Blar i NTNU Open på forfatter "Aachmann, Finn Lillelund"
-
Class IV lasso peptides synergistically induce proliferation of cancer cells and sensitize them to doxorubicin
Madland, Eva; Felipe Guerrero-Garzón, Jaime; Zehl, Martin; Singh, Madhurendra; Rezaei, Shiva; Aachmann, Finn Lillelund; Courtade, Gaston; Urban, Ernst; Rückert, Christian; Busche, Tobias; Kalinowski, Jörn; Cao, Yan-Ru; Jiang, Yi; Jiang, Cheng-lin; Selivanova, Galina; Zotchev, Sergey (Peer reviewed; Journal article, 2020)Heterologous expression of a biosynthesis gene cluster from Amycolatopsis sp. resulted in the discovery of two unique class IV lasso peptides, felipeptins A1 and A2. A mixture of felipeptins stimulated proliferation of ... -
Development of mannuronan C-5 epimerases to perform in vitro tailoring and upgrading of alginates
Stanisci, Annalucia (Doctoral theses at NTNU;2017:325, Doctoral thesis, 2017) -
Differential bacterial capture and transport preferences facilitate co-growth on dietary xylan in the human gut
Leth, Maria Louise; Ejby, Morten; Workman, Christopher; Ewald, David Adrian; Pedersen, Signe Schultz; Sternberg, Claus; Bahl, Martin Iain; Licht, Tine Rask; Aachmann, Finn Lillelund; Westereng, Bjørge; Hachem, Maher Abou (Journal article; Peer reviewed, 2018) -
The effect of linker conformation on performance and stability of a two-domain lytic polysaccharide monooxygenase
Forsberg, Zarah; Stepnov, Anton; Tesei, Giulio; Wang, Yong; Buchinger, Edith; Kristiansen, Sandra; Aachmann, Finn Lillelund; Arleth, Lise; Eijsink, Vincent; Lindorff-Larsen, Kresten; Courtade, Gaston (Journal article; Peer reviewed, 2023)A considerable number of lytic polysaccharide monooxygenases (LPMOs) and other carbohydrate-active enzymes are modular, with catalytic domains being tethered to additional domains, such as carbohydrate-binding modules, by ... -
Effects of novel seaweed ingredients on gluten-free bread quality
Vestå, Ellen Martine (Master thesis, 2022)Etterspørselen etter glutenfritt brød har skutt i været de siste årene på grunn av økt forekomst av cøliaki, samtidig som at mattrenden med å kutte gluten fra kostholdet fordi det er ansett som 'usunt' blir stadig mer ... -
Efficient functionalization of alginate biomaterials
Dalheim, Marianne Øksnes; Vanacker, Julie; Najmi, Maryam A.; Aachmann, Finn Lillelund; Strand, Berit Løkensgard; Christensen, Bjørn E. (Journal article; Peer reviewed, 2016)Peptide coupled alginates obtained by chemical functionalization of alginates are commonly used as scaffold materials for cells in regenerative medicine and tissue engineering. We here present an alternative to the commonly ... -
Efficient Grafting of Cyclodextrin to Alginate and Performance of the Hydrogel for Release of Model Drug
Omtvedt, Line Aanerud; Dalheim, Marianne Øksnes; Nielsen, Thorbjørn T.; Larsen, Kim; Strand, Berit Løkensgard; Aachmann, Finn Lillelund (Journal article; Peer reviewed, 2019)Controlling the rate of release of molecules from a hydrogel is of high interest for various drug delivery systems and medical devices. A strategy to alter the release profiles of soluble and poorly soluble active ingredients ... -
Energy Landscape of Alginate-Epimerase Interactions Assessed by Optical Tweezers and Atomic Force Microscopy
Håti, Armend Gazmeno; Aachmann, Finn Lillelund; Stokke, Bjørn Torger; Skjåk-Bræk, Gudmund; Sletmoen, Marit (Journal article, 2015)Mannuronan C-5 epimerases are a family of enzymes that catalyze epimerization of alginates at the polymer level. This group of enzymes thus enables the tailor-making of various alginate residue sequences to attain various ... -
Enhancement of antimicrobial activity of alginate films with a low amount of carbon nanofibers (0.1% w/w)
Sanmartín-Santos, Isaías; Gandía-Llop, Sofía; Salesa, Beatriz; Martí, Miguel; Aachmann, Finn Lillelund; Serrano-Aroca, Ángel (Journal article; Peer reviewed, 2021) -
Enzyme kinetics of mannuronan C-5 epimerase AlgE4 studied by 13C-NMR and CD spectroscopy
Børve, Marta (Master thesis, 2019)Alginater er en gruppe polysakkarider med et bredt anvendelsesområde. De har ulike fysiske egenskaper, som hovedsakelig bestemmes av sekvensensen til de to monomerne, alfa-D-mannuronat (M) og beta-L-guluronat (G). Sekvensen ... -
Evaluation of S. lividans ΔmatAB as a host for production of lytic polysaccharide monooxygenases
Horten, Kirsti (Master thesis, 2021)Med en stadig økende befolkning, øker også behovet for energi. I dag blir i all hovedsak dette behovet dekket med energi fra fossilt brennstoff. Selv om bruk av ikke-fornybare kilder reduseres, er det fortsatt et behov for ... -
Extraction and characterization of bioactive natural products from brown seaweed Alaria esculenta
Zhang, Shizhe (Master thesis, 2022)Natural products are chemical compounds found in natural sources including terrestrial and marine organisms. In addition to their nutritional values, natural products can also exhibit health benefits such as antipathogenic, ... -
Extraction, Characterization, and Biological Activities of Laminarin and Fucoidan from Laminaria hyperborea
Henriksson, Emilia Linnea (Master thesis, 2019)Fucoidan og laminaran finnes som biprodukter i sidestrømmer som stammer fra alginatproduksjon. Utnyttelse av restråstoff fra tare kan generere produkter av kommersiell verdi, og dermed føre til økonomisk vekst for ... -
Functional Characterisation of Alginate Modifying Enzymes - Enzyme Kinetics of mannuronan C-5 epimerase AlgE4 and Profile of Alginate Lyases PsPL7A-C
Lund-Hanssen, Charlotte (Master thesis, 2021) -
Functional characterization of a lytic polysaccharide monooxygenase from Schizophyllum commune that degrades non-crystalline substrates
Østby, Heidi; Christensen, Idd Andrea; Hennum, Karen; Varnai, Aniko; Buchinger, Edith; Grandal, Siri; Courtade, Gaston; Hegnar, Olav Aaseth; Aachmann, Finn Lillelund; Eijsink, Vincent (Journal article; Peer reviewed, 2023)Lytic polysaccharide monooxygenases (LPMOs) are mono-copper enzymes that use O2 or H2O2 to oxidatively cleave glycosidic bonds. LPMOs are prevalent in nature, and the functional variation among these enzymes is a topic of ... -
Functional characterization of three Azotobacter chroococcum alginate-modifying enzymes related to the Azotobacter vinelandii AlgE mannuronan C-5-epimerase family
Gawin, Agnieszka Maria; Tietze, Lisa; Aarstad, Olav Andreas; Aachmann, Finn Lillelund; Brautaset, Trygve; Ertesvåg, Helga (Peer reviewed; Journal article, 2020)Bacterial alginate initially consists of 1-4-linked beta-D-mannuronic acid residues (M) which can be later epimerized to alpha-L-guluronic acid (G). The family of AlgE mannuronan C-5-epimerases from Azotobacter vinelandii ... -
Genome Mining of Streptomyces sp. YIM 130001 Isolated From Lichen Affords New Thiopeptide Antibiotic
Schneider, Olha; Simic, Nebojsa; Aachmann, Finn Lillelund; Rückert, Christian; Kristiansen, Kåre Andre; Kalinowski, Jörn; Jiang, Yi; Wang, Lisong; Jiang, Cheng-Lin; Lale, Rahmi; Zotchev, Sergey B (Journal article; Peer reviewed, 2018)Streptomyces bacteria are recognized as an important source for antibiotics with broad applications in human medicine and animal health. Here, we report the isolation of a new lichen-associating Streptomyces sp. YIM 130001 ... -
A glycan receptor kinase facilitates intracellular accommodation of arbuscular mycorrhiza and symbiotic rhizobia in the legume Lotus japonicus
Kelly, Simon; Hansen, Simon B.; Rübsam, Henriette; Saake, Pia; Pedersen, Emil B.; Gysel, Kira; Madland, Eva; Wu, Shunliang; Wawra, Stephan; Reid, Dugald; Sullivan, John T.; Blahovska, Zuzana; Vinther, Maria; Muszynski, Artur; Azadi, Parastoo; Thygesen, Mikkel B.; Aachmann, Finn Lillelund; Ronson, Clive W.; Zuccaro, Alga; Andersen, Kasper R.; Radutoiu, Simona; Stougaard, Jens (Peer reviewed; Journal article, 2023)Receptors that distinguish the multitude of microbes surrounding plants in the environment enable dynamic responses to the biotic and abiotic conditions encountered. In this study, we identify and characterise a glycan ... -
Graphene oxide in zinc alginate films: Antibacterial activity, cytotoxicity, zinc release, water sorption/diffusion, wettability and opacity
Frigols, Belen; Marti, Miguel; Salesa, Beatriz; Hernandez-Oliver, Carolina; Aarstad, Olav Andreas; Ulset, Ann-Sissel Teialeret; Sætrom, Gerd Inger; Aachmann, Finn Lillelund; Serrano-Aroca, Angel (Peer reviewed; Journal article, 2019)Alginate is considered an exceptional biomaterial due to its hydrophilicity, biocompatibility, biodegradability, nontoxicity and low-cost in comparison with other biopolymers. We have recently demonstrated that the ... -
Human Chitotriosidase: Catalytic Domain or Carbohydrate Binding Module, Who’s Leading HCHT’s Biological Function
Crasson, Oscar; Courtade, Gaston; Leonard, Raphael R; Aachmann, Finn Lillelund; Legrand, Francois; Parente, Raffaella; Baurain, Denis; Galleni, Moreno; Sørlie, Morten; Vandevenne, Marylene (Journal article; Peer reviewed, 2017)Chitin is an important structural component of numerous fungal pathogens and parasitic nematodes. The human macrophage chitotriosidase (HCHT) is a chitinase that hydrolyses glycosidic bonds between the N-acetyl-D-glucosamine ...