Browsing NTNU Open by Author "Lyle, Robert"
Now showing items 1-3 of 3
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Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells
Tekpli, Xavier; Urbanucci, Alfonso; Hashim, Adnan; Vågbø, Cathrine Broberg; Lyle, Robert; Kringen, Marianne K.; Staff, Anne Cathrine; Dybedal, Ingunn; Mills, Ian Geoffrey; Klungland, Arne; Staerk, Judith (Journal article; Peer reviewed, 2016)Background Hematopoietic stem cell renewal and differentiation are regulated through epigenetic processes. The conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5hmC) by ten-eleven-translocation enzymes provides ... -
Modeling dependency structures in 450k DNA methylation data
Nustad, Haakon Egdetveit; Steinsland, Ingelin; Ollikainen, Miina; Cazaly, Emma; Kaprio, Jaakko; Benjamini, Yuval; Gervin, Kristina; Lyle, Robert (Peer reviewed; Journal article, 2022)Motivation DNA methylation has been shown to be spatially dependent across chromosomes. Previous studies have focused on the influence of genomic context on the dependency structure, while not considering differences ... -
Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication
Diaz, Javier Pena; Hegre, Siv Anita; Anderssen, Endre; Aas, Per Arne; Mjelle, Robin; Gilfillan, Gregor Duncan; Lyle, Robert; Drabløs, Finn; Krokan, Hans Einar; Sætrom, Pål (Journal article; Peer reviewed, 2013)