Browsing NTNU Open by Author "Tiainen, Hanna"
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Adiponectin reduces bone stiffness; verified in a 3D artificial human bone model in vitro
Haugen, Sigrid; He, Jianying; Sundaresan, Alamelu; Stunes, Astrid Kamilla; Aasarød, Kristin Matre; Tiainen, Hanna; Syversen, Unni; Skallerud, Bjørn Helge; Reseland, Janne Elin (Journal article; Peer reviewed, 2018)Primary human osteoblasts and osteoclasts incubated in a rotating coculture system without any scaffolding material, form bone-like tissue that may be used to evaluate effects of various compounds on mechanical strength. ... -
The dose-dependent impact of γ-radiation reinforced with backscatter from titanium on primary human osteoblasts
Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike Jeppesen; Tiainen, Hanna; Ellingsen, Jan Eirik (Peer reviewed; Journal article, 2023)In head and neck cancer patients receiving dental implants prior to radiotherapy, backscatter from titanium increases the radiation dose close to the surface, and may affect the osseointegration. The dose-dependent effects ... -
Early evolution of enamel matrix proteins is reflected by pleiotropy of physiological functions
Spoutil, Frantisek; Aranaz-Novaliches, Goretti; Prochazkova, Michaela; Wald, Tomas; Novosadova, Vendula; Kasparek, Petr; Osicka, Radim; Reseland, Janne Elin; Lyngstadaas, Ståle Petter; Tiainen, Hanna; Bousova, Kristyna; Vondrasek, Jiri; Sedlacek, Radislav; Prochazka, Jan (Peer reviewed; Journal article, 2023)Highly specialized enamel matrix proteins (EMPs) are predominantly expressed in odontogenic tissues and diverged from common ancestral gene. They are crucial for the maturation of enamel and its extreme complexity in ... -
Osteocyte-Like Cells Differentiated From Primary Osteoblasts in an Artificial Human Bone Tissue Model
Munir, Arooj; Reseland, Janne Elin; Tiainen, Hanna; Haugen, Håvard Jostein; Sikorski, Pawel; Christiansen, Emil; Reinholt, Finn P.; Syversen, Unni; Solberg, Lene Bergendal (Peer reviewed; Journal article, 2023)In vitro models of primary human osteocytes embedded in natural mineralized matrix without artificial scaffolds are lacking. We have established cell culture conditions that favored the natural 3D orientation of the bone ... -
Stabilisation of amorphous calcium phosphate in polyethylene glycol hydrogels
Schweikle, Manuel; Bjørnøy, Sindre Hove; Van Helvoort, Antonius; Haugen, Håvard Jostein; Sikorski, Pawel; Tiainen, Hanna (Journal article; Peer reviewed, 2019)Acellular polymer-calcium phosphate composites are promising bone graft materials. Hydrogels are suitable for providing a temporary matrix, while calcium phosphate minerals serve as ion depots for calcium and phosphate ...