• GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer 

      Zhou, Wei; Brumpton, Ben Michael; Kabil, Omer; Gudmundsson, Julius; Thorleifsson, Gudmar; Weinstock, Joshua; Zawistowski, Matthew; Nielsen, Jonas Bille; Chaker, Layal; Medici, Marco; Teumer, Alexander; Naitza, Silvia; Sanna, Serena; Schultheiss, Ulla T.; Cappola, Anne R.; Karjalainen, Juha; Kurki, Mitja I.; Oneka, Morgan; Taylor, Peter; Fritsche, Lars; Graham, Sarah E.; Wolford, Brooke N.; Overton, William; Rasheed, Humaira; Bordal, Eirin Haug; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi; Surakka, Ida; Davey Smith, George; Pandit, Anita; Roychowdhury, Tanmoy; Hornsby, Whitney; Jonasson, Jon G.; Senter, Leigha; Liyanarachchi, Sandya; Ringel, Matthew D.; Xu, Li; Kiemeney, Lambertus A.; He, Huiling; Netea-Maier, Romana; Mayordomo, Jose; Plantinga, Theo S.; Hrafnkelsson, Jon; Hjartarson, Hannes; Sturgis, Erich M.; Palotie, Aarno; Daly, Mark J.; Citterio, Cintia E.; Arvan, Peter; Brummett, Chad M.; Boehnke, Michael; de la Chapelle, Albert; Stefansson, Kari; Hveem, Kristian; Willer, Cristen J.; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2020)
      Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to ...
    • Intake of multivitamin supplements and incident asthma in Norwegian adults: the HUNT study 

      Jiang, Lin; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Mai, Xiao-Mei (Journal article; Peer reviewed, 2015)
      Although intake of multivitamin supplements is becoming increasingly popular, the relationship between intake of multivitamin supplements and incident asthma remains unclear. Prospective studies in adults with long-term ...
    • Investigating causal relations between sleep traits and risk of breast cancer in women: Mendelian randomisation study 

      Richmond, Rebecca C.; Anderson, Emma L.; Dashti, Hassan S.; Jones, Samuel E.; Lane, Jacqueline M.; Strand, Linn B; Brumpton, Ben Michael; Rutter, Martin K.; Wood, Andrew R.; Straif, Kurt; Relton, Caroline L.; Munafò, Marcus; Frayling, Timothy M.; Martin, Richard M.; Saxena, Richa; Weedon, Michael N.; Lawlor, Debbie A.; Smith, George Davey (Peer reviewed; Journal article, 2019)
      Objective To examine whether sleep traits have a causal effect on risk of breast cancer. Design Mendelian randomisation study. Setting UK Biobank prospective cohort study and Breast Cancer Association Consortium ...
    • Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis 

      Anderson, Emma L.; Richmond, Rebecca C.; Jones, Samuel E.; Hemani, Gibran; Wade, Kaitlin H; Dashti, Hassan S.; Lane, Jaqueline; Wang, Heming; Saxena, Richa; Brumpton, Ben Michael; Korologou-Linden, Roxanna; Nielsen, Jonas Bille; Åsvold, Bjørn Olav; Abecasis, Goncalo; Coulthard, Elizabeth; Kyle, Simon D.; Beaumont, Robin N.; Tyrell, Jessica; Frayling, Timothy M; Munafo, Marcus R; Wood, Andrew R; Ben-Shlomo, Yoav; Howe, Laura D; Lawlor, Deborah A.; Weedon, Michael N; Smith, George Davey (Peer reviewed; Journal article, 2020)
      Background It is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset ...
    • Is having asthma associated with an increased risk of dying from cardiovascular disease? A prospective cohort study of 446 346 Taiwanese adults 

      Strand, Linn B; Tsai, Min Kuang; Wen, Chi Pang; Chang, Shu-Sen; Brumpton, Ben Michael (Journal article; Peer reviewed, 2018)
      Objectives A significant proportion of cardiovascular disease (CVD) cannot be explained by well-known risk factors such as high cholesterol, hypertension and diabetes. One potential novel risk factor for CVD is asthma. We ...
    • Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort 

      Moen, Gunn-Helen; Brumpton, Ben Michael; Willer, Cristen J.; Åsvold, Bjørn Olav; Birkeland, Kåre I.; Wang, Geng; Neale, Michael C.; Freathy, Rachel M.; Smith, George Davey; Lawlor, Debbie A.; Kirkpatrick, Robert M.; Warrington, Nicole Maree; Evans, David M. (Peer reviewed; Journal article, 2020)
      There is a robust observational relationship between lower birthweight and higher risk of cardiometabolic disease in later life. The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that adverse ...
    • MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk 

