Blar i NTNU Open på forfatter "Zhang, Ruyi"
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Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1
Li, Yunlong; Miao, Zhijiang; Li, Pengfei; Zhang, Ruyi; Kainov, Denis; Ma, Zhongren; de Man, Robert A.; Peppelenbosch, Maikel Petrus; Pan, Qiuwei (Journal article; Peer reviewed, 2021)We show that ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic and extrahepatic cells. ... -
Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids
Li, Pengfei; Li, Yunlong; Wang, Yijin; Liu, Jiaye; Lavrijsen, Marla; Li, Yang; Zhang, Ruyi; Verstegen, Monique M.A.; Wang, Yining; Li, Tian-Cheng; Ma, Zhongren; Kainov, Denis; Bruno, Marco J.; de Man, Robert A.; van der Laan, Luc J.W.; Peppelenbosch, Maikel P.; Pan, Qiuwei (Peer reviewed; Journal article, 2022)Hepatotropic viruses naturally have narrow host and tissue tropisms, challenging the development of robust experimental models. The advent of organoid technology provides a unique opportunity for moving the field forward. ...