Blar i NTNU Open på forfatter "Bakke, Ingunn"
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Profound gene expression changes in the epithelial monolayer of active ulcerative colitis and Crohn's disease
Sæterstad, Siri; Østvik, Ann Elisabet; Røyset, Elin Synnøve; Bakke, Ingunn; Sandvik, Arne Kristian; Granlund, Atle van Beelen (Peer reviewed; Journal article, 2022)In recent years it has become apparent that the epithelium is highly involved in inflammatory bowel disease (IBD) pathophysiology. The majority of gene expression studies of IBD are generated from heterogeneous biopsies, ... -
Studies of the JAK-inhibitor Tofacitinib on IBD-patient derived intestinal colonoids
Osoble, Nimo Mukhtar Mohamud (Master thesis, 2021)Bakgrunn: Inflammatorisk tarm sykdom (IBD) er en samlebetegnelse for kroniske inflammatoriske sykdommer som rammer tarmen, og inkluderer Crohns sykdom og ulcerøs kolitt. Årsaken til IBD er fortsatt ukjent, men man tror at ... -
Subtle protective roles of clusterin in gastric metaplasia after acute oxyntic atrophy
Vange, Pål; Bruland, Torunn; Munkvold, Bjørn; Røyset, Elin Synnøve; Gleave, Martin E.; Bakke, Ingunn (Journal article; Peer reviewed, 2018) -
The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival
Vange, Pål; Bruland, Torunn; Doseth, Berit; Fossmark, Reidar; Sousa, Mirta; Beisvag, Vidar; Sørdal, Øystein Finset; Qvigstad, Gunnar; Waldum, Helge; Sandvik, Arne Kristian; Bakke, Ingunn (Journal article; Peer reviewed, 2017)The cytoprotective protein clusterin is often dysregulated during tumorigenesis, and in the stomach, upregulation of clusterin marks emergence of the oxyntic atrophy (loss of acid-producing parietal cells)-associated ... -
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium
Gopalakrishnan, Shreya; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Roseth, Ingrid Aass; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Bakke, Ingunn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2022)Major Histocompatibility Complex (MHC)-I and -II genes are upregulated in intestinal epithelial cells (IECs) during active inflammatory bowel diseases (IBD), but little is known about how IBD-relevant pro-inflammatory ... -
Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels
Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen; Damås, Jan Kristian; Østvik, Ann Elisabet; Bruland, Torunn; Sandvik, Arne Kristian (Peer reviewed; Journal article, 2019)Neutrophil gelatinase‐associated lipocalin (NGAL), also known as Lipocalin 2, is an antimicrobial protein, encoded by the gene LCN2, strongly upregulated in inflammatory bowel disease (IBD) and a promising biomarker for ... -
Utforming av læringsutbytte på emnenivå for profesjonsstudiet i medisin
Vie, Gunnhild Åberge; Grimstad, Hilde; Bakke, Ingunn; Wenzel, Hanne Gro; Standal, Rune; Flatås, Kari; Mikkelsen, Maja Elisabeth (Research report, 2021)Sluttrapport fra prosjektgruppen med mandat å utarbeide læringsutbyttebeskrivelser (LUB) på emnenivå for profesjonsstudiet i medisin i forbindelse med innføring av Forskrift om nasjonal retningslinje for medisinsutdanningen. ... -
Verification of gene expression differences on a protein level - An IHC study
Skilbrigt, Ida Maria; Jensen, Sigrid Slettbakk (Master thesis, 2016)Background: Inflammatory bowel disease, a collective term that includes ulcerative colitis and Crohns disease, is an inflammatory disorder that affects the gastrointestinal tract, with symptoms like severe diarrea, pain, ...