ranhoff, Anette; Sørensen, Eivind; Nes, Bjarne Martens; Sandbakk, Silvana Bucher; Wilsgaard, Tom; Løchen, Maja-Lisa; Thelle, Dag Steinar; Morseth, Bente; Myrstad, Marius (Peer reviewed; Journal article, 2023)
      Background Physical activity (PA) is associated with reduced mortality. However, whether there is an added benefit of long-term endurance training is unclear. Thus, we aimed to examine 10-year mortality in older male ...