Blar i NTNU Open på forfatter "Blindheim, Fredrik Heen"
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Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates
Singleton, Amanda Holstad; Bergum, Olaug Elisabeth Torheim; Søgaard, Caroline Krogh; Røst, Lisa M.; Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Ræder, Synnøve Brandt; Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge; Bruheim, Per; Otterlei, Marit (Peer reviewed; Journal article, 2023)The past few decades have been plagued by an increasing number of infections caused by antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new antibiotics with novel targets and drug ... -
Chemoenzymatic Synthesis of Synthons as Percursors for Enantiopure Clenbuterol and Other β2-Agonists
Blindheim, Fredrik Heen; Hansen, Mari Bergan; Evjen, Sigvart; Zhu, Wei; Jacobsen, Elisabeth Egholm (Journal article; Peer reviewed, 2018)Clenbuterol is a β2-agonist used in the veterinary treatment of asthma in several countries. The drug is listed on the World Antidoping Agency’s prohibited list due to its effect on increased protein synthesis in the body. ... -
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide
Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Søgaard, Caroline Krogh; Røst, Lise Marie; Singleton, Amanda; Bergum, Olaug Elisabeth Torheim; Bruheim, Per; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2022)Currently, there is a world-wide rise in antibiotic resistance causing burdens to individuals and public healthcare systems. At the same time drug development is lagging behind. Therefore, finding new ways of treating ... -
Synthesis and Evaluation of Azaoxindoles and Pyrrolopyrimidines as Antibacterial Agents
Blindheim, Fredrik Heen (Doctoral theses at NTNU;2022:167, Doctoral thesis, 2022)Antimicrobial resistance is a global problem. Since the end of the golden age of antibiotics in the 1970s, few new antibiotics have been developed and most of these belong to established classes of drugs. As the world’s ... -
Synthesis for Structure-Activity Relationship Study of Bacterial Thymidylate Kinase Inhibitors
Malme, Ane Thoresen (Master thesis, 2020)Abstract will be available on 2023-06-01 -
Synthesis of 4-Amine Substituted Thieno[2,3-d]pyrimidines for Breast Cancer and HER2 Activity Testing
Bye, Haakon Kristvik (Master thesis, 2021)Målet med denne masteroppgaven var å syntetisere 4-aminsubstituerte tienopyrimidiner, og studere deres brystkreftaktivitet og deres aktivitet som human epidermal vekstfaktor reseptor 2, HER2, hemmere. Unormal HER2-signalisering ... -
Synthesis of Enantiopure Precursors for Clenbuterol
Blindheim, Fredrik Heen (Master thesis, 2017)The primary goal of this thesis was to synthesize enantiopure (R)-clenbuterol and its precursors by using enzymes as chiral catalysts. As a secondary goal, the substrate acceptance of ketoreductase 228 (KRED 228) was ... -
Synthesis of Thymidylate Kinase Inhibitor Precursors
Haugen, Thomas Wean (Master thesis, 2019)Multimedikamentresistente bakterier er en av de største helseutfordringene verden står oven- for i dag, noe som gjør forskning og utvikling av ny antibiotika viktigere enn noen sinne. Hemming av et av nøkkelenzymene i ... -
Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents
Blindheim, Fredrik Heen; Olsen, Cecilie Elisabeth; Søgaard, Caroline Krogh; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2021)Imidazopyridinones and 7-azaoxindoles are two classes of heterocyclic compounds with only limited previous use in organic and medicinal chemistry. Various synthetic methods and routes have been evaluated to identify safe ...