Blar i NTNU Open på forfatter "Wolford, Brooke Nichole"

Viser treff 1-3 av 3

    • Evaluation of polygenic scoring methods in five biobanks shows larger variation between biobanks than methods and finds benefits of ensemble learning 

      Monti, Remo; Eick, Lisa; Hudjashov, Georgi; Läll, Kristi; Kanoni, Stavroula; Wolford, Brooke Nichole; wingfield, benjamin; Pain, Oliver; Wharrie, Sophie; Jermy, Bradley; McMahon, Aoife; Hartonen, Tuomo; Heyne, Henrike; Mars, Nina; Lambert, Samuel; Hveem, Kristian; Inouye, Michael; Van Heel, David A.; Mägi, Reedik; Marttinen, Pekka; Ripatti, Samuli; Ganna, Andrea; Lippert, Christoph (Peer reviewed; Journal article, 2024)
      Methods of estimating polygenic scores (PGSs) from genome-wide association studies are increasingly utilized. However, independent method evaluation is lacking, and method comparisons are often limited. Here, we evaluate ...

    • Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification 

      Sutton, Nadia R.; Malhotra, Rajeev; Hilaire, Cynthia S.; Aikawa, Elena; Blumenthal, Roger S.; Gackenbach, Grace; Goyal, Parag; Johnson, Adam; Nigwekar, Sagar U.; Shanahan, Catherine M.; Towler, Dwight A.; Wolford, Brooke Nichole; Chen, Yabing (Peer reviewed; Journal article, 2023)
      Cardiovascular disease is the most common cause of death worldwide, especially beyond the age of 65 years, with the vast majority of morbidity and mortality due to myocardial infarction and stroke. Vascular pathology stems ...

    • Polygenic risk scores associate with blood pressure traits across the lifespan 

      Øvretveit, Karsten; Ingeström, Emma Maria Lovisa; Spitieris, Michail; Tragante, Vinicius; Wade, Kaitlin Hazel; Thomas, Laurent Francois; Wolford, Brooke Nichole; Wisløff, Ulrik; Gudbjartsson, Daníel Fannar; Hólm, Hilma Asbjørn; Stefánsson, Kári; Brumpton, Ben Michael; Hveem, Kristian (Peer reviewed; Journal article, 2023)
      Aims Hypertension is a major modifiable cause of morbidity and mortality that affects over 1 billion people worldwide. Blood pressure (BP) traits have a strong genetic component that can be quantified with polygenic risk ...