Browsing NTNU Open by Author "Sekurova, Olga"
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Genomics of Sponge-Associated Streptomyces spp. Closely Related to Streptomyces albus J1074: Insights into Marine Adaptation and Secondary Metabolite Biosynthesis Potential
Ian, Elena; Malko, Dmitry B.; Sekurova, Olga; Bredholt, Harald; Rückert, Christian; Borisova, Marina E.; Albersmeier, Andreas; Kalinowski, Jörn; Gelfand, Mikhail S.; Zotchev, Sergey (Journal article; Peer reviewed, 2014)A total of 74 actinomycete isolates were cultivated from two marine sponges, Geodia barretti and Phakellia ventilabrum collected at the same spot at the bottom of the Trondheim fjord (Norway). Phylogenetic analyses of ... -
Mining, Analysis and Targeted Activation of Secondary Metabolite Gene Clusters in Streptomyces bambergiensis
Joelsson, Jon Petur (Master thesis, 2015)The discovery of new antibiotics is one of the most urgent tasks facing scientists today. The escalating rate of resistant microbes creates a constant need for new or improved drugs. With the recent progress in genome ... -
Re-wiring of antibiotic biosynthesis regulation in Streptomyces venezuelae for inducible heterologous production of secondary metabolites
Pawlikowska, Joanna (Master thesis, 2014)Streptomyces venezuelae ATCC10712 which is an object of research investigation during this master thesis belongs to Actinomycetales which are widely recognized as a producer of antibiotics. Secondary metabolites synthesis ... -
Studies on the biosynthesis of antibiotic nystatin with emphasis on regulation
Sekurova, Olga (Doktoravhandlinger ved NTNU, 1503-8181; 2013:63, Doctoral thesis, 2013)Nystatin is an antifungal polyene macrolide antibiotic produced by Streptomyces noursei, first described in 1950 (Hazen and Brown, 1950). Nystatin is currently being used for treatment of superficial fungal infections, and ... -
Synthetic biology for drug discovery: construction of biosensors for detection of endogenously produced bacterial secondary metabolites
Sandbakken, Ingrid Schafroth (Master thesis, 2013)Streptomycete bacteria are a great source of natural bioactive secondary metabolites, some of which are being used as antibiotics and anticancer drugs. Many streptomycetes have the genomic potential for producing 20-30 ...