Browsing NTNU Open by Author "Brodtkorb, Eylert"

Now showing items 21-34 of 34

    • Mechanisms underlying aggressive behavior induced by antiepileptic drugs: Focus on topiramate, levetiracetam, and perampanel 

      Hansen, Cerine Corin; Ljung, Hanna; Brodtkorb, Eylert; Reimers, Arne (Journal article; Peer reviewed, 2018)
      Antiepileptic drugs (AEDs) are effective against seizures, but their use is often limited by adverse effects, among them psychiatric and behavioral ones including aggressive behavior (AB). Knowledge of the incidence, risk ...

    • Mental health and health related quality of life in mitochondrial POLG disease 

      Hikmat, Omar; Vederhus, Bente Johanne; Benestad, Merete Roineland; Engeset, Ida Malen E.; Klingenberg, Claus; Rasmussen, Magnhild; Tallaksen, Chantal; Brodtkorb, Eylert; Elgen, Irene Bircow; Bindoff, Laurence (Peer reviewed; Journal article, 2020)
      We aimed to assess the impact of POLG disease on mental health and quality of life in 15 patients using the Symptom Checklist-90-R (SCL-90-R) and Short-Form 36 Health Survey (RAND-36). We found increased scores in all nine ...

    • Pharmacokinetic data on brivaracetam, lacosamide and Perampanel during pregnancy and lactation 

      Landmark, Cecilie Johannessen; Rektorlie, Lene; Burns, Margrete Larsen; Revdal, Eline; Johannessen, Svein Ivar; Brodtkorb, Eylert (Peer reviewed; Journal article, 2021)
      We present pharmacokinetic data during pregnancy and lactation for brivaracetam, lacosamide and perampanel based on two case studies. Patient 1 used brivaracetam as monotherapy and gave birth to twins. Patient 2 used a ...

    • Psychiatric Comorbidity in Epilepsy 

      Revdal, Eline (Doctoral theses at NTNU;2024:146, Doctoral thesis, 2024)
      Epilepsy is a disease of the brain defined by recurrent epileptic seizures with various clinical presentations. The disorder has neurobiological, cognitive, psychological, and social consequences. Many of the epilepsies ...

    • Psychiatric comorbidity in relation to clinical characteristics of epilepsy: A retrospective observational study 

      Revdal, Eline; Kolstad, Bjørn Patrick; Winsvold, Bendik Kristoffer Slagsvold; Selmer, Kaja Kristine; Morken, Gunnar; Brodtkorb, Eylert (Peer reviewed; Journal article, 2023)
      Purpose Prevalence of psychiatric disorders in people with epilepsy is high. However, diagnostic validity and information about the nature of the seizure disorders are often poor in population-based studies. In a well ...

    • Recurrent malignant ventricular arrhythmias and paresthesia—a mystery revealed as aconitine poisoning: a case report 

      Mjølstad, Ole Christian; Radtke, Maria Anita; Brodtkorb, Eylert; Edvardsen, Frode; Wenche Rødseth, Brede; Aamo, Trond Oskar; Jacobsen, Dag; Stokke, Mathis Korseberg; Helland, Arne (Peer reviewed; Journal article, 2023)
      Background: We report a case of a clinical challenge lasting for 12 months, with severe and unresolved clinical features involving several medical disciplines. Case presentation: A 53-year-old Caucasian male, who had been ...

    • Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines 

      Reimers, Arne; Berg, Jon Andsnes; Burns, Margrete Larsen; Brodtkorb, Eylert; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Journal article; Peer reviewed, 2018)
      Background and objective: Laboratories sometimes use different reference ranges for the same antiepileptic drug (AED), particularly for new and poorly investigated drugs. This may contribute to misunderstandings, concerns ...

    • Remarkable effect of transdermal nicotine in children with CHRNA4- related autosomal dominant sleep-related hypermotor epilepsy 

      Lossius, Kristine; de Saint Martin, Anne; Myren-Svelstad, Sverre; Bjørnvold, Marit; Minken, Guro; Seegmuller, Caroline; Valenti Hirsch, Maria Paola; Chelly, Jamel; Steinlein, Ortrud; Picard, Fabienne; Brodtkorb, Eylert (Peer reviewed; Journal article, 2020)
      Objective Autosomal dominant sleep-related hypermotor epilepsy (ADSHE) is characterized by hypermotor seizures and may be caused by gain-of-function mutations affecting the nicotinic acetylcholine receptor (nAChR). Benefit ...

    • Seizure Precipitants 

      Samsonsen, Christian (Doctoral theses at NTNU;2017:214, Doctoral thesis, 2017)
      In the comprehensive management of epilepsy, both preventive pharmacological treatment and awareness of possible seizure precipitating factors are important. The true cause of seizure generation is often hard to disentangle, ...

    • Simplifying the clinical classification of polymerase gamma (POLG) disease based on age of onset; studies using a cohort of 155 cases 

      Hikmat, Omar; Naess, Karin; Engvall, Martin; Klingenberg, Claus; Rasmussen, Magnhild; Tallaksen, Chantal; Brodtkorb, Eylert; Østergaard, Elsebet; de Coo, Irenaeus F.M.; Pias-Peleteiro, Leticia; Isohanni, Pirjo; Uusimaa, Johanna; Darin, Niklas; Rahman, Shamima; Bindoff, Laurence (Peer reviewed; Journal article, 2020)
      Background Variants in POLG are one of the most common causes of inherited mitochondrial disease. Phenotypic classification of POLG disease has evolved haphazardly making it complicated and difficult to implement in ...

    • The cascade of seizure precipitants 

      Mestvedthagen, Guro (Master thesis, 2022)
      Samspillet mellom faktorer som utløser epileptiske anfall Bakgrunn: God og helhetlig behandling av epilepsi består både av forebyggende legemidler og å unngå anfallsutløsende faktorer. Ulike anfallsutløsende faktorer kan ...

    • The Impact of Pharmacokinetic Interactions with Eslicarbazepine Acetate Versus Oxcarbazepine and Carbamazepine in Clinical Practice 

      Landmark, Cecilie Johannessen; Svendsen, Torleiv; Dinarevic, Jasmin; Kufaas, Ruben F.; Reimers, Arne; Brodtkorb, Eylert; Baftiu, Arton; Burns, Margrete Larsen; Johannessen, Svein Ivar (Journal article; Peer reviewed, 2016)
      Background: Eslicarbazepine acetate (ESL) is a new anti-epileptic drug (AED) chemically related to oxcarbazepine (OXC) and carbamazepine (CBZ) and is increasingly used in clinical practice. The purpose of the study was to ...

    • The Spectrum of Pyridoxine Dependent Epilepsy in Norway: An Observational Study of Twelve Patients Across the Age Span 

      Jamali, Ahmed (Master thesis, 2022)
      Bakgrunn. Pyridoksinavhengig epilepsi (PDE) er en sjelden, autosomal recessiv neonatal epilepsiencefalopati. Mutasjoner i ALDH7A1-genet er vanligste årsak og gir en forstyrrelse av lysinmetabolismen som blokkerer tilgjengeligheten ...

    • Therapeutic Drug Monitoring of Lacosamide in Norway: Focus on Pharmacokinetic Variability, Efficacy and Tolerability. 

      Svendsen, Torleiv; Brodtkorb, Eylert; Baftiu, Arton; Burns, Margrete Larsen; Johannessen, Svein Ivar; Landmark, Cecilie Johannessen (Journal article; Peer reviewed, 2017)
      Lacosamide (LCM) is a new antiepileptic drug (AED). Experience from therapeutic drug monitoring (TDM) in clinical practice is limited. The purpose of this study is to evaluate the pharmacokinetic variability of LCM in ...