Browsing NTNU Open by Author "Johansson, Ida"
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A Dual Role of Autophagy in Disease Prevention and Drug Resistance
Johansson, Ida (Doctoral thesis at NTNU;2015:310, Doctoral thesis, 2015)Aging is associated with various diseases, such as neurodegenerative diseases. However, individual risk of developing these age-related diseases clearly varies due to differences in both genetic and environmental factors. ... -
Exploring drug resistance mechanisms in Multiple Myeloma - Focusing on the role of immunoglobulin kappa light chain and protein secretion
Stortjønnli, Kamilla Isaksen (Master thesis, 2019)Multiple myeloma (MM) is a type of cancer arising in the bone marrow affecting the immunoglobulin (Ig) producing plasma cells. This causes an uncontrolled proliferation of a single plasma cell clone and an overproduction ... -
Exploring the effect of arginine starvation on autophagy and type I IFN response in cancer cells
Rylander, Eva Felicia (Master thesis, 2021)Female breast cancer is now estimated to be the most diagnosed cancer, accounting for 11.7% of all cancer cases worldwide. Tumors are heterogenous tissues consisting of various types of cells together creating the tumor ... -
Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells
Starheim, Kristian Kobbenes; Holien, Toril; Misund, Kristine; Johansson, Ida; Baranowska, Katarzyna Anna; Sponaas, Anne Marit; Hella, Hanne; Buene, Glenn; Waage, Anders; Sundan, Anders; Bjørkøy, Geir (Journal article; Peer reviewed, 2016)Multiple myeloma (myeloma in short) is an incurable cancer of antibody-producing plasma cells that comprise 13% of all hematological malignancies. The proteasome inhibitor bortezomib has improved treatment significantly, ... -
Kromatin immunopresipitering for studier av interferon regulerte faktorer
Johansson, Ida (Master thesis, 2009) -
N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2
Mildenberger, Jennifer; Johansson, Ida; Sergin, Ismail; Kjøbli, Eli; Damås, Jan Kristian; Razani, Babak; Flo, Trude Helen; Bjørkøy, Geir (Journal article; Peer reviewed, 2017)Inflammation is crucial in the defense against infections but must be tightly controlled to limit detrimental hyperactivation. Our diet influences inflammatory processes and omega-3 polyunsaturated fatty acids (n-3 PUFAs) ... -
Opposite and dynamic regulation of the interferon response in metastatic and non-metastatic breast cancer
Lamsal, Apsana; Andersen, Sonja Benedikte; Johansson, Ida; Vietri, Marina; Bokil, Ansooya Avinash; Kurganovs, Natalie Jayne; Rylander, Felicia; Bjørkøy, Geir; Pettersen, Kristine; Giambelluca, Miriam Soledad (Peer reviewed; Journal article, 2023)Background To our current understanding, solid tumors depend on suppressed local immune reactions, often elicited by the interaction between tumor cells and tumor microenvironment (TME) components. Despite an improved ... -
The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells
Johansson, Ida; Monsen, Vivi Anita Talstad; Pettersen, Kristine; Mildenberger, Jennifer; Misund, Kristine; Kaarniranta, Kai; Schønberg, Svanhild Margrethe Arentz; Bjørkøy, Geir (Journal article; Peer reviewed, 2015)Accumulation and aggregation of misfolded proteins is a hallmark of several diseases collectively known as proteinopathies. Autophagy has a cytoprotective role in diseases associated with protein aggregates. Age-related ...