Browsing NTNU Open by Author "Vernon, EG"
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Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication
Boeckemeier, L; Kraehenbuehl, R; Keszthelyi, A; Gasasira, MU; Vernon, EG; Beardmore, R; Vågbø, Cathrine Broberg; Chaplin, D; Gollins, S; Krokan, Hans Einar; Lambert, SAE; Paizs, B; Hartsuiker, Edgar (Peer reviewed; Journal article, 2020)The Mre11 nuclease is involved in early responses to DNA damage, often mediated by its role in DNA end processing. MRE11 mutations and aberrant expression are associated with carcinogenesis and cancer treatment outcomes. ...