Blar i NTNU Open på forfatter "Holzapfel, Gerhard"
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Numerical aspects of anisotropic failure in soft biological tissues favor energy-based criteria: A rate-dependent anisotropic crack phase-field model
Gultekin, Osman; Dal, Husnu; Holzapfel, Gerhard (Journal article; Peer reviewed, 2018)A deeper understanding to predict fracture in soft biological tissues is of crucial importance to better guide and improve medical monitoring, planning of surgical interventions and risk assessment of diseases such as ... -
Numerical modeling of diseased mitral valves
Aguilera, Hans Martin Dahl (Doctoral theses at NTNU;2023:273, Doctoral thesis, 2023)In this thesis, we have developed methods to create digital replicas of patients’ mitral valves from echocardiographic images and perform structural simulations in a finite element framework. The methods allow us to study ... -
On the quasi-incompressible finite element analysis of anisotropic hyperelastic materials
Gultekin, Osman; Dal, Husnu; Holzapfel, Gerhard (Journal article; Peer reviewed, 2018)Quasi-incompressible behavior is a desired feature in several constitutive models within the finite elasticity of solids, such as rubber-like materials and some fiber-reinforced soft biological tissues. The Q1P0 finite ... -
Perspectives on sharing models and related resources in computational biomechanics research
Erdemir, Ahmet; Hunter, Peter J; Holzapfel, Gerhard; Loew, Leslie M.; Middleton, John; Jacobs, Christopher R.; Nithiarasu, Perumal; Löhner, Rainald; Wei, Guowei; Winkelstein, Beth A.; Barocas, Victor H.; Guilak, Farshid; Ku, Joy P.; Hicks, Jennifer L.; Delp, Scott L.; Sacks, Michael; Weiss, Jeffrey A.; Ateshian, Gerard A.; Maas, Steve A.; McCulloch, Andrew D.; Peng, Grace C.Y. (Journal article; Peer reviewed, 2018)The role of computational modeling for biomechanics research and related clinical care will be increasingly prominent. The biomechanics community has been developing computational models routinely for exploration of the ... -
A phase-field model for fracture of unidirectional fiber-reinforced polymer matrix composites
Denli, Funda; Gultekin, Osman; Holzapfel, Gerhard; Dal, Husnu (Peer reviewed; Journal article, 2020)This study presents a crack phase-field approach for anisotropic continua to model, in particular, fracture of fiber-reinforced matrix composites. Starting with the variational formulation of the multi-field problem of ... -
A pilot in silico modeling-based study of the pathological effects on the biomechanical function of tricuspid valves
Laurence, Devin W.; Johnson, Emily L.; Hsu, Ming-Chen; Baumwart, Ryan; Mir, Arshid; Burkhart, Harold M.; Holzapfel, Gerhard; Wu, Yi; Lee, Chung-Hao (Peer reviewed; Journal article, 2020)Current clinical assessment of functional tricuspid valve regurgitation relies on metrics quantified from medical imaging modalities. Although these clinical methodologies are generally successful, the lack of detailed ... -
A pilot study on biaxial mechanical, collagen microstructural, and morphological characterizations of a resected human intracranial aneurysm tissue
Laurence, Devin W.; Homburg, Hannah; Yan, Feng; Tang, Qinggong; Fung, Kar-Ming; Bohnstedt, Bradley N.; Holzapfel, Gerhard; Lee, Chung-Hao (Journal article; Peer reviewed, 2021) -
Poro-Viscoelastic Effects During Biomechanical Testing of Human Brain Tissue
Greiner, Alexander; Reiter, Nina; Paulsen, Friedrich; Holzapfel, Gerhard; Steinmann, Paul; Comellas, Ester; Budday, Silvia (Peer reviewed; Journal article, 2021)Brain tissue is one of the softest tissues in the human body and the quantification of its mechanical properties has challenged scientists over the past decades. Associated experimental results in the literature have been ... -
Poro-viscoelastic material parameter identification of brain tissue-mimicking hydrogels
Kainz, Manuel P.; Greiner, Alexander; Hinrichsen, Jan; Kolb, Dagmar; Comellas, Ester; Steinmann, Paul; Budday, Silvia; Terzano, Michele; Holzapfel, Gerhard (Peer reviewed; Journal article, 2023)Understanding and characterizing the mechanical and structural properties of brain tissue is essential for developing and calibrating reliable material models. Based on the Theory of Porous Media, a novel nonlinear ... -
Rate-dependent mechanical behaviour of semilunar valves under biaxial deformation: From quasi-static to physiological loading rates
Anssari-Benam, Afshin; Tseng, Yuan-Tsan; Holzapfel, Gerhard; Bucchi, Andrea (Peer reviewed; Journal article, 2020)In this study we investigate the rate-dependency of the mechanical behaviour of semilunar heart valves under biaxial deformation, from quasi-static to physiological loading rates. This work extends and complements our ... -
The influence of fiber dispersion on the mechanical response of aortic tissues in health and disease: a computational study
Niestrawska, Justyna A; Ch Haspinger, Daniel; Holzapfel, Gerhard (Journal article; Peer reviewed, 2018)Changes in the structural components of aortic tissues have been shown to play a significant role in the pathogenesis of aortic degeneration. Therefore, reliable stress analyses require a suitable and meaningful constitutive ... -
Towards microstructure-informed material models for human brain tissue
Budday, S.; Sarem, M.; Starck, L.; Sommer, G.; Pfefferle, J.; Phunchago, N.; Kuhl, E.; Paulsen, F.; Steinmann, P.; Shastri, V.P.; Holzapfel, Gerhard (Peer reviewed; Journal article, 2020)Emerging evidence suggests that the mechanical behavior of the brain plays a critical role in development, disease, and aging. Recent studies have begun to characterize the mechanical behavior of gray and white matter ... -
Tricuspid Valve Regurgitation in Hypoplastic Left Heart Syndrome: Current Insights and Future Perspectives
Ross, Colton J.; Mir, Arshid; Burkhart, Harold M.; Holzapfel, Gerhard; Lee, Chung-Hao (Journal article; Peer reviewed, 2023)