Blar i NTNU Open på forfatter "Draget, Kurt Ingar"
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Is dehulling of peas and faba beans necessary prior to dry fractionation for the production of protein- and starch-rich fractions? Impact on physical properties, chemical composition and techno-functional properties
do Carmo, Cátia Saldanha; Silventoinen, Pia; Nordgård, Catherine Taylor; Poudroux, Claire; Dessev, Tzevetelin; Zobel, Hanne; Holtekjølen, Ann Katrin; Draget, Kurt Ingar; Holopainen-Mantila, Ulla; Knutsen, Svein Halvor; Sahlstrøm, Stefan (Journal article; Peer reviewed, 2020)Dehulling of peas and faba beans prior to milling and air classification was evaluated, namely its impact on physical properties, chemical composition and techno-functional properties of the fractions. Dry fractionation ... -
Levering av vannløselige molekyler gjennom hud: Diffusjon av molekyler gjennom stratum corneum
Eiken, Karianne Birkestøl (Master thesis, 2011)En transdermal leveringsform gir store fordeler framfor oral, intramuskulær og intravenøs levering, men byr også på noen utfordringer. Den største utfordringen er at kun et begrenset antall molekyler kan administreres på ... -
Mechanical properties of 67NR tumours are broadly independent of the immune status of the host mouse
Nordgård, Catherine Taylor; Rao, Shalini Vasudev; Dille, Morten Johnsen; Steigedal, Tonje S.; Draget, Kurt Ingar (Journal article; Peer reviewed, 2017)Tumour stiffness is increasingly seen as a clinically relevant parameter, with increased stiffness being linked to poorer prognosis, but it is also one that is not inherently easy to measure either in vivo or ex vivo. We ... -
Mechanism of Action of G-blocks: Is calcium involved?
Røe, Marit Vaagen (Master thesis, 2013)The mucus barrier coats the internal surfaces in the body and is one of nature?s success stories. Due to the physiological importance of it there has been extensive research on mucus and mucins for decades. Several mechanisms ... -
Modulation of calcium-induced gelation of pectin by oligoguluronate as compared to alginate
Zhang, Bangheng; Hu, Bing; Nakauma, Makoto; Funami, Takahiro; Nishinari, Katsuyoshi; Draget, Kurt Ingar; Phillips, Glyn O.; Fang, Yapeng (Journal article; Peer reviewed, 2018)Previous studies have demonstrated that oligoguluronate (guluronate block extracted from alginate, GB) was an efficient modulator of the gelation and gelling properties of macromolecular alginate in the presence of calcium. ... -
Mucus barrier components, challenges for nanoscale drug delivery
Jalalian Javadpour, Hamid (Master thesis, 2013)In this present study changes in nanoparticles motion were explored in the presence and the absence of G-blocks in mucus matrices such as; porcine gastric mucus (45 mg/ml), and a mixture of porcine gastric mucus + polymeric ... -
Nanoparticle Mobility in Pig Small Intestine Mucus (PSIM) - Optimization of Methods used to study Diffusion of Nanoparticles through PSIM, and the Effect of G-block
Wien, Ingrid (Master thesis, 2015)In this thesis, methods for studying diffusion of nanoparticles through pig small intestine mucus (PSIM) were to be studied and optimized. The nanoparticles used were different types of FluoSpheres® and also rhodamine ... -
Optimizing Emulsions for More Efficient Uptake of Lipophilic Compounds
Baydin, Tuna (Master thesis, 2018)Lipid based oral drug delivery systems provide a spectrum of formulations for the delivery of poorly water soluble compounds. When naturally occurring lipid molecules are utilized in these systems, in addition to being ... -
Particle Mobility in Mucus: Role of Surface Interactions and Use of G-blocks
Jyssum, Kari (Master thesis, 2012)The mucus layers on the internal surfaces of the human body serve as an important barrier against foreign material, but it also create restrictions regarding drug delivery. Discovering methods to overcome this barrier would ... -
