Blar i NTNU Open på forfatter "Pinto, Sneha M."
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Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation
Pinto, Sneha M.; Kim, Hera; Subbannayya, Yashwanth; Giambelluca, Miriam S.; Bösl, Korbinian; Ryan, Liv; Sharma, Animesh; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2021)Macrophages are sentinels of the innate immune system, and the human monocytic cell line THP-1 is one of the widely used in vitro models to study inflammatory processes and immune responses. Several monocyte-to-macrophage ... -
Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling
Subbannayya, Yashwanth; Pinto, Sneha M.; Bösl, Korbinian; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2019)Dual specificity phosphatases (DUSPs) have a well-known role as regulators of the immune response through the modulation of mitogen-activated protein kinases (MAPKs). Yet the precise interplay between the various members ... -
Molecular alterations in oral cancer using high-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue
Subbannayya, Yashwanth; Pinto, Sneha M. (Journal article, 2021)Loss of cell differentiation is a hallmark for the progression of oral squamous cell carcinoma (OSCC). Archival Formalin-Fixed Paraffin-Embedded (FFPE) tissues constitute a valuable resource for studying the differentiation ... -
Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells
Pinto, Sneha M.; Subbannayya, Yashwanth; Kim, Hera; Hagen, Lars; Górna, Maria W; Nieminen, Anni I.; Bjørås, Magnar; Espevik, Terje; Kaynov, Denis; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2022)COVID-19 pandemic continues to remain a global health concern owing to the emergence of newer variants. Several multi-Omics studies have produced extensive evidence on host-pathogen interactions and potential therapeutic ... -
Temporal quantitative phosphoproteomics profiling of Inter-leukin-33 signaling network reveals unique modulators of monocyte activation
Rex, D. A. B.; Subbannayya, Yashwanth; Modi, Prashant Kumar; Palollathil, Akhina; Gopalakrishnan, Lathika; Bhandary, Yashodhar P.; Prasad, Thottethodi Subrahmanya Keshav; Pinto, Sneha M. (Peer reviewed; Journal article, 2022)Interleukin-33 (IL-33), a member of the IL-1 superfamily cytokines, is an endogenous danger signal and a nuclear-associated cytokine. It is one of the essential mediators of both innate and adaptive immune responses. ... -
UMP-CMP kinase 2 gene expression in macrophages is dependent on the IRF3-IFNAR signaling axis
Kim, Hera; Subbannayya, Yashwanth; Humphries, Fiachra; Skjesol, Astrid; Pinto, Sneha M.; Giambelluca, Miriam; Espevik, Terje; Fitzgerald, Katherine A.; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2021)Toll-like receptors (TLRs) are highly-conserved pattern recognition receptors that mediate innate immune responses to invading pathogens and endogenous danger signals released from damaged and dying cells. Activation of ...