Browsing NTNU Open by Author "Davies, Neil Martin"

Now showing items 21-28 of 28

    • Population phenomena inflate genetic associations of complex social traits 

      Morris, Tim T; Davies, Neil Martin; Hemani, Gibran; Davey-Smith, George (Peer reviewed; Journal article, 2020)
      Heritability, genetic correlation, and genetic associations estimated from samples of unrelated individuals are often perceived as confirmation that genotype causes the phenotype(s). However, these estimates can arise from ...

    • Quantifying the causal impact of biological risk factors on healthcare costs 

      Lee, Jiwoo; Jukarainen, Sakari; Karvanen, Antti; Dixon, Padraig; Davies, Neil Martin; Smith, George Davey; Natarajan, Pradeep; Ganna, Andrea (Peer reviewed; Journal article, 2023)
      Understanding the causal impact that clinical risk factors have on healthcare-related costs is critical to evaluate healthcare interventions. Here, we used a genetically-informed design, Mendelian Randomization (MR), to ...

    • Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes 

      Walker, Venexia M.; Vujkovic, Marijana; Carter, Alice R.; Davies, Neil Martin; Udler, Miriam S.; Levin, Michael G.; Davey Smith, George; Voight, Benjamin F.; Gaunt, Tom R.; Damrauer, Scott M. (Peer reviewed; Journal article, 2022)
      Aims/hypothesis Type 2 diabetes and atherosclerotic CVD share many risk factors. This study aimed to systematically assess a broad range of continuous traits to separate their direct effects on coronary and peripheral ...

    • Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study 

      Howe, Laurence J.; Brumpton, Ben Michael; Rasheed, Humaira; Åsvold, Bjørn Olav; Davey Smith, George; Davies, Neil Martin (Peer reviewed; Journal article, 2022)
      Background: Taller people have a lower risk of coronary heart disease but a higher risk of many cancers. Mendelian randomization (MR) studies in unrelated individuals (population MR) have suggested that these relationships ...

    • Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank 

      Harrison, Sean; Davies, Neil Martin; Howe, Laura D.; Hughes, Amanda (Peer reviewed; Journal article, 2021)
      Men with more advantaged socioeconomic position (SEP) have been observed to have higher levels of testosterone. It is unclear whether these associations arise because testosterone has a causal impact on SEP. In 306,248 ...

    • Varenicline versus nicotine replacement therapy for long-term smoking cessation: an observational study using the Clinical Practice Research Datalink 

      Davies, Neil Martin; Taylor, Amy E.; Taylor, Gemma M.J.; Itani, Taha; Jones, Tim; Martin, Richard M.; Munafò, Marcus R.; Windmeijer, Frank; Thomas, Kyla H. (Peer reviewed; Journal article, 2020)
      Background Smoking is the leading avoidable cause of illness and premature mortality. The first-line treatments for smoking cessation are nicotine replacement therapy and varenicline. Meta-analyses of experimental studies ...

    • Weakening of the cognition and height association from 1957 to 2018: Findings from four British birth cohort studies 

      Bann, David; Wright, Liam; Davies, Neil Martin; Moulton, Vanessa (Peer reviewed; Journal article, 2023)
      Background: Taller individuals have been repeatedly found to have higher scores on cognitive assessments. Recent studies have suggested that this association can be explained by genetic factors, yet this does not preclude ...

    • Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects 

      Howe, Laurence J.; Nivard, Michel G.; Morris, Tim T.; Hansen, Ailin Falkmo; Rasheed, Humaira; Cho, Yoonsu; Chittoor, Geetha; Ahlskog, Rafael; Lind, Penelope A.; Palviainen, Teemu; van der Zee, Matthijs D.; Cheesman, Rosa Catherine Gillespie; Mangino, Massimo; Wang, Yunzhang; Li, Shuai; Klaric, Lucija; Ratliff, Scott M.; Bielak, Lawrence F.; Nygaard, Marianne; Giannelis, Alexandros; Willoughby, Emily A.; Reynolds, Chandra A.; Balbona, Jared V.; Andreassen, Ole; Ask, Helga; Baras, Aris; Bauer, Christopher R.; Boomsma, Dorret I.; Campbell, Archie; Campbell, Harry; Chen, Zhengming; Christofidou, Paraskevi; Corfield, Elizabeth Claire; Dahm, Christina C.; Dokuru, Deepika R.; Evans, Luke M.; de Geus, Eco J. C.; Giddaluru, Sudheer; Gordon, Scott D.; Harden, K. Paige; Hill, W. David; Hughes, Amanda; Kerr, Shona M.; Kim, Yongkang; Kweon, Hyeokmoon; Latvala, Antti; Lawlor, Deborah A.; Li, Liming; Lin, Kuang; Magnus, Per Minor; Magnusson, Patrik K. E.; Mallard, Travis T.; Martikainen, Pekka; Mills, Melinda C.; Njølstad, Pål Rasmus; Overton, John D.; Pedersen, Nancy L.; Porteous, David J.; Reid, Jeffrey; Silventoinen, Karri; Southey, Melissa C.; Stoltenberg, Camilla; Tucker-Drob, Elliot M.; Wright, Margaret J.; Kweon, Hyeokmoon; Koellinger, Philipp D.; Benjamin, Daniel J.; Turley, Patrick; Howe, Laurence J.; Nivard, Michel G.; Morris, Tim T.; Plomin, Robert; Havdahl, Alexandra; Bartels, Meike; Martin, Nicholas G.; Oskarsson, Sven; Justice, Anne E.; Millwood, Iona Y.; Hveem, Kristian; Willer, Cristen J.; Åsvold, Bjørn Olav; Kaprio, Jaakko; Medland, Sarah E.; Walters, Robin G.; Evans, David M.; Smith, George Davey; Hayward, Caroline; Brumpton, Ben; Hemani, Gibran; Davies, Neil Martin; Hewitt, John K.; Keller, Matthew C.; Stallings, Michael C.; Lee, James J.; Christensen, Kaare; Kardia, Sharon L. R.; Peyser, Patricia A.; Smith, Jennifer A.; Wilson, James F.; Hopper, John L.; Hägg, Sara; Spector, Tim D.; Pingault, Jean-Baptiste; Næss, Øyvind Erik; Davey Smith, George; Brumpton, Ben Michael (Peer reviewed; Journal article, 2022)
      Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect ...