Blar i NTNU Open på forfatter "Søgaard, Caroline Danielsen"
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Analysis of DNA Repair Proteins and Chromatin Remodeling Factors Using iPOND
Søgaard, Caroline Danielsen (Master thesis, 2012)Most chemotherapeutic treatments rely on induction of severe DNA damage to kill the cancer cells. However, DNA repair pathways can repair the induced lesions, leading to survival of the tumor cells. Thus, inhibition of DNA ... -
APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer
Søgaard, Caroline Danielsen; Moestue, Siver Andreas; Rye, Morten Beck; Kim, Jana; Nepal, Anala; Liabakk, Nina-Beate; Bachke, Siri; Bathen, Tone Frost; Otterlei, Marit; Hill, Deborah Katherine (Journal article; Peer reviewed, 2018)Docetaxel is the chemotherapeutic choice for metastatic hormone-refractory prostate cancer, however, it only marginally improves the survival rate. The purpose of the present study was to examine if a peptide ... -
Diffusion-weighted MRI for early detection and characterization of prostate cancer in the transgenic adenocarcinoma of the mouse prostate model
Hill, Deborah Katherine; Kim, Eugene; Teruel, Jose Ramon; Jamin, Yann; Widerøe, Marius; Søgaard, Caroline Danielsen; Størkersen, Øystein; Nava Rodriguez, Daniel; Heindl, Andreas; Yuan, Yinyin; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2016)Purpose To improve early diagnosis of prostate cancer to aid clinical decision-making. Diffusion-weighted magnetic resonance imaging (DW-MRI) is sensitive to water diffusion throughout tissues, which correlates with ... -
DNA-basert overvåking av den skandinaviske jervbestanden 2008-2011
Flagstad, Øystein; Tovmo, Mari; Balstad, Torveig; Johansson, Malin; Syslak, Line; Eriksen, Line Birkeland; Spets, Merethe Hagen; Søgaard, Caroline Danielsen; Ellegren, Hans; Brøseth, Henrik (NINI rapport;843, Research report, 2012)Genetiske analyser er de siste årene blitt implementert som et viktig verktøy i rovviltovervåkingen i Skandinavia. I særlig grad har antallet DNA-analyser av ekskrementer økt betydelig. Det siste tiåret er det gjennomført ... -
Increased Anticancer Efficacy of Intravesical Mitomycin C Therapy when combined with a PCNA Targeting Peptide
Gederaas, Odrun Arna; Søgaard, Caroline Danielsen; Viset, Trond; Bachke, Siri; Bruheim, Per; Arum, Carl-Jørgen; Otterlei, Marit (Journal article; Peer reviewed, 2014)Non–muscle-invasive bladder cancers (NMIBCs) are tumors confined to the mucosa or the mucosa/submucosa. An important challenge in treatment of NMIBC is both high recurrence and high progression rates. Consequently, more ... -
Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.
Bjørås, Karine; Sousa, Mirta; Sharma, Animesh; Fonseca, Davi de Miranda; Søgaard, Caroline Danielsen; Bjørås, Magnar; Otterlei, Marit (Journal article; Peer reviewed, 2017)Base lesions in DNA can stall the replication machinery or induce mutations if bypassed. Consequently, lesions must be repaired before replication or in a post-replicative process to maintain genomic stability. Base excision ...