Browsing NTNU Open by Author "Malhotra, Rajeev"
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Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization
Zheng, Jie; Wheeler, Eleanor; Pietzner, Maik; Andlauer, Till F.M.; Yau, Michelle S.; Hartley, April E.; Brumpton, Ben Michael; Rasheed, Humaira; Kemp, John P.; Frysz, Monika; Robinson, Jamie; Reppe, Sjur; Prijatelj, Vid; Gautvik, Kaare M; Falk, Louise; Maerz, Winfried; Gergei, Ingrid; Peyser, Patricia A; Kavousi, Maryam; de Vries, Paul S.; Miller, Clint L.; Bos, Maxime; Van Der Laan, Sander W.; Malhotra, Rajeev; Herrmann, Markus; Scharnagl, Hubert; Kleber, Marcus; Dedoussis, George; Zeggini, Eleftheria; Nethander, Maria; Ohlsson, Claes; Lorentzon, Mattias; Wareham, Nick; Langenberg, Claudia; Holmes, Michael V.; Smith, George Davey; Tobias, Jonathan H. (Peer reviewed; Journal article, 2023)Objective In this study, we aimed to establish the causal effects of lowering sclerostin, target of the antiosteoporosis drug romosozumab, on atherosclerosis and its risk factors. Methods A genome-wide association ... -
Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification
Sutton, Nadia R.; Malhotra, Rajeev; Hilaire, Cynthia S.; Aikawa, Elena; Blumenthal, Roger S.; Gackenbach, Grace; Goyal, Parag; Johnson, Adam; Nigwekar, Sagar U.; Shanahan, Catherine M.; Towler, Dwight A.; Wolford, Brooke Nichole; Chen, Yabing (Peer reviewed; Journal article, 2023)Cardiovascular disease is the most common cause of death worldwide, especially beyond the age of 65 years, with the vast majority of morbidity and mortality due to myocardial infarction and stroke. Vascular pathology stems ...