Blar i NTNU Open på forfatter "Carstam, Louise"
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Disulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trial
Jakola, Asgeir S.; Werlenius, Katja; Mudaisi, Munila; Hylin, Sofia; Kinhult, Sara; bartek, Jiri Jr.; Salvesen, Øyvind; Carlsen, Sven Magnus; Strandeus, Michael; Lindskog, Magnus; Lofgren, David; Rydenhaug, Bertil; Carstam, Louise; Gulati, Sasha; Solheim, Ole; Bartek, Jiri; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2018)Background: Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to treat alcoholism since the 1950s. There is now independent preclinical data that supports DSF as an anticancer agent, and ... -
Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients with Recurrent Glioblastoma: A Randomized Clinical Trial
Werlenius, Katja; Kinhult, Sara; Solheim, Tora S; Magelssen, Henriette; Löfgren, David; Mudaisi, Munila; Hylin, Sofia; Bartek, Jiri; Strandéus, Michael; Lindskog, Magnus; Rashid, Havyan Bahroz; Carstam, Louise; Gulati, Sasha; Solheim, Ole Skeidsvoll; Salvesen, Øyvind Olav; Jakola, Asgeir Store (Peer reviewed; Journal article, 2023)Importance Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective To evaluate the efficacy and safety of ... -
Long-term follow up of patients with WHO grade 2 oligodendroglioma
Carstam, Louise; Latini, Francesco; Solheim, Ole Skeidsvoll; Bartek, Jiri; Pedersen, Lars Kjelsberg; Zetterling, Maria; Beniaminov, Stanislav; Sjåvik, Kristin; Ryttlefors, Mats; Jensdottir, Margret; Rydenhag, Bertil; Smits, Anja; Jakola, Asgeir Store (Peer reviewed; Journal article, 2023)Purpose Since the introduction of the molecular definition of oligodendrogliomas based on isocitrate dehydrogenase (IDH)-status and the 1p19q-codeletion, it has become increasingly evident how this glioma entity differs ... -
Psychotropic and anti-epileptic drug use, before and after surgery, among patients with low-grade glioma: a nationwide matched cohort study
Rydén, Isabelle; Thurin, Erik; Carstam, Louise; Smits, Anja; Gulati, Sasha; Henriksson, Roger; Salvesen, Øyvind; Jakola, Asgeir Store (Journal article; Peer reviewed, 2021)Background: Low-grade glioma (LGG) is a relatively rare type of brain tumour. The use of antidepressant, sedative and anti-epileptic drugs can reflect the burden of the disease. While epilepsy is well-described in patients ... -
Socioeconomic factors affect treatment delivery for patients with low grade glioma: a Swedish population-based study
Carstam, Louise; Rydén, Isabelle; Gulati, Sasha; Rydenhag, Bertil; Henriksson, Roger; Salvesen, Øyvind; Smits, Anja; Jakola, Asgeir S (Peer reviewed; Journal article, 2019)Background Despite aspirations to achieve equality in healthcare we know that socioeconomic differences exist and may affect treatment and patient outcome, also in serious diseases such as cancer. We investigated ...