Browsing NTNU Open by Author "Ix, Joachim H."
Now showing items 1-7 of 7
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Clinical phenotypes and long-term prognosis in white patients with biopsy-verified hypertensive nephrosclerosis
Øvrehus, Marius Altern; Oldereid, Tine Simensen; Dadfar, Aydin; Bjørneklett, Rune; Aasarød, Knut; Fogo, Agnes B.; Ix, Joachim H.; Hallan, Stein (Peer reviewed; Journal article, 2020)Introduction Hypertensive nephrosclerosis is considered the second most common cause of end-stage renal disease (ESRD), but it is still an insufficiently studied and controversial disease entity. More information on the ... -
Clinical Risk Factors For Kidney Tubule Biomarker Abnormalities Among Hypertensive Adults With Reduced eGFR in the SPRINT Trial
Ikeme, Jesse C.; Katz, Ronit; Muiru, Anthony N.; Estrella, Michelle M.; Scherzer, Rebecca; Garimella, Pranav S.; Hallan, Stein; Peralta, Carmen A.; Ix, Joachim H.; Shlipak, Michael G. (Peer reviewed; Journal article, 2022)BACKGROUND Urine biomarkers of kidney tubule health may distinguish aspects of kidney damage that cannot be captured by current glomerular measures. Associations of clinical risk factors with specific kidney tubule ... -
Estimated Kidney Tubular Secretion and Kidney, Cardiovascular, and Mortality Outcomes in CKD: The Systolic Blood Pressure Intervention Trial
Ascher, Simon B.; Shlipak, Michael G.; Katz, Ronit; Bullen, Alexander L.; Scherzer, Rebecca; Hallan, Stein; Cheung, Alfred K.; Raphael, Kalani L.; Estrella, Michelle M.; Jotwani, Vasantha K.; Seegmiller, Jesse C.; Ix, Joachim H.; Garimella, Pranav S. (Peer reviewed; Journal article, 2022)Rational & Objective Many drugs, metabolites, and toxins are cleared by the kidneys via tubular secretion. Whether novel endogenous measures of tubular secretion provide information about kidney, cardiovascular, and ... -
Hypertensive nephrosclerosis: wider kidney biopsy indications may be needed to improve diagnostics
Hallan, Stein; Øvrehus, Marius Altern; Bjørneklett, Rune; Aasarød, Knut Ivar; Fogo, Agnes B.; Ix, Joachim H. (Peer reviewed; Journal article, 2020)Background. Hypertensive nephrosclerosis is the presumed underlying cause in many end-stage kidney disease (ESKD) patients, but the diagnosis is disputed and based on clinical criteria with low diagnostic accuracy. Objective. ... -
Markers of Kidney Tubular Secretion and Risk of Adverse Events in SPRINT Participants with CKD
Bullen, Alexander L.; Ascher, Simon B.; Scherzer, Rebecca; Garimella, Pranav S.; Katz, Ronit; Hallan, Stein; Cheung, Alfred K.; Raphael, Kalani L.; Estrella, Michelle M.; Jotwani, Vasantha K.; Malhotra, Rakesh; Seegmiller, Jesse C.; Shlipak, Michael G.; Ix, Joachim H. (Peer reviewed; Journal article, 2022)Significance Statement SPRINT demonstrated in individuals with hypertension and high cardiovascular disease (CVD) risk that intensive BP lowering was associated with decreased risk of CVD events and all-cause mortality. ... -
Physicians’ Recognition and Management of Kidney Disease: A Randomized Vignette Study Evaluating the Impact of the KDIGO 2012 CKD Classification System
Hallan, Stein; Rifkin, Dena E; potok, olivia; Langlo, Knut Asbjørn Rise; Dekker, Friedo W.; Ix, Joachim H. (Peer reviewed; Journal article, 2020)Rationale & Objective The Kidney Disease Outcome Quality Initiative (KDOQI) and Kidney Disease: Improving Global Outcomes (KDIGO) chronic kidney disease (CKD) classification systems published in 2002 and 2012, respectively, ... -
Structured Moderate Exercise and Biomarkers of Kidney Health in Sedentary Older Adults: The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial
Sheshadri, Anoop; Lai, Mason; Hsu, Fang-Chi; Bauer, Scott R.; Chen, Shyh-Huei; Tse, Warren; Jotwani, Vasantha; Tranah, Gregory J.; Lai, Jennifer C.; Hallan, Stein Ivar; Fielding, Roger A.; Liu, Christine; Ix, Joachim H.; Coca, Steven G.; Shlipak, Michael G. (Peer reviewed; Journal article, 2023)Rationale & Objective In the Lifestyle Interventions and Independence for Elders (LIFE) trial, a structured exercise intervention slowed kidney function decline in sedentary older adults. Biomarkers of kidney health could ...