• Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series 

      Yule, Michael S.; Thompson, Joshua; Leesahatsawat, Khachonphat; Sousa, Mariana S.; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta; Dajani, Olav; Fallon, Marie; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; McDonald, James; McGovern, Josh; Roeland, Eric J.; Sayers, Judith; Skipworth, Richard J.E.; Ottestad, Inger; Philips, Iain; Simpson, Melanie Rae; Solheim, Tora S; Vagnildhaug, Ola Magne; McMillan, Donald; Laird, Barry J; Dolan, Ross D. (Journal article; Peer reviewed, 2024)
      Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement ...
    • Hand grip strength in patients with advanced cancer: A prospective study 

      Hadzibegovic, Sara; Porthun, Jan; Lena, Alessia; Weinländer, Pia; Lück, Laura C.; Potthoff, Sophia; Rösnick, Lukas; Fröhlich, Ann-Kathrin; Ramer, Luisa Valentina; Sonntag, Frederike; Wilkenshoff, Ursula; Ahn, Johann; Keller, Ulrich; Bullinger, Lars; Mahabadi, Amir A.; Totzeck, Matthias; Rassaf, Tienush; Von Haehling, Stephan; Coats, Andrew J.S.; Anker, Stefan D.; Roeland, Eric J.; Landmesser, Ulf; Anker, Markus S. (Peer reviewed; Journal article, 2023)
      Background Hand grip strength (HGS) is a widely used functional test for the assessment of strength and functional status in patients with cancer, in particular with cancer cachexia. The aim was to prospectively evaluate ...
    • Patient-reported ability to walk 4 m and to wash: New clinical endpoints and predictors of survival in patients with pre-terminal cancer 

      Lena, Alessia; Anker, Markus S.; Roeland, Eric J.; Porthun, Jan; Schmitz, Sebastian; Hadzibegovic, Sara; Sikorski, Philipp; Wilkenshoff, Ursula; Fröhlich, Ann-Kathrin; Ramer, Luisa Valentina; Rose, Matthias; Eucker, Jan; Rassaf, Tienush; Totzeck, Matthias; Lehmann, Lorenz H.; Von Haehling, Stephan; Coats, Andrew J.S.; Friede, Tim; Butler, Javed; Anker, Stefan D.; Riess, Hanno; Landmesser, Ulf; Bullinger, Lars; Keller, Ulrich; Ahn, Johann (Peer reviewed; Journal article, 2023)
      Background Maintaining the ability to perform self-care is a critical goal in patients with cancer. We assessed whether the patient-reported ability to walk 4 m and wash oneself predict survival in patients with ...
    • Quality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints series 

      Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta; Coats, Andrew J.S.; Dajani, Olav; Dolan, Ross D.; Fallon, Marie T.; Greil, Christine; Grzyb, Alexandra; Kaasa, Stein; Koteng, Lisa Heide; May, Anne M.; McDonald, James; Ottestad, Inger; Philips, Iain; Roeland, Eric J.; Sayers, Judith; Simpson, Melanie Rae; Skipworth, Richard J.E.; Solheim, Tora S; Sousa, Mariana S.; Vagnildhaug, Ola Magne; Laird, Barry J.A. (Journal article; Peer reviewed, 2024)
      The use of patient-reported outcomes (PROMs) of quality of life (QOL) is common in cachexia trials. Patients' self-report on health, functioning, wellbeing, and perceptions of care, represent important measures of efficacy. ...