Browsing NTNU Open by Author "Olsen, Ann-Karin Hardie"
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Effects of environmental exposure: Interplay between helix-distorting and oxidative DNA lesions and their repair
Lakså, Solveig Margrethe B. (Master thesis, 2012)DNA lesions are introduced in all living organisms every day, both via endogenous processes and by exposure to an array of DNA damaging agents. DNA lesions require repair for the sustenance of life. Base excision repair ... -
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
Hildrestrand, Gunn Annette; Rolseth, Veslemøy; Kunath, Nicolas; Suganthan, Rajikala; Jensen, Vidar; Bugaj, Anna Maria; Fernandez Berrocal, Marion Silvana; SIkko, Sunniva Bøe; Vetlesen, Susanne; Kusnierczyk, Anna; Olsen, Ann-Karin Hardie; Gutzkow, Kristine Bjerve; Rowe, Alexander D.; Wang, Wei; Moldestad, Olve; Syrstad, Monika; Slupphaug, Geir; Eide, Lars; Klungland, Arne; Sætrom, Pål; Luna, Luisa; Ye, Jing; Scheffler, Katja; Bjørås, Magnar (Peer reviewed; Journal article, 2021)Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 ...