Browsing NTNU Open by Author "Li, Pengfei"
Now showing items 1-4 of 4
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Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response
Wang, Yining; Li, Pengfei; Xu, Lei; de Vries, Annemarie C.; Rottier, Robbert J.; Wang, Wenshi; Crombag, Marie-Rose B.S.; Peppelenbosch, Maikel P.; Kaynov, Denis; Pan, Qiuwei (Peer reviewed; Journal article, 2023)Severe infections with coronaviruses are often accompanied with hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral ... -
Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1
Li, Yunlong; Miao, Zhijiang; Li, Pengfei; Zhang, Ruyi; Kainov, Denis; Ma, Zhongren; de Man, Robert A.; Peppelenbosch, Maikel Petrus; Pan, Qiuwei (Journal article; Peer reviewed, 2021)We show that ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic and extrahepatic cells. ... -
Pharmacokinetics of Perfluorobutane after Intra-venous Bolus Injection of Sonazoid in Healthy Chinese Volunteers.
Li, Pengfei; Hoppmann, Susan; Du, Ping; Li, Huiling; Evans, Paul; Moestue, Siver Andreas; Yu, Weiyue; Dong, Fang; Liu, Hongchuan; Liu, Lihong (Journal article; Peer reviewed, 2017)Sonazoid is an ultrasound contrast agent based on microbubbles (MB) containing perfluorobutane (PFB) gas. Sonazoid is approved in Japan, Korea and Norway for contrast-enhanced ultrasonography of focal liver lesions and ... -
Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids
Li, Pengfei; Li, Yunlong; Wang, Yijin; Liu, Jiaye; Lavrijsen, Marla; Li, Yang; Zhang, Ruyi; Verstegen, Monique M.A.; Wang, Yining; Li, Tian-Cheng; Ma, Zhongren; Kainov, Denis; Bruno, Marco J.; de Man, Robert A.; van der Laan, Luc J.W.; Peppelenbosch, Maikel P.; Pan, Qiuwei (Peer reviewed; Journal article, 2022)Hepatotropic viruses naturally have narrow host and tissue tropisms, challenging the development of robust experimental models. The advent of organoid technology provides a unique opportunity for moving the field forward. ...