Blar i NTNU Open på forfatter "Zaph, Colby"
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Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection
Oudhoff, Menno; Antignano, Frann; Chenery, Alistair L; Burrows, Kyle; Redpath, Stephen A; Braam, Mitchell J; Perona-Wright, Georgia; Zaph, Colby (Journal article; Peer reviewed, 2016)The intestine is a common site for a variety of pathogenic infections. Helminth infections continue to be major causes of disease worldwide, and are a significant burden on health care systems. Lysine methyltransferases ... -
Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection
Parmar, Naveen; Burrows, Kyle; Vornewald, Pia M.; Lindholm, Håvard T.; Zwiggelaar, Rosalie T.; Díez-Sánchez, Alberto; Martín-Alonso, Mara; Fosslie, Madeleine; Vallance, Bruce A.; Dahl, John Arne; Zaph, Colby; Oudhoff, Menno J. (Peer reviewed; Journal article, 2021)Infectious and inflammatory diseases in the intestine remain a serious threat for patients world-wide. Reprogramming of the intestinal epithelium towards a protective effector state is important to manage inflammation and ... -
SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling
Oudhoff, Menno; Braam, Mitchell JS; Freeman, Spencer A; Wong, Denise; Rattray, David G; Wang, Jia; Antignano, Frann; Snyder, Kimberly; Refaeli, Ido; Hughes, Michael R; McNagny, Kelly M; Gold, Michael R; Arrowsmith, Cheryl H; Sato, Toshiro; Rossi, Fabio MV; Tatlock, John H; Owen, Dafydd R; Brown, Peter J; Zaph, Colby (Journal article; Peer reviewed, 2016)Intestinal tumorigenesis is a result of mutations in signaling pathways that control cellular proliferation, differentiation, and survival. Mutations in the Wnt/β-catenin pathway are associated with the majority of intestinal ...