Penetrating the Mucus Barrier - The Effect of Addition of Guluronate Oligomers on the Mobility of Nanoparticles in Porcine Small Intestinal Mucus
Sørensen, Solveig Lysfjord (Master thesis, 2015)Oral delivery is the easiest and most used method of drug delivery. However, the gastrointestinal (GI) tract poses many hurdles for the drugs to overcome before they can reach their target. One of them is the viscous, ... -
Physical and functional properties of plant-based pre-emulsified chewable gels for the oral delivery of nutraceuticals
Baydin, Tuna; Arntsen, Stine Wold; Hattrem, Magnus Nergård; Draget, Kurt Ingar (Peer reviewed; Journal article, 2022)Gelatin-based pre-emulsified chewable gels have presented advantages over traditional tablets, bulk oils, hard and soft capsules for oral delivery. Ethical, ecological, and religious considerations have increased the demand ... -
Physical properties of gelatin based solid emulsions: Effects on drug release in the GI tract
Molnes, Silje Nedland (Master thesis, 2013)Oral administration of pharmaceuticals is a convenient and simple route for drug delivery. Due to challenges concerning patient compliance and bioavailability, there has been exerted a great effort the last couple of years ... -
Potential mucus rheological consequences of off target siRNA loaded nanoparticle deposition in the lungs
Katuwal, Nishan; Loretz, Brigitte; Thanki, Kaushik; Hållbrink, Mattias; Lehr, Claus-Michael; Foged, Camilla; Draget, Kurt Ingar; Nordgård, Catherine Taylor (Journal article; Peer reviewed, 2018) -
Soft, chewable gelatin-based pharmaceutical oral formulations: a technical approach
Dille, Morten Johnsen; Hattrem, Magnus Nergård; Draget, Kurt Ingar (Journal article; Peer reviewed, 2018) -
The Effect of Alginate G-block Treatment on the Extracellular Matrix
Tønnesson, Trine (Master thesis, 2018)Dense extracellular matrix and alterations of extracellular matrix are two of the hallmarks of solid tumors. The resulting highly fibrotic extracellular matrix is associated with several types of cancer. These solid tumors ... -
The Effect of G-block on the Extracellular Matrix Barrier to Molecular Diffusion
Wøien, Stine Malene Hansen (Master thesis, 2015)Changes in extracellular matrix (ECM) are one of the characteristics of solid tumours. Many types of cancers associated with high mortality rates develop solid tumours with an extensive fibrotic extracellular matrix. Over ... -
The Effects of Nanoparticle Drug Delivery Formulations on the Rheological Properties of Mucus
Katuwal, Nishan (Master thesis, 2017)The aerosol technology used in lungs drug delivery is not precise enough to target all the drugs to alveoli. Some off target deposition of nanoparticles occurs in airway mucus. In general, mucociliary clearance is capable ... -
The Mucin-Alginate Interplay: Investigating the Rheological Impact of Alginates and Their Influence on Particle Mobility
Reehorst, Camilla M (Master thesis, 2014)Mucus is a hydrogel that covers epithelial cells and acts as an intermediary between the exterior and interior surfaces of the human body. It is complex and diverse, comprised of various compounds and serves as a selective ... -
The potential of marine oligosaccharides in pharmacy
Nordgård, Catherine Taylor; Rao, Shalini Vasudev; Draget, Kurt Ingar (Journal article; Peer reviewed, 2019)Complex polysaccharides are widespread within the animal kingdom. At the molecular level, however, the importance of such components have largely been considered inferior compared to nucleic acids and proteins. This in ... -
The Relative Bioavailability of Ibuprofen After Administration With a Novel Soft Chewable Drug Formulation
Hattrem, Magnus Nergård; Dille, Morten Johnsen; Seternes, Tore; Ege, Thorfinn; Draget, Kurt Ingar (Journal article; Peer reviewed, 2017)The first aim of the present study was to evaluate the bioavailability of ibuprofen dispersed in a novel soft chewable formulation compared with a traditional ibuprofen tablet; its second was to map the quality of taste ...