Browsing NTNU Open by Author "Haram, Karin Margrete"
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A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery
Lage Fernandez, Jessica; Årbogen, Sara Beate Stjern; Sadeghinia, Mohammadjavad; Haram, Karin Margrete; Snipstad, Sofie; Torp, Sverre Helge; Einen, Caroline; Mühlenpfordt, Melina; Maardalen, Matilde; Vikedal, Krister; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy, mainly due to its resistance to chemotherapy and its complex tumour microenvironment characterised by stromal desmoplasia. There is a need for new ... -
Treatment of Liver Metastases With Focused Ultrasound and Microbubbles in Patients With Colorectal Cancer Receiving Chemotherapy
Haram, Karin Margrete; Hansen, Rune; Bouget, David Nicolas Jean-Marie; Myhre, Ola Finneng; Davies, Catharina de Lange; Hofsli, Eva (Journal article; Peer reviewed, 2023)Objective: Pre-clinical trials have obtained promising results that focused ultrasound (FUS) combined with microbubbles (MBs) increases tumor uptake and the therapeutic effect of drugs. The aims of the study described here ... -
Ultrasound and Microbubbles Increase the Uptake of Platinum in Murine Orthotopic Pancreatic Tumors
Haram, Karin Margrete; Snipstad, Sofie; Berg, Sigrid; Mjønes, Patricia; Rønne, Elin; Lage Fernandez, Jessica; Mühlenpfordt, Melina; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Objective Currently available cytotoxic treatments have limited effect on pancreatic ductal adenocarcinoma (PDAC) because desmoplastic stroma limits drug delivery. Efforts have been made to overcome these barriers by drug ...