• Multi-omic detection of Mycobacterium leprae in archaeological human dental calculus 

      Fotakis, Anna K.; Denham, Sean Dexter; Mackie, Meaghan; Orbegozo, Miren Iraeta; Mylopotamitaki, Dorothea; Gopalakrishnan, Shyam; Sicheritz-Pontén, Thomas; Olsen, Jesper V.; Cappellini, Enrico; Zhang, Guojie; Christophersen, Axel; Gilbert, Thomas; Vågene, Åshild J (Peer reviewed; Journal article, 2020)
      Mineralized dental plaque (calculus) has proven to be an excellent source of ancient biomolecules. Here we present a Mycobacterium leprae genome (6.6-fold), the causative agent of leprosy, recovered via shotgun sequencing ...
    • A multi-omics approach unravels metagenomic and metabolic alterations of a probiotic and synbiotic additive in rainbow trout (Oncorhynchus mykiss) 

      Rasmussen, Jacob Agerbo; Villumsen, Kasper Rømer; Ernst, Madeleine; Hansen, Martin; Forberg, Torunn; Gopalakrishnan, Shyam; Gilbert, Marcus Thomas Pius; Bojesen, Anders Miki; Kristiansen, Karstein; Limborg, Morten Tønsberg (Peer reviewed; Journal article, 2022)
      Background Animal protein production is increasingly looking towards microbiome-associated services such as the design of new and better probiotic solutions to further improve gut health and production sustainability. ...
    • Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain 

      van Dorp, Lucy; Gelabert, Pere; Rieux, Adrien; De Manuel, Marc; De-Dios, Toni; Gopalakrishnan, Shyam; Carøe, Christian; Sandoval-Velasco, Marcela; Fregel, Rosa; Olalde, Iñigo; Escosa, Raül; Aranda, Carles; Huijben, Silvie; Mueller, Ivo; Marques-Bonet, Tomas; Balloux, Francois; Gilbert, Marcus Thomas Pius; Lalueza-Fox, Carles (Peer reviewed; Journal article, 2020)
      The protozoan Plasmodium vivax is responsible for 42% of all cases of malaria outside Africa. The parasite is currently largely restricted to tropical and subtropical latitudes in Asia, Oceania, and the Americas. Though, ...
    • The population genomic legacy of the second plague pandemic 

      Gopalakrishnan, Shyam; Ebenesersdottir, S.Sunna; Lundstrøm, Inge K.C.; Turner-Walker, Gordon; Moore, Kristjan H.S.; Luisi, Pierre; Magaryan, Ashot; Martin, Michael D.; Ellegaard, Martin Rene; Magnusson, Olafur T.; Sigurdsson, Asgeir; Snorradóttir, Steinunn; Magnúsdóttir, Droplaug N.; Laffoon, Jason E.; van Dorp, Lucy; Liu, Xiaodong; Moltke, Ida; Avila-Arcos, María C.; Schraiber, Joshua G.; Rasmussen, Simon; Juan, David; Galabert, Pere; De-Dios, Toni; Fotakis, Anna K.; Iraeta-Orbegozo, Miren; Vågene, Åshild J.; Denham, Sean Dexter; Christophersen, Axel; Stenøien, Hans K.; Vieira, Filipe G.; Liu, Shanlin; Günther, Torsten; Kivisild, Toomas; Moseng, Ole Georg; Skar, Birgitte; Cheung, Christina; Sandoval-Velasco, Marcela; Wales, Nathan; Schroeder, Hannes; Campos, Paula F.; Gudmundsdottir, Valdis B; Sicheritz - Ponten, Thomas; Petersen, Bent; Halgunset, Jostein; Gilbert, Edmund; Cavalleri, Gianpiero L.; Hovig, Eivind; Kockum, Ingrid; Olsson, Tomas; Alfredsson, Lars; Hansen, Thomas F.; Werge, Thomas; Willerslev, Eske; Balloux, Francois; Marquès-Bonet, Tomás; Lalueza-Fox, Carles; Nielsen, Rasmus; Stefánsson, Kári; Helgason, Agnar; Gilbert, Thomas P. (Peer reviewed; Journal article, 2022)
      Human populations have been shaped by catastrophes that may have left long-lasting signatures in their genomes. One notable example is the second plague pandemic that entered Europe in ca. 1,347 CE and repeatedly returned ...
    • Population genomics of grey wolves and wolf-like canids in North America 

      Sinding, Mikkel Holger Strander; Gopalakrishnan, Shyam; Vieira, Filipe G.; Samaniego, Jose A; Raundrup, Katrine; Heide Jørgensen, Mads Peter; Meldgaard, Morten; Petersen, Bent; Sicheritz-Ponten, Thomas; Mikkelsen, Johan Brus; Marquard-Petersen, Ulf; Dietz, Rune; Sonne, Christian; Dalén, Love; Bachmann, Lutz; Wiig, Øystein; Hansen, Anders J.; Gilbert, Marcus Thomas Pius (Journal article; Peer reviewed, 2018)
      North America is currently home to a number of grey wolf (Canis lupus) and wolf-like canid populations, including the coyote (Canis latrans) and the taxonomically controversial red, Eastern timber and Great Lakes wolves. ...
    • Probing the genomic limits of de-extinction in the Christmas Island rat 

      Lin, Jianqing; Duchêne, David; Carøe, Christian; Smith, Oliver; Ciucani, Marta Maria; Niemann, Jonas; Richmond, Douglas; Greenwood, Alex D.; MacPhee, Ross; Zhang, Guojie; Gopalakrishnan, Shyam; Gilbert, Marcus Thomas Pius (Peer reviewed; Journal article, 2022)
      Three principal methods are under discussion as possible pathways to “true” de-extinction; i.e., back-breeding, cloning, and genetic engineering.1,2 Of these, while the latter approach is most likely to apply to the largest ...
    • Redefining the Evolutionary History of the Rock Dove, Columba livia, Using Whole Genome Sequences 

      Hernández-Alonso, Germán; Ramos-Madrigal, Jazmín; van Grouw, Hein; Ciucani, MartaMaria; Cavill, Emily Louisa; Sinding, Mikkel-Holger S.; Gopalakrishnan, Shyam; Pacheco, George; Gilbert, Marcus Thomas Pius (Peer reviewed; Journal article, 2023)
      The domestic pigeon's exceptional phenotypic diversity was key in developing Darwin's Theory of Evolution and establishing the concept of artificial selection. However, unlike its domestic counterpart, its wild progenitor, ...
    • Specialized sledge dogs accompanied Inuit dispersal across the North American Arctic 

      Ameen, Carly; Feuerborn, Tatiana R.; Brown, Sarah K.; Linderholm, Anna; Hulme-Beaman, Ardern; Lebrasseur, Ophelie; Sinding, Mikkel Holger Strander; Lounsberry, Zachary T.; Lin, Audrey T.; Appelt, Martin; Bachmann, Lutz; Betts, Matthew; Britton, Kate; Darwent, John; Dietz, Rune; Fredholm, Merethe; Gopalakrishnan, Shyam; Goruinova, Olga I.; Grønnow, Bjarne; Haile, James; Hallsson, Jón Hallsteinn; Harrison, Ramona; Heide-Jørgensen, Mads-Peter; Knecht, Rick; Losey, Robert J.; Masson-MacLean, Edouard; McGovern, Thomas H.; McMagnus-Fry, Ellen; Meldgaard, Morten; Midtdal, Åslaug; Moss, Madonna L.; Nikitin, Iurii G.; Nomokonova, Tatiana; Palsdottir, Albina Hulda; Perri, Angela; Popov, Aleksandr N.; Rankin, Lisa; Reuther, Joshua D.; Sablin, Mikhail V.; Schmidt, Anne Lisbeth; Shirar, Scott; Smiarowski, Konrad; Sonne, Christian; Stiner, Mary C.; Vasyukov, Mitya; West, Catherine F.; Ween, Gro Birgit; Wennerberg, Sanne Eline; Wiig, Øystein; Woollett, James; Dalén, Love; Hansen, Anders J.; Gilbert, Marcus Thomas Pius; Sacks, Benjamin N; Frantz, Laurent A.F.; Larson, Greger; Dobney, Keith; Darwent, Christyann M.; Evin, Allowen (Journal article; Peer reviewed, 2019)
      Domestic dogs have been central to life in the North American Arctic for millennia. The ancestors of the Inuit were the first to introduce the widespread usage of dog sledge transportation technology to the Americas, but ...
    • The wolf reference genome sequence (Canis lupus lupus) and its implications for Canis spp. population genomics 

      Gopalakrishnan, Shyam; Samaniego Castruita, José Alfredo; Sinding, Mikkel Holger Strander; Kuderna, Lukas FK; Räikkönen, Jannikke; Petersen, Bent; Sicheritz-Ponten, Thomas; Larson, Greger; Orlando, Ludovic; Marques-Bonet, Tomas; Hansen, Anders J.; Dalén, Love; Gilbert, Marcus Thomas Pius (Journal article; Peer reviewed, 2017)
      Background: An increasing number of studies are addressing the evolutionary genomics of dog domestication, principally through resequencing dog, wolf and related canid genomes. There is, however, only one de novo assembled ...
    • Travel Tales of a Worldwide Weed: Genomic Signatures of Plantago major L. Reveal Distinct Genotypic Groups With Links to Colonial Trade Routes 

      Iwanycki Ahlstrand, Natalie; Gopalakrishnan, Shyam; Vieira, Filipe G.; Bieker, Vanessa Carina; Meudt, Heidi M.; Dunbar-Co, Stephanie; Rothfels, Carl J.; Martinez-Swatson, Karen Agatha; Maldonado, Carla; Hassemer, Gustavo; Shipunov, Alexey; Bowers, M. Deane; Gardner, Elliot; Xu, Maonian; Ghorbani, Abdolbaset; Amano, Makoto; Grace, Olwen M.; Pringle, James S.; Bishop, Madonna; Manzanilla, Vincent; Cotrim, Helena; Blaney, Sean; Zubov, Dimitri; Choi, Hong-Keun; Yesil, Yeter; Bennett, Bruce; Vimolmangkang, Sornkanok; El-Seedi, Hesham R.; Staub, Peter O.; Li, Zhu; Boldbaatar, Delgerbat; Hislop, Michael; Caddy, Laura J.; Muasya, A. Muthama; Saslis-Lagoudakis, C. Haris; Gilbert, M. Thomas P.; Zerega, Nyree J. C.; Rønsted, Nina (Peer reviewed; Journal article, 2022)
      Retracing pathways of historical species introductions is fundamental to understanding the factors involved in the successful colonization and spread, centuries after a species’ establishment in an introduced range. Numerous ...
    • Uncovering neutral and adaptive genomic differentiation among European perch with brackish water and freshwater origin in the western Baltic Sea region 

      Skovrind, Mikkel; Pacheco, George; Christensen, Emil Aputsiaq Flindt; Gopalakrishnan, Shyam; Fietz, Katharina; Holm-Hansen, Tore Hejl; Vieira, Filipe Garrett; Krag, Marcus Anders; Carl, Henrik; Gilbert, Marcus Thomas Pius; Olsen, Morten Tange; Møller, Peter Daniel Rask (Peer reviewed; Journal article, 2023)
      Environmental variation across the range of wild species can lead to local adaptations. The Baltic Sea was formed when the Fenno-Scandian ice sheet retreated around 12 thousand years ago, creating a new brackish water ...
    • Uncovering the genomic basis of an extraordinary plant invasion 

      Bieker, Vanessa Carina; Battlay, Paul; Petersen, Bent; Sun, Xin; Wilson, Jonathan; Brealey, Jaelle C.; Bretagnolle, François; Nurkowski, Kristin; Lee, Chris; Sánchez Barreiro, Fatima; Owens, Gregory; Lee, Jacqueline; Kellner, Fabian Laszlo; van Boheeman, Lotte; Gopalakrishnan, Shyam; Gaudeul, Myriam; Mueller-Schaerer, Heinz; Lommen, Suzanne; Karrer, Gerhard; Chauvel, Bruno; Sun, Yan; Konstantinovic, Bojan; Dalén, Love; Poczai, Péter; Rieseberg, Loren H.; Gilbert, Marcus Thomas Pius; Hodgins, Kathryn A.; Martin, Michael David (Peer reviewed; Journal article, 2022)
      Invasive species are a key driver of the global biodiversity crisis, but the drivers of invasiveness, including the role of pathogens, remain debated. We investigated the genomic basis of invasiveness in Ambrosia artemisiifolia ...
    • Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites 

      Liu, Yan-Hu; Wang, Lu; Xu, Tao; Guo, Xiaomin; Li, Yang; Yin, Ting-Ting; Yang, He-Chuan; Hu, Yang; Adeola, Adeniyi C.; Sanke, Oscar J.; Otecko, Newton O.; Wang, Meng; Ma, Yaping; Charles, Olaogun S.; Sinding, Mikkel Holger Strander; Gopalakrishnan, Shyam; Samaniego, José Alfredo; Hansen, Anders J.; Fernandes, Carlos; Gaubert, Philippe; Budd, Jane; Dawuda, Philip M.; Rueness, Eli Knispel; Jiang, Lubin; Zhai, Weiwei; Gilbert, Marcus Thomas Pius; Peng, Min-Sheng; Qi, Xiaopeng; Wang, Guo-Dong; Zhang, Ya-ping (Journal article; Peer reviewed, 2017)
      Natural selection in domestic dogs is of great interest in evolutionary biology since dogs have migrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. Here, we explored ...