      Surakka, Ida; Fritsche, Lars; Zhou, Wei; Backman, Joshua; Kosmicki, Jack A.; Lu, Haocheng; Brumpton, Ben Michael; Nielsen, Jonas B.; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi; Wolford, Brooke N.; Graham, Sarah E.; Chen, Y. Eugene; Lee, Seunggeun; Kang, Hyun Min; Langhammer, Arnulf; Forsmo, Siri; Åsvold, Bjørn Olav; Styrkarsdottir, Unnur; Holm, Hilma; Gudbjartsson, Daniel F.; Stefansson, Kari; Baras, Aris; Bai, Xiaodong; Balasubramanian, Suganthi; Barnard, Leland; Blumenfeld, Andrew; Cantor, Michael; Coppola, Giovanni; Economides, Aris; Eom, Gisu; Habegger, Lukas; Hahn, Young; Hawes, Alicia; Jones, Marcus B.; Khalid, Shareef; Lotta, Luca A.; Maxwell, Evan K.; Mitnaul, Lyndon J.; Overton, John D.; Reid, Jeffrey G.; Ferreira, Manuel Allen Revez; Salerno, William; Sharma, Deepika; Shuldiner, Alan R.; Staples, Jeffrey C.; Yadav, Ashish; Abecasis, Goncalo R.; Hveem, Kristian; Willer, Cristen J. (Peer reviewed; Journal article, 2020)
      A major challenge in genetic association studies is that most associated variants fall in the non-coding part of the human genome. We searched for variants associated with bone mineral density (BMD) after enriching the ...
    • Metabolic syndrome and incidence of asthma in adults: the HUNT study 

      Brumpton, Ben Michael; Camargo, Carlos; Romundstad, Pål Richard; Langhammer, Arnulf; Chen, Yue; Mai, Xiao-Mei (Journal article; Peer reviewed, 2013)
      Obesity is a risk factor for incident asthma in adults, and obesity is a major component of metabolic syndrome. This study aimed to explore the associations of metabolic syndrome and its components with the cumulative ...
    • Mitochondrial genome-wide association study of migraine – the HUNT Study 

      Børte, Sigrid; Zwart, John-Anker; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Thomas, Laurent; Fritsche, Lars G; Surakke, Ida; Nielsen, Jonas B.; Zhou, Wei; Wolford, Brooke; Vigeland, Magnus Dehli; Hagen, Knut; Kristoffersen, Espen Saxhaug; Nyholt, Dale R; Chasman, Daniel I; Brumpton, Ben Michael; Willer, Christen; Winsvold, Bendik K S (Peer reviewed; Journal article, 2020)
      Background Variation in mitochondrial DNA (mtDNA) has been indicated in migraine pathogenesis, but genetic studies to date have focused on candidate variants, with sparse findings. We aimed to perform the first mitochondrial ...
    • Physical Activity and Incident Asthma in Adults: The HUNT Study, Norway. 

      Brumpton, Ben Michael; Langhammer, Arnulf; Ferreira, Manuel A R; Chen, Yue; Mai, Xiao-Mei (Journal article; Peer reviewed, 2016)
      Objective: We aimed to investigate the associations of physical activity and change in physical activity with incident asthma in a cohort of Norwegian adults. Design: We conducted a prospective cohort study using ...
    • Prolonged Sitting, Its Combination With Physical Inactivity and Incidence of Lung Cancer: Prospective Data From the HUNT Study 

      Jiang, Lin; Sun, Yi-Qian; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Nilsen, Tom Ivar Lund; Mai, Xiao-Mei (Journal article; Peer reviewed, 2019)
      Background: Prolonged sitting as a major sedentary behavior potentially contributes to illness, but its relation with lung cancer risk is unclear. Prolonged sitting can be presented in physically active or inactive ...
    • Separating the genetics of childhood and adult obesity: a validation study of genetic scores for body mass index in adolescence and adulthood in the HUNT Study 

