Browsing NTNU Open by Author "Ottestad, William Arne"
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Biphasic release of the alarmin high mobility group box 1 protein early after trauma predicts poor clinical outcome
Ottestad, William Arne; Rognes, Ingrid Nygren; Pischke, Søren; Mollnes, Tom Eirik; Andersson, Ulf; Eken, Torsten (Journal article; Peer reviewed, 2019)Objectives: The causal role of the prototype alarmin high mobility group box 1 protein in systemic inflammation and remote organ injury after trauma and shock is established in animal models but not in humans. Our aim ... -
Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study
Sundnes, Olav; Ottestad, William Arne; Schjalm, Camilla; Lundbäck, Peter; La Cour Poulsen, Lars; Mollnes, Tom Eirik; Haraldsen, Guttorm; Eken, Torsten (Journal article; Peer reviewed, 2021)Background Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, ...