Blar i NTNU Open på forfatter "Kvåle, Svein"
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Acoustic Cluster Therapy (ACT) - pre-clinical proof of principle for local drug delivery and enhanced uptake.
van Wamel, Annemieke; Healey, Andrew; Sontum, Per C.; Kvåle, Svein; Bush, Nigel; Bamber, Jeffrey; Davies, Ruth Catharina de Lange (Journal article; Peer reviewed, 2016)Proof of principle for local drug delivery with Acoustic Cluster Therapy (ACT) was demonstrated in a human prostate adenocarcinoma growing in athymic mice, using near infrared (NIR) dyes as model molecules. A dispersion ... -
Acoustic Cluster Therapy (ACT) enhances the therapeutic efficacy of paclitaxel and Abraxane® for treatment of human prostate adenocarcinoma in mice
van Wamel, Annemieke; Sontum, Per C.; Healey, Andrew; Kvåle, Svein; Bush, Nigel; Bamber, Jeffrey; Davies, Ruth Catharina de Lange (Journal article; Peer reviewed, 2016)Acoustic cluster therapy (ACT) is a novel approach for ultrasound mediated, targeted drug delivery. In the current study, we have investigated ACT in combination with paclitaxel and Abraxane® for treatment of a subcutaneous ... -
Effect of acoustic cluster therapy (ACT®) combined with chemotherapy in a patient-derived xenograft mouse model of pancreatic cancer
Ng, Serina; Healey, Andrew J.; Sontum, Per Christian; Kvåle, Svein; Torp, Sverre Helge; Sulheim, Einar; Von Hoff, Daniel; Han, Haiyoung (Peer reviewed; Journal article, 2022)Pancreatic ductal adenocarcinomas respond poorly to chemotherapy, in part due to the dense tumor stroma that hinders drug delivery. Ultrasound (US) in combination with microbubbles has previously shown promise as a means ... -
Efficient Enhancement of Blood–Brain Barrier Permeability Using Acoustic Cluster Therapy (ACT)
Åslund, Karl Olof Andreas; Snipstad, Sofie; Healey, Andrew J.; Kvåle, Svein; Torp, Sverre Helge; Sontum, Per C.; Davies, Ruth Catharina de Lange; van Wamel, Annemieke (Journal article; Peer reviewed, 2017)The blood-brain barrier (BBB) is a major obstacle in drug delivery for diseases of the brain, and today there is no standardized route to surpass it. One technique to locally and transiently disrupt the BBB, is focused ...