      Brandkvist, Maria Charlotta; Bjørngaard, Johan Håkon; Ødegård, Rønnaug; Åsvold, Bjørn Olav; Smith, George Davey; Brumpton, Ben Michael; Hveem, Kristian; Richardson, Tom G.; Vie, Gunnhild Åberge (Peer reviewed; Journal article, 2020)
      From a life-course perspective, genetic and environmental factors driving childhood obesity may have a lasting inf luence on health later in life. However, how obesity trajectories vary throughout the life-course remains ...
    • Serum 25-hydroxyvitamin D level, smoking and lung function in adults: the HUNT Study 

      Larose, Tricia L; Brumpton, Ben Michael; Langhammer, Arnulf; Camargo, Carlos A; Chen, Yue; Romundstad, Pål Richard; Mai, Xiao-Mei (Journal article; Peer reviewed, 2015)
      The association between serum 25-hydroxyvitamin D (25(OH)D) level and lung function changes in the general population remains unclear. We conducted cross-sectional (n=1220) and follow-up (n=869) studies to investigate ...
    • Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomization analysis of the HUNT study 

      Sun, Yi-Qian; Brumpton, Ben Michael; Bonilla, Carolina; Lewis, Sarah J.; Burgess, Stephen; Skorpen, Frank; Chen, Yue; Nilsen, Tom Ivar Lund; Romundstad, Pål Richard; Mai, Xiao-Mei (Journal article; Peer reviewed, 2018)
      We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D [25(OH)D] levels and incidence of lung cancer overall and histologic types. We performed a Mendelian randomization (MR) analysis using ...
    • Sex differences in asthma control: the HUNT study 

      Le, Mary (Master thesis, 2016)
      Background: Asthma control is hypothesized to be influenced by sex; however, studies investigating sex differences in asthma control are few and results are conflicting. Objective: To our knowledge, no published peer-reviewed ...
    • Systematic assessment of prescribed medications and short-term risk of myocardial infarction - a pharmacopeia-wide association study from Norway and Sweden 

      Sen, Abhijit; Vardaxis, Ioannis; Lindqvist, Bo Henry; Brumpton, Ben Michael; Strand, Linn B; Bakken, Inger Johanne Landsjøåsen; Vatten, Lars Johan; Romundstad, Pål Richard; Ljung, Rickard; Mukamal, Kenneth Jay; Janszky, Imre (Journal article; Peer reviewed, 2019)
      Wholesale, unbiased assessment of Scandinavian electronic health-care databases offer a unique opportunity to reveal potentially important undiscovered drug side effects. We examined the short-term risk of acute myocardial ...
    • The association between dynamic lung volume and peak oxygen uptake in a healthy general population: the HUNT study 

      Rasch-Halvorsen, Øystein; Steinshamn, Sigurd Loe; Hassel, Erlend; Brumpton, Ben Michael; Langhammer, Arnulf (Journal article; Peer reviewed, 2019)
      Background Although dynamic lung volume is not considered a limiting factor of peak oxygen uptake (VO2peak) in healthy subjects, an association between forced expiratory lung volume in one second (FEV1) and VO2peak has ...
    • The Association of Bone Mineral Density with Mortality in a COPD Cohort. The HUNT Study, Norway 

      Vikjord, Sigrid Anna; Brumpton, Ben Michael; Mai, Xiao-Mei; Bhatta, Laxmi; Vanfleteren, Lowie E.G.W.; Langhammer, Arnulf (Journal article; Peer reviewed, 2019)
      In individuals with chronic obstructive pulmonary disease (COPD), the presence of comorbidities is associated with increased mortality risk. We wanted to study the association between bone mineral density (BMD) and mortality ...
    • The associations of anxiety and depression symptoms with weight change and incident obesity: The HUNT Study 

      Brumpton, Ben Michael; Langhammer, Arnulf; Romundstad, Pål Richard; Chen, Yue; Mai, Xiao-Mei (Journal article; Peer reviewed, 2013)
      OBJECTIVE: To investigate the associations of anxiety and depression symptoms with weight change and incident obesity in men and women. DESIGN: We conducted a prospective cohort study using the Norwegian Nord-Trøndelag ...
    • The joint association of anxiety, depression and obesity with incident asthma in adults: the HUNT Study 

      Brumpton, Ben Michael; Leivseth, Linda; Romundstad, Pål Richard; Langhammer, Arnulf; Chen, Yue; Camargo, Carlos; Mai, Xiao-Mei (Journal article; Peer reviewed, 2013)
      Background Anxiety or depression symptoms may increase the risk of developing asthma, and their interaction with obesity is not known. We aimed to assess the association of anxiety or depression symptoms and the joint ...