Blar i NTNU Open på forfatter "Sikorski, Pawel"
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Influence of Nanopillar Arrays on Fibroblast Motility, Adhesion, and Migration Mechanisms
Beckwith, Kai Sandvold; Ullmann, Sindre; Vinje, Jakob; Sikorski, Pawel (Journal article; Peer reviewed, 2019)Surfaces decorated with high aspect ratio nanostructures are a promising tool to study cellular processes and design novel devices to control cellular behavior. However, little is known about the dynamics of cellular ... -
Local structure of Ca2+ alginate hydrogels gelled via competitive ligand exchange and measured by small angle X-ray scattering
Yamamoto, K; Yuguchi, Yoshiaki; Stokke, Bjørn Torger; Sikorski, Pawel; Bassett, David (Journal article; Peer reviewed, 2019)Alginates, being linear anionic co-polymers of 1,4-linked residues β-d-ManA (M) and α-l-GulA (G), are widely applied as hydrogel biomaterials due to their favourable in vivo biocompatibility and convenient ionic crosslinking. ... -
Micro-scale studies of microbialinduced carbonate precipitation for the application of biocementation
Zehner, Jennifer (Doctoral theses at NTNU;2021:59, Doctoral thesis, 2021)Cement, which is used as a binding material in conventional concrete, is the second most consumed material by humans, after water. The production process of cement, however, causes a high emission of CO2 and contributes ... -
Microbial-induced calcium carbonate precipitation: An experimental toolbox for in situ and real-time investigation of micro-scale pH evolution
Zehner, Jennifer Simone; Røyne, Anja; Wentzel, Alexander; Sikorski, Pawel (Peer reviewed; Journal article, 2020)Concrete is the second most consumed product by humans, after water. However, the production of conventional concrete causes more than 5% of anthropogenic CO2 emissions and therefore there is a need for emission-reduced ... -
Nucleation and Growth of Brushite in the Presence of Alginate
Ucar, Seniz; Bjørnøy, Sindre Hove; Bassett, David; Strand, Berit Løkensgard; Sikorski, Pawel; Andreassen, Jens-Petter (Journal article, 2015)Biomineral formation in vivo is a complex process regulated by functional molecules. Highlighting the mechanisms underlying biomineralization is necessary for a better understanding of in vivo processes and for enhanced ... -
Osteocyte-Like Cells Differentiated From Primary Osteoblasts in an Artificial Human Bone Tissue Model
Munir, Arooj; Reseland, Janne Elin; Tiainen, Hanna; Haugen, Håvard Jostein; Sikorski, Pawel; Christiansen, Emil; Reinholt, Finn P.; Syversen, Unni; Solberg, Lene Bergendal (Peer reviewed; Journal article, 2023)In vitro models of primary human osteocytes embedded in natural mineralized matrix without artificial scaffolds are lacking. We have established cell culture conditions that favored the natural 3D orientation of the bone ... -
Osteogenic differentiation of human mesenchymal stem cells in mineralized alginate matrices
Westhrin, Marita; Xie, Minli; Olderøy, Magnus Ø.; Sikorski, Pawel; Strand, Berit Løkensgard; Standal, Therese (Journal article; Peer reviewed, 2015)Mineralized biomaterials are promising for use in bone tissue engineering. Culturing osteogenic cells in such materials will potentially generate biological bone grafts that may even further augment bone healing. Here, ... -
Patterned cell arrays and patterned co-cultures on polydopamine-modified poly(vinyl alcohol) hydrogels
Beckwith, Kai Muller; Sikorski, Pawel (Journal article; Peer reviewed, 2013)Live cell arrays are an emerging tool that expand traditional 2D in vitro cell culture, increasing experimental precision and throughput. A patterned cell system was developed by combining the cell-repellent properties of ... -
A sample cell for the study of enzyme-induced carbonate precipitation at the grain-scale and its implications for biocementation
Zehner, Jennifer Simone; Røyne, Anja; Sikorski, Pawel (Journal article; Peer reviewed, 2021)Biocementation is commonly based on microbial-induced carbonate precipitation (MICP) or enzyme-induced carbonate precipitation (EICP), where biomineralization of CaCO3 in a granular medium is used to produce a sustainable, ... -
Seeing a Mycobacterium-Infected Cell in Nanoscale 3D: Correlative Imaging by Light Microscopy and FIB/SEM Tomography
Beckwith, Marianne; Beckwith, Kai Sandvold; Sikorski, Pawel; Skogaker, Nan Elisabeth Tostrup; Flo, Trude Helen; Halaas, Øyvind (Journal article; Peer reviewed, 2015)Mycobacteria pose a threat to the world health today, with pathogenic and opportunistic bacteria causing tuberculosis and non-tuberculous disease in large parts of the population. Much is still unknown about the interplay ... -
Stabilisation of amorphous calcium phosphate in polyethylene glycol hydrogels
Schweikle, Manuel; Bjørnøy, Sindre Hove; Van Helvoort, Antonius; Haugen, Håvard Jostein; Sikorski, Pawel; Tiainen, Hanna (Journal article; Peer reviewed, 2019)Acellular polymer-calcium phosphate composites are promising bone graft materials. Hydrogels are suitable for providing a temporary matrix, while calcium phosphate minerals serve as ion depots for calcium and phosphate ... -
Tailoring the assembly of collagen fibers in alginate microspheres
Lehnert, Sarah; Sikorski, Pawel (Peer reviewed; Journal article, 2021)The application of microspheres instead of bulk hydrogels in cell-laden biomaterials offers multiple advantages such as a high surface-to-volume-ratio and, consequently, a better nutrition and oxygen transfer to and from ... -
Towards a low CO2 emission building material employing bacterial metabolism (1/2): The bacterial system and prototype production
Røyne, Anja; Phua, Yi Jing; Le, Simone Balzer; Eikjeland, Ina Grosås; Josefsen, Kjell Domaas; Markussen, Sidsel; Myhr, Anders; Throne-Holst, Harald; Sikorski, Pawel; Wentzel, Alexander (Journal article; Peer reviewed, 2019)The production of concrete for construction purposes is a major source of anthropogenic CO2 emissions. One promising avenue towards a more sustainable construction industry is to make use of naturally occurring mineral-microbe ... -
Transformation of brushite to hydroxyapatite and effects of alginate additives
Ucar, Seniz; Bjørnøy, Sindre Hove; Bassett, David; Strand, Berit Løkensgard; Sikorski, Pawel; Andreassen, Jens-Petter (Journal article; Peer reviewed, 2016)Phase transformations are important processes during mineral formation in both in vivo and in vitro model systems and macromolecules are influential in regulating the mineralization processes. Calcium phosphate mineralized ... -
Tunable high aspect ratio polymer nanostructures for cell interfaces
Beckwith, Kai Sandvold; Cooil, Simon Phillip; Wells, Justin; Sikorski, Pawel (Journal article; Peer reviewed, 2015)Nanoscale topographies and chemical patterns can be used as synthetic cell interfaces with a range of applications including study and control of cellular processes. Herein, we describe the fabrication of high aspect ratio ... -
Versatile, cell and chip friendly method to gel alginate in microfluidic devices
Håti, Armend Gazmeno; Bassett, David; Ribe, Jonas Myren; Sikorski, Pawel; Weitz, David A.; Stokke, Bjørn Torger (Journal article, 2016)Alginate is used extensively in microfluidic devices to produce discrete beads or fibres at the microscale. Such structures may be used to encapsulate sensitive cargoes such as cells and biomolecules. On chip gelation of ...