Blar i NTNU Open på forfatter "Sulheim, Einar"
-
The effect of poly(ethylene glycol) coating and monomer type on poly(alkyl cyanoacrylate) nanoparticle interactions with lipid monolayers and cells
Baghirov, Habib; Melikishvili, Sopio; Mørch, Yrr Asbjørg; Sulheim, Einar; Åslund, Andreas; Hianik, Tibor; Davies, Ruth Catharina de Lange (Journal article, 2017)The interaction of the promising drug carriers poly(alkyl cyanoacrylate) nanoparticles (PACA NPs) with lipid monolayers modeling the cell membrane and with RBE4 immortalized rat brain endothelial cells was compared to ... -
Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model
Sulheim, Einar; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Borgos, Sven Even F.; Miletic, Hrvoje; Bjerkvig, Rolf; Davies, Catharina de Lange; Åslund, Andreas (Journal article, 2019)Treatment of glioblastoma and other diseases in the brain is especially challenging due to the blood-brain barrier, which effectively protects the brain parenchyma. In this study we show for the first time that cabazitaxel, ... -
Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine
Snipstad, Sofie; Vikedal, Krister; Maardalen, Matilde; Kurbatskaya, Anna; Sulheim, Einar; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)Successful delivery of drugs and nanomedicine to tumors requires a functional vascular network, extravasation across the capillary wall, penetration through the extracellular matrix, and cellular uptake. Nanomedicine has ... -
Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine
Snipstad, Sofie; Vikedal, Krister; Maardalen, Matilde; Kurbatskaya, Anna; Sulheim, Einar; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)Successful delivery of drugs and nanomedicine to tumors requires a functional vascular network, extravasation across the capillary wall, penetration through the extracellular matrix, and cellular uptake. Nanomedicine has ... -
Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts
Snipstad, Sofie; Berg, Sigrid; Mørch, Ýrr Asbjørg; Bjørkøy, Astrid; Sulheim, Einar; Hansen, Rune; Grimstad, Ingeborg; van Wamel, Annemieke; Maaland, Astri Fjelde; Torp, Sverre Helge; Davies, Ruth Catharina de Lange (Journal article; Peer reviewed, 2017)Compared with conventional chemotherapy, encapsulation of drugs in nanoparticles can improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient and heterogeneous because of various ... -
Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model
Baghirov, Habib; Snipstad, Sofie; Sulheim, Einar; Berg, Sigrid; Hansen, Rune; Thorsen, Frits; Mørch, Ýrr Asbjørg; Davies, Catharina de Lange; Åslund, Andreas (Journal article; Peer reviewed, 2018)The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug ... -
Ultrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Model
Fagerland, Stein-Martin Tilrum; Berg, Sigrid; Hill, Deborah Katherine; Snipstad, Sofie; Sulheim, Einar; Hyldbakk, Astrid; Kim, Jana; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)Ultrasound (US) in combination with microbubbles (MB) has had promising results in improving delivery of chemotherapeutic agents. However, most studies are done in immunodeficient mice with xenografted tumors. We used two ...