Blar i NTNU Open på tidsskrift "Frontiers in Pharmacology"
Viser treff 1-8 av 8
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Co-prescribing of opioids and benzodiazepines/Z-drugs associated with all-cause mortality—A population-based longitudinal study in primary care with weak opioids most commonly prescribed
(Peer reviewed; Journal article, 2022)Introduction: The risk of mortality associated with the co-prescribing of benzodiazepines and opioids has been explored in a number of papers mainly focusing on strong opioids. The mortality risk associated with the use ... -
Combined targeting of pathways regulating synaptic formation and autophagy attenuates Alzheimer’s disease pathology in mice
(Peer reviewed; Journal article, 2022)All drug trials completed to date have fallen short of meeting the clinical endpoint of significantly slowing cognitive decline in Alzheimer’s disease (AD) patients. In this study, we repurposed two FDA-approved drugs, ... -
Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer
(Peer reviewed; Journal article, 2021)Objective: The aim of the present study was repositioning of ivermectin in treatment of gastric cancer (GC) by computational prediction based on gene expression profiles of human and mouse model of GC and validations with ... -
Drugsniffer: An Open Source Workflow for Virtually Screening Billions of Molecules for Binding Affinity to Protein Targets
(Peer reviewed; Journal article, 2022)The SARS-CoV2 pandemic has highlighted the importance of efficient and effective methods for identification of therapeutic drugs, and in particular has laid bare the need for methods that allow exploration of the full ... -
Editorial: Protection and healing in the digestive system and other tissues: Novel factors, mechanisms, and pharmaceutical targets
(Peer reviewed; Journal article, 2022) -
A Minimal Information Model for Potential Drug-Drug Interactions
(Journal article; Peer reviewed, 2021)espite the significant health impacts of adverse events associated with drug-drug interactions, no standard models exist for managing and sharing evidence describing potential interactions between medications. Minimal ... -
Patient derived colonoids as drug testing platforms-Critical importance of oxygen concentration
(Peer reviewed; Journal article, 2021)Treatment of inflammatory bowel disease (IBD) is challenging, with a series of available drugs each helping only a fraction of patients. Patients may face time-consuming drug trials while the disease is active, thus